Invirase 200 mg

 
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Best Value On Brand Invirase 200 mg
Price: $2.52 per capsule!
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Invirase 200 mg Prescription Required
270 capsules for $680.82 ($2.52 per capsule)
Invirase from online pharmacy: South Africa
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Enjoy the convenience and discreet packaging when you order Invirase 200 mg from The Drug Company. Treat with confidence, as per your doctor's advice, and save money by having your medications mailed to your home at a discount. If you require Invirase 200 mg for your health and well being, there are several ways to save money and still order your prescription. One method is to order from a Canadian pharmacy. Another is to order a generic substitute. Speak with your doctor and view our selection of rx and otc items for sale at our online store. You also always have the option of calling toll free 1-888-254-3038, or using our online chat tool.

About Invirase

What Invirase is used for

In adults and adolescents over the age of 16 years, INVIRASE (saquinavir mesylate) in combination with Norvir (ritonavir) and other anti-HIV drugs is used for the treatment of HIV, the virus that causes AIDS. INVIRASE belongs to a class of drugs called protease (pronounced PRO-tee-ase) inhibitors.

What Invirase does

As you may know, the immune system is the body's main defence against infection. The immune system includes special cells that recognize and destroy harmful bacteria and viruses. As HIV grows, it destroys these cells—leaving fewer immune cells, and a greater risk of infection. INVIRASE works by fighting HIV as it grows inside cells by blocking an enzyme (protease) that HIV needs to reproduce.

INVIRASE is not a cure for HIV and/or AIDS, though it may help to slow the progression of HIV disease in your body. While taking INVIRASE however, you may continue to acquire illnesses associated with advanced HIV infection (i.e. opportunistic infections).

It is important to remember that there is NO evidence which suggests that INVIRASE can prevent the transmission of HIV. INVIRASE is NOT therefore a substitute for other measures which have been proven effective in this regard. To avoid transmission of HIV, you should not donate blood, share needles, or engage in unprotected sexual activity (i.e. without a condom).

When Invirase should not be used

  • INVIRASE should not be used unless taken with Norvir (ritonavir);

  • INVIRASE should not be used if you are sensitive to saquinavir or to any other component contained in the capsule or tablet (see What the important nonmedicinal ingredients are:);

  • INVIRASE/ritonavir should not be used if you have severe liver problems;

  • INVIRASE/ritonavir should not be used if you are taking or plan on taking any of the following medications:

Drug Class Drugs within Class Not to be Taken with INVIRASE/Norvir (ritonavir)
Antiarrhythmics Cordarone (amiodarone), Tambocor (flecainide), Rythmol (propafenone), bepridil, quinidine
Antihistamines Seldane (terfenadine)a, Hismanal (astemizole)a
Antimigraines Ergot medications (eg, Ergodryl and Cafergot)
Antimycobacterial Agents Rifampin
GI Motility Agents Prepulsid (cisapride)a
Sedative/Hypnotics Versed (midazolam), Halcion (triazolam)
Neuroleptics Pimozide
a. No longer marketed in Canada.

INVIRASE causes increased blood levels of these medicines. This can lead to serious or life-threatening reactions such as irregular heartbeat or prolonged sedation. Rifampin, in combination with INVIRASE and ritonavir, may also cause severe liver problems.

Taking INVIRASE with St. John’s Wort (hypericum perforatum), a herbal product sold as a dietary supplement, or products containing St. John’s Wort is not recommended. Taking St. John’s Wort may decrease INVIRASE levels and lead to increased viral load and possible resistance to INVIRASE or cross-resistance to other antiretroviral drugs.

Garlic capsules should not be used while taking saquinavir without ritonavir due to the risk of decreased saquinavir in the blood. No data are available for the coadministration of INVIRASE and Norvir with garlic capsules.

Your doctor may want to change your medicine if you are taking Mycobutin (rifabutin) or Sustiva (efavirenz) since these drugs substantially reduce the level of INVIRASE in the blood.

What the medicinal ingredient is

The medicinal ingredient found in both INVIRASE capsules and INVIRASE tablets is saquinavir mesylate.

What the important nonmedicinal ingredients for Invirase are

INVIRASE capsules contain the following nonmedicinal ingredients: lactose, magnesium stearate, microcrystalline cellulose, povidone, sodium starch glycolate, and talc. The capsule shells are made from gelatin, indigotine, iron oxide, and titanium dioxide.

INVIRASE tablets contain the following nonmedicinal ingredients: croscarmellose sodium, lactose, magnesium stearate, microcrystalline cellulose, and povidone K30. Each film coat contains hypromellose, iron oxide red, iron oxide yellow, talc, titanium dioxide, and triacetin.

If you know you have an allergy or have had a serious reaction to any of the ingredients, such as lactose, you must not use INVIRASE.

What dosage forms Invirase comes in

INVIRASE is available as a 200 mg hard gelatin capsule and as a 500 mg film coated tablet.


Warnings and Precautions

Serious Warnings and Precautions

  • INVIRASE should not be used unless it is taken with Norvir (ritonavir).

  • Serious or life-threatening interactions may occur when using INVIRASE in combination with other medications (see Interactions with This Medication: and About This Medication: When it should not be used:).

  • INVIRASE/ritonavir should not be used if you have severe liver problems.

Before you use INVIRASE talk to your doctor or pharmacist if:

  • you have ever had a bad reaction to saquinavir (INVIRASE or FORTOVASE), any component of the capsules or tablet, or any other brand of protease inhibitor;

  • you have lactose intolerance. This product contains lactose;

  • you have a problem with your liver or kidneys;

  • you have hemophilia;

  • you have diabetes. Diabetes may be worsened by medicines in the same class as INVIRASE and your dosage of diabetes medicine may have to be adjusted;

  • you have been told that you have high blood cholesterol or triglyceride levels;

  • you have any other illnesses besides HIV infection;

  • you are taking or plan on taking ANY other drugs (including herbal preparations, especially St. John’s Wort and garlic, drugs you purchase without prescriptions, and those not prescribed by your doctor);

    or

  • you are pregnant, plan on becoming pregnant, or are breast-feeding a child.

This information will help you and your physician decide if the potential benefits of treating your condition with INVIRASE outweigh the possible risks.

No studies have been conducted on the ability to drive or operate machinery while taking INVIRASE. There is no evidence that INVIRASE may alter your ability to drive and use machines.


Interactions with Invirase

There are many medications that may interact with INVIRASE. If you are taking or plan on taking any other medications (prescription or non-prescription, including herbal preparations), tell your doctor or pharmacist.

Special attention is warranted when using INVIRASE with HMG-CoA reductase inhibitors (cholesterol lowering medications), nasal steroids such as Flonase (fluticasone propionate) and PDE5 inhibitors (medicines used to treat erectile dysfunction).

Caution should be taken when taking INVIRASE with digoxin. Your doctor may want to monitor the levels of digoxin in your blood and the dose of digoxin may need to be decreased.

Special attention is also warranted when taking drugs such as: antidepressants, anticoagulants, anticonvulsants, and antiarrhythmics. In any of these instances your doctor may need to change your dose and monitor you more closely.

Drugs that should not be taken with INVIRASE are discussed in the section above entitled “About This Medication: When it should not be used:”.


Proper Use of Invirase

Usual Dose—Adults and adolescents over 16 years of age

Your doctor has prescribed INVIRASE after carefully studying your case, because he/she believes that you may benefit from this medication. This may not be true for other patients with HIV infection, even those who exhibit symptoms similar to yours. As with any prescription drug, INVIRASE should only be taken on the advice of a physician. Do not give your INVIRASE to any other person.

The recommended dose of INVIRASE is 1000 mg (5×200 mg capsules or 2×500 mg tablets) two times daily with Norvir (ritonavir) 100 mg two times daily, in combination with other antiretroviral agents.

INVIRASE must be taken with meals or up to 2 hours after a meal, but it is easiest to remember if you take it with your meals. When INVIRASE is taken without food, the amount of INVIRASE in the blood is lower and may not fight HIV as well.

INVIRASE capsules and tablets should be swallowed unchewed, with water or some other non-alcoholic drink. You should avoid excessive consumption of alcohol during your treatment with INVIRASE. Follow the advice of your doctor. Do not discontinue therapy or alter your dosing without consulting your doctor.

Overdose

In cases of overdose or suspected overdose, contact the poison control centre or your physician immediately.

Missed dose

The missed dose should be taken as soon as you remember, then just carry on with your regular dosing schedule. However, do not take 2 doses at the same time. If you are unsure what to do, consult your doctor or pharmacist.


Side Effects for Invirase and What to Do About Them

As with any drug, the beneficial effects of INVIRASE may be accompanied by unwanted effects (also known as side-effects or adverse events). It is often difficult to determine whether these adverse events are the result of taking INVIRASE, an effect of your HIV-infection, or a side-effect from other drugs being used to treat the HIV-infection. It is very important however, to inform your physician of any change in your condition.

People treated with INVIRASE in combination with Norvir (ritonavir) may have side effects. The majority of these have been described as mild. In clinical studies of patients who received saquinavir in combination with Norvir and other HIV drugs the side effects seen most often were: nausea, diarrhea, body fat changes, vomiting, tiredness, and stomach pain.

Regular blood testing to detect any abnormalities with your liver, pancreas or blood is a recommended part of your therapy with INVIRASE. These abnormalities do not always cause side effects that you can detect yourself, so it is very important to adhere to the blood testing schedule recommended by your doctor.

In hemophiliacs, there have been reports of increased bleeding episodes among patients treated with INVIRASE or other drugs of this class (protease inhibitors). If you suffer from hemophilia, remember to report all bleeding episodes to your doctor.

When INVIRASE is taken with ritonavir, some patients may experience large increases in triglyceride and lipid levels. The long-term chance of getting complications such as heart attack and stroke due to increases in triglyceride and cholesterol levels caused by protease inhibitors is not known at this time.

Changes in body fat have been seen in some patients taking antiretroviral therapy. These changes may include increased amount of fat in the upper back and neck (“buffalo hump”), breasts, and around the trunk. Loss of fat from the legs, arms, and face may also happen. The cause and long-term health effects of these conditions are not known at this time. Side effects known to be associated with other drugs used to treat HIV may still occur when INVIRASE is used in combination with these medicines. However, INVIRASE does not appear to increase the frequency or severity of the unwanted effects. These side effects (associated with drugs such as ddC and AZT) include skin rash, inflammation or sores in the mouth and disturbances of the nerves (especially in the hands and feet). These disturbances may take the form of numbness, pins and needles, or shooting/burning pain in the hands and feet. If you are concerned about these or any other unexpected effects experienced while taking INVIRASE, talk to your doctor or pharmacist.

This is not a complete list of side effects. For any unexpected effects while taking INVIRASE contact your doctor or pharmacist.


Technical Information