Sinemet Medication Information:

Price Break On Sinemet
Generic is available for less money: Generic Levodopa/carbidopa

Sinemet medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Sinemet 100mg/10mg
Sinemet 100mg/25mg
Sinemet CR 200mg/50mg

About Sinemet

SINEMET is the brand name for the substance—levodopa and carbidopa, available only on prescription from your physician.

What Sinemet is used for

Your physician has prescribed SINEMET to treat the symptoms of Parkinson’s disease.

Parkinson’s disease is a chronic disorder characterized by slow and unsteady movement, muscular stiffness, and tremor. If untreated, Parkinson’s disease can cause difficulty in performing normal daily activities.

What Sinemet does

SINEMET is a combination of levodopa, the metabolic precursor of dopamine, and carbidopa, an aromatic amino acid decarboxylase inhibitor. It treats the symptoms of Parkinson’s disease.

It is believed that the symptoms of Parkinson’s disease are caused by a lack of dopamine, a naturally occuring chemical produced by certain brain cells. Dopamine has the role of relaying messages in certain regions of the brain that control muscle movement. Difficulty in movement results when too little dopamine is produced.

Levodopa acts to replenish dopamine in the brain, while carbidopa ensures that enough levodopa gets to the brain where it is needed. In many patients, this reduces the symptoms of Parkinson’s disease.

When Sinemet should not be used

Do not take SINEMET, if you:

  • are allergic to any of its ingredients

  • have any suspicious skin lesions (moles) which have not been examined by your physician or if you have ever had skin cancer

  • are being treated with certain MAO inhibitor drugs, such as for depression, within the last 2 weeks

  • have narrow-angle glaucoma

  • have untreated heart, liver, kidney, lung, blood or hormonal disease

  • have been told that you should not take sympathomimetic drugs such as isoproterenol, amphetamines, epinephrine or cough and cold medications containing drugs related to epinephrine

What the medicinal ingredients for Sinemet are

Levodopa and carbidopa.

What the important nonmedicinal ingredients for Sinemet are

Corn starch, magnesium stearate, microcrystalline cellulose, pregelatinized starch.

SINEMET 100/10 tablets and SINEMET 250/25 tablets also contain FD&C Blue #2. SINEMET 100/25 tablets also contain D&C yellow #10 and FD&C yellow #6.

What dosage forms Sinemet comes in

Tablets (levodopa/carbidopa): 100 mg/25 mg (yellow), 100/10 (dark dapple-blue) and 250/25 (light dapple-blue).

Warnings and Precautions

Serious Warnings and Precautions

Some people feel sleepy, drowsy, or, rarely, may suddenly fall asleep without warning (i.e. without feeling sleepy or drowsy) when taking SINEMET. During treatment with SINEMET take special care when you drive or operate a machine. If you experience excessive drowsiness or a sudden sleep onset episode, refrain from driving and operating machines, and contact your physician.

Studies of people with Parkinson’s disease show that they may be at an increased risk of developing melanoma, a form of skin cancer, when compared to people without Parkinson’s disease. It is not known if this problem is associated with Parkinson’s disease or the drugs used to treat Parkinson’s disease. Therefore, patients treated with SINEMET should have periodic skin examinations.

BEFORE taking SINEMET, tell your physician or pharmacist if you

  • have or have had any medical conditions including: allergies; depression or mental disturbances; lung, kidney, liver, heart or hormonal problems; skin cancer or suspicious skin lesions; ulcer in your gut (called “duodenal” or “peptic ulcer”; convulsions/seizures; or glaucoma

  • have previously been treated with levodopa

  • are pregnant or plan to become pregnant

  • are breastfeeding or wish to breastfeed

  • are going to have an operation that requires general anesthesia

  • drive or operate machinery

It is not recommended to use SINEMET while you are pregnant or breast-feeding.

It is not known what effect SINEMET may have on human pregnancy. Levodopa, one of the components of SINEMET, is passed into human milk. If you are pregnant, may become pregnant or intend to breast-feed, tell your physician, who will help you weigh the benefits of the drug for you against possible risks to your baby.

As you improve on SINEMET, you may increase your physical activity gradually and with caution related to any other medical conditions you may have.

SINEMET should not be given to children under 18 years of age.

Interactions with Sinemet

Your physician or pharmacist has a more complete list of medicines to avoid while taking SINEMET. Tell your physician about all medicines you are taking or plan to take, including those obtained without a prescription.

Although SINEMET can generally be given with other medicines, there are exceptions. Your physician may warn against use with certain medications used to treat psychiatric conditions or mental depression, tuberculosis, high blood pressure, muscle spasms or convulsions.

It is particularly important to tell your physician if you are taking:

  • antihypertensive drugs (used to treat elevated blood pressure)

  • medications used to treat psychiatric conditions or mental depression (including phenothiazines, butyrophenones, risperidone, phenytoin, papaverine, selegiline, tricyclic antidepressants and monoamine oxidase inhibitors)

  • isoniazid

  • metoclopramide

  • iron salts (such as multivitamins tablets) which may reduce the amount of carbidopa and/or levodopa available to the body

A change in diet to foods that are high in protein (such as meat, fish, dairy products, seeds and nuts) may delay the absorption of levodopa and SINEMET may not work as well as it should.

Proper Use of Sinemet

Usual dose

The dosage of SINEMET is variable and your physician will adjust it according to the severity of your disease and your response to treatment.

SINEMET tablets may be broken in half if so prescribed.

SINEMET is an immediate-release formulation of levodopa-carbidopa that is designed to begin release of ingredients within 30 minutes. For best results take SINEMET every day. It is important to carefully follow your physician’s advice on how much SINEMET to take and how often to take it. Promptly inform your physician of any change in your condition such as nausea or abnormal movements, as this may require an adjustment in your prescription.

Do not change the dose regimen prescribed by your physician and do not add any additional antiparkinson medications, including other levodopa-carbidopa preparations, without first consulting your physician.

Do not stop taking this medicine abruptly or lower the dosage without checking with your physician. If you suddenly stop or reduce your dosage you may experience the following symptoms: stiff muscles, high temperature (fever) and mental changes.


In case of an overdose, contact your physician immediately so that medical attention may be given promptly.

For management of a suspected drug overdose, contact your regional Poison Control Centre.

Missed dose

Try to take SINEMET as prescribed. However, if you have missed a dose, take it as soon as you remember. If it is almost time to take your next tablet, do not take the missed tablet, but resume your normal schedule.

Side Effects for Sinemet and What to Do About Them

SINEMET is generally well tolerated. Like any other medicine, however, SINEMET may have unintended or undesirable effects, so called side-effects.

Very rare but serious side effects that have been reported include sudden sleep onset episodes. (See Warnings and Precautions:.)

Certain side effects that have been reported with SINEMET may affect some patients’ ability to drive or operate machinery.

SINEMET can cause somnolence (excessive drowsiness) and sudden sleep onset episodes. Therefore you must refrain from driving or engaging in activities where impaired alertness may put yourself or others at risk of injury or death (e.g. operating machines) until such recurrent episodes and somnolence have resolved (see Warnings and Precautions:).

The most frequent side effects are: abnormal movements including twitching or spasms (which may or may not resemble your Parkinson’s symptoms), and nausea.

Other possible side effects include: mental changes, dream abnormalities, hair loss, diarrhea, dizziness, vomiting, loss of appetite, and slow movement (see Warnings and Precautions:). Occasionally, dark colour (red, brown or black) may appear in your saliva, urine or sweat after you take SINEMET.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Most common Abnormal involuntary movements, such as spasms or twitching    
Common Hallucinations (seeing or hearing things that are not there)    
Rare Allergic reactions [red skin, hives, itching, swelling of the lips, face, tongue, throat, trouble breathing or swallowing]    
Excessive sleepiness; falling asleep without warning    
Impulse control symptoms such as increased sexual urges and/or behaviours, compulsive gambling, binge eating    
Changed patches of pigmented skin, including irritated or irregular moles, or moles in which you have noticed changes (melanoma)    
Uneven (irregular) heart beat or palpitations    
Feeling of lightheadednesas when standing quickly    

This is not a complete list of side effects. For any unexpected effects while taking SINEMET, contact your doctor or pharmacist.


Technical Information