Azilect Medication Information:

Price Break On Azilect
Generic is available for less money: Generic Rasagiline (generic equivalent to Azilect)

Azilect medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Azilect 0.500 mg
Azilect 1 mg

About Azilect

What Azilect is used for

Your physician has prescribed AZILECT (rasagiline mesylate) 0.5 mg or 1 mg tablets. AZILECT relieves the signs and symptoms of Parkinson’s disease as initial therapy for early disease and as add-on therapy to levodopa in later stages of the disease.

Before you begin using AZILECT, make sure you understand all the information provided about its possible benefits and risks. If you do not understand any of the information provided, contact your doctor for further clarification.

What Azilect does

AZILECT is used to treat the signs and symptoms of Parkinson’s disease as monotherapy (without levodopa) or as adjunct therapy (with levodopa).

Parkinson’s disease is a disorder of the central nervous system caused by a lack of dopamine—a substance in the brain used to send messages to your muscles to make them move. AZILECT belongs to a class of drugs called monoamine oxidase B inhibitors. AZILECT works by blocking the breakdown of dopamine in the brain.

When Azilect should not be used

Do not use AZILECT if you:

  • are allergic to it or any of the components of its formulation (see list of components at the end of this section). Stop taking the drug and contact your doctor immediately if you experience an allergic reaction (e.g., skin rash, hives) or any severe or unusual side effects.

  • have moderate-to severe liver disease

  • have pheochromocytoma (a type of tumour)

  • plan to undergo elective surgery requiring general anesthesia. Do not undergo elective surgery requiring general anesthesia while on AZILECT. You should discontinue AZILECT at least 14 days prior to elective surgery. If surgery is necessary sooner, benzodiazepines, mivacurium, fentanyl, morphine, and codeine may be used cautiously.

Do not use AZILECT at the same time, or within 2 weeks before or after antidepressants:

  • Specifically selective serotonin reuptake inhibitors (SSRIs), SNRIs, tricyclic or tetracyclic antidepressants [e.g. Prozac (fluoxetine), Luvox (fluvoxamine), Zoloft (sertraline), Paxil (paroxetine), and Remeron (mirtazapine)]

Wait at least 5 weeks after stopping fluoxetine treatment before starting treatment with AZILECT.

Do not use AZILECT if you are taking any of the following medications:

  • Sympathomimetic amines including amphetamines, cold medications, and weight-reducing products that contain vasoconstrictors (e.g., pseudoephedrine, phenylephrine and ephedrine)

  • Cyclobenzaprine (a tricyclic muscle relaxant)

  • Demerol (meperidine, pethidine)

  • Dextromethorphan (an over-the-counter cough suppressant)

  • Other MAO inhibitors for the treatment of Parkinson's disease or for any other indication

  • Pain medications (notably tramadol, methadone, and propoxyphene)

  • St. John's wort

What the medicinal ingredient is

The active substance is rasagiline. Each tablet contains 0.5 mg or 1 mg rasagiline (as mesylate).

What the nonmedicinal ingredients for Azilect are

Each AZILECT tablet also contains the following inactive ingredients: colloidal silicon dioxide mannitol, starch, pregelatinized starch, stearic acid and talc.

What dosage forms Azilect comes in

AZILECT tablets are white to off-white, round, flat, bevelled tablets, marked with “GIL 0.5” on one side and plain on the other side for the 0.5 mg tablet or “GIL 1” on one side and plain on the other side for the 1 mg tablet.

Warnings and Precautions

Before you use AZILECT, tell your doctor if you:

  • plan to undergo elective surgery requiring general anaesthesia. (See “When it should not be used:”.)

  • are also taking levodopa, as there is the possibility of increased difficulty with movement. Your doctor may lower the dose of your levodopa therapy.

  • have mild liver disease. Your dose may be reduced to 0.5 mg/day.

  • are under the age of 18.

  • are pregnant or planning to become pregnant. AZILECT should be used during pregnancy only if clearly needed.

  • are breast-feeding.

AZILECT may be taken if you have mild kidney disease but should not be taken if you have moderate to severe kidney impairment.

Interactions with Azilect

See the When it should not be used: section for important safety information about drugs not to use at the same time as AZILECT.

Please ask your doctor or pharmacist for advice if you are taking or have recently taken any other medicines, even those obtained without a prescription. AZILECT may interact with the following medications or you might require a dose adjustment:

  • Antidepressants

  • Ciprofloxacin (an antibiotic) or other CYP1A2 inhibitors—if you take the antibiotic ciprofloxacin or other CYP1A2 inhibitors you should use 0.5 mg daily of AZILECT.

  • Demerol (meperidine) or some other pain medications

  • Dextromethorphan (an over-the-counter anti-cough drug)

  • Levodopa—levodopa dose may be reduced

  • Other MAOIs (monoamine oxidase inhibitors)

  • Sympathomimetic amines including amphetamines, some decongestants, cold remedies, and weight loss products

Proper Use of Azilect

Usual dose

Take AZILECT exactly as instructed by your doctor. You should talk with your doctor or pharmacist if you are unsure.

The recommended dose of AZILECT is 0.5 mg or 1 mg taken orally once daily either with or without food. Your doctor will determine which dose is appropriate for you.

Do not take more then the maximum recommended daily dose of 1 mg. Taking more than 1 mg may cause serious side effects which could include a severe headache, seizures, and a sudden rise in blood pressure. Should you experience these side effects seek immediate emergency medical assistance. For any other unusual symptoms you have not had before, call your doctor immediately.


If you take more AZILECT than you should: If you think that you may have taken too many AZILECT tablets, contact your doctor or pharmacist immediately. Take the AZILECT carton/bottle with you to show the doctor or pharmacist.

Missed dose

If you forget to take AZILECT: If you have forgotten to take a dose of AZILECT take the next dose at the usual time. Do not take a double dose to make up for the one you missed.

Side Effects for Azilect and What to Do About Them

Like all medicines, AZILECT can have side effects.

The most commonly observed side effects that occurred in patients receiving AZILECT as monotherapy in placebo controlled clinical trials were: flu like symptoms, joint pain, depression, indigestion and falls. In patients receiving AZILECT as adjunct to levodopa therapy the most common side effects in placebo controlled clinical trials were: lack of coordination, accidental injury, weight loss, posture-dependant low blood pressure, vomiting, loss of appetite, joint pain, abdominal pain, nausea, constipation, dry mouth, rash, bruising, trouble sleeping, and abnormal skin sensation.

Studies have shown that patients with Parkinson’s disease have a higher risk of developing skin cancer than the general population, although it is unclear whether increased risk is due to Parkinson’s disease itself or to drugs used to treat Parkinson’s disease. Nevertheless you should examine your skin regularly to check for any unusual growth or discoloration. Ask your doctor if you are unsure what to look for. Ideally, periodic skin examinations should be performed by a dermatologist.

AZILECT may cause hallucinations. Tell your doctor immediately if this happens to you while taking AZILECT.

Taking more than 1 mg may cause serious side effects which could include a severe headache, seizures, and a sudden rise in blood pressure. Should you experience these side effects seek immediate emergency medical assistance. For any other unusual symptoms you have not had before or are not mentioned here, contact your doctor or pharmacist immediately.

This is not a complete list of side effects. For any unexpected effects while taking AZILECT, contact your doctor or pharmacist.


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