Sabril 500 mg

Sabril 500 mg Image

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Sabril Facts

Sabril is manufactured by Patheon for distribution by Lundbeck, Inc.

In clinical trials for Sabril, 3,139 adult patients and 999 pediatric patients were treated with the drug.

Controlled clinical trials of Sabril involving infants were brief, and tested just a few patients.

Sabril obtained its first approval from the FDA on August 21, 2009.

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Best Value On Brand Sabril 500 mg
Price: $1.76 per tab!
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Sabril 500 mg Prescription Required
100 tabs for $176.14 ($1.76 per tab)
Sabril from online pharmacy: Canada
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Sabril General Information

Sabril is the brand name for the antiepileptic drug vigabatrin. Primarily, Sabril is used to treat infantile spasms, as well as several types of seizures, including those seizures which have been resistant to other drug therapies.

How does Sabril work & What does it do?

Seizures are due to an overactivity of brain cells, and the corresponding convulsions or spasms are the physical manifestations of this brain activity. The neurotransmitter GABA is involved in inhibitory activity in the brain, and many antiepileptic drugs directly target GABA receptors to stop seizure activity. Instead of directly affecting GABA receptors, Sabril prevents the breakdown of naturally occurring GABA in the brain, allowing GABA to perform its normal duties of helping to stop the progression of the seizure. Sabril is often used in conjunction with other antiepilepsy medications, or used when traditional antiepileptic drugs have not proven effective in a patient. In adults, Sabril would be used for this purpose in cases of complex partial seizures, treatment resistant epilepsy, tonic-clonic seizures, and partial seizures. Oftentimes, Sabril is used to treat infantile spasms as a result of West syndrome, since Sabril carries less risk of physical harm and dependency seen by other antiepileptic drugs, such as benzodiazepines. Additionally, there have preliminary studies using Sabril to help prevent former cocaine and methamphetamine users from relapsing, and initial results from these studies seem promising. Other future uses of Sabril could include helping to treat panic disorder and certain physical tremors of Huntington's disease.

When/How is Sabril taken/used/applied?

Sabril is available in both powder and tablet form. Dosages vary based on the type of patient and their disorder. With the powder form, a given dosage of the powder is generally dissolved in 10 mL of water and swallowed, but can also be put on top of a soft food such as pudding or applesauce and eaten. The powder form for adults with epilepsy generally starts with an oral dosage of 1000 mg a day, taken once a day, building up to, but not exceeding 4000 mg a day. For children with epilepsy, the powder form is taken twice a day, and dosage depends on the child's weight; for example, 40 mg/kg is a starting dose for a child, and should not exceed 100 mg/kg per day total. For infantile spasms, dosages range from 50-100 mg/kg split into two smaller doses, administered orally twice a day. For the tablet form of Sabril, dosages are the same for adults and children, along with the dosage schedule, but tablets should not be used for infantile spasms due to the risk of choking hazards.

Side Effects

Central nervous system side effects are the most prevalent for users of Sabril, with sleepiness, headaches, insomnia, dizziness, nervousness, and depression being the most common. However, it must be noted that most of these side effects occur in less than 5% of patients. The next most common group of side effects involve somatic discomfort, such as fatigue, weight gain, or body pain. Gastrointestinal complaints have also been reported in a small amount of patients, including nausea, vomiting, intestinal or abdominal pain, and constipation. Rare side effects such as amnesia and yellow-blue color blindness have occasionally been reported, and would require immediate medical attention.

Other Brand Names for Sabril:

Sabril (vigabatrin) is currently only available as a brand name medication in the United States, so there are no other generic versions or brand names available.

Safety Information:

Patients with only myclonic-type seizures should avoid Sabril, since a paradoxical effect may be seen where seizure frequency is actually increased. Caution must be used when a patient taking Sabril is also prescribed drugs such as carbamazepine or phenytoin, since the action and liver clearance of these drugs may be affected by Sabril. Patients with kidney damage may want to avoid taking Sabril, since Sabril may not be cleared from the body as quickly, thus increasing the chance of side effects. Patients with a history of mental illness should avoid taking Sabril, as the propensity for a recurring episode of mental illness could occur after administration of the medication. Patients who are pregnant or nursing should avoid Sabril, since studies have not been performed demonstrating that Sabril needed by a mother would be safe for an infant who lacks epilepsy symptoms. Finally, cessation of Sabril should be done under a doctors supervision, with a gradual taper, since abruptly stopping Sabril treatment can le

ad to dangerous rebound seizures.


  • Powder - 500 mg inside of a plastic packet
  • Tablet - 500 mg

Visual Description:

Powder - 500 mg inside of a white plastic packet which may be torn. The packet contains, on one side, red writing which says "Sabril 500 mg powder for oral solution, vigabatrin," with the "Aventis" logo beneath the script. The reverse side of the packet contains a pictorial description of how to tear open the packet and pour the contents into a glass of water. Tablet - 500 mg - Oblong, tan, scored tablet with "Sabrin" written on the unscored side.