Prolopa

Prolopa Medication Information:

Prolopa medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Prolopa 25mg/100mg
Prolopa 50mg/200mg
Prolopa 12.5mg/50mg

About Prolopa

What Prolopa is used for

PROLOPA belongs to a group of medicines called antiparkinson agents which are used to treat the signs and symptoms of Parkinson's disease. Signs and symptoms of Parkinson's disease include: shaking (tremor), slowness in performing activities of daily living (bradykinesia), muscle stiffness (rigidity) and mood changes (depression).

What Prolopa does

The symptoms of Parkinson's disease are caused by a deficiency of a natural substance (dopamine) in the part of the brain affected by Parkinson's disease. PROLOPA helps to replace this substance.

When Prolopa should not be used

  • If you have had an allergic reaction to any of the ingredients listed in the ingredients section of this leaflet (see What the medicinal ingredients are: and What the important nonmedicinal ingredients are:)

  • If you have been told that you should not take sympathomimetic drugs such as, isoproterenol, amphetamine, epinephrine, or cough and cold medications containing drugs related to epinephrine

  • If you have taken a monoamine oxidase inhibitor medicine within the last 2 weeks

  • If you have untreated heart, liver, kidney, lung, blood or hormonal disease

  • If you have glaucoma

  • If you are being treated for severe mental problems

  • If you are under the age of 25

  • If you are pregnant or of childbearing potential in the absence of adequate contraception

What the medicinal ingredients for Prolopa are

Levodopa and benserazide in combination.

What the important nonmedicinal ingredients for Prolopa are

Gelatin, indigotine, iron oxide, magnesium stearate, mannitol (50-12.5 capsule only), microcrystalline cellulose, povidone, talc, titanium dioxide.

What dosage forms Prolopa comes in

PROLOPA (levodopa and benserazide combination) is available as:

50-12.5 capsules (light grey and blue; 50 mg levodopa and 12.5 mg benserazide)

100-25 capsules (blue and pale pink; 100 mg levodopa and 25 mg benserazide)

200-50 capsules (blue and caramel-color; 200 mg levodopa and 50 mg benserazide)


Warnings and Precautions

Some people feel sleepy, drowsy, or, rarely, may suddenly fall asleep without warning (i.e. without feeling sleepy or drowsy) when taking PROLOPA. During treatment with PROLOPA take special care when you drive or operate a machine. If you experience excessive drowsiness or a sudden sleep onset episode, refrain from driving and operating machines, and contact your physician.

Studies of people with Parkinson's disease show that they may be at an increased risk of developing melanoma, a form of skin cancer, when compared to people without Parkinson's disease. It is not known if this problem is associated with Parkinson's disease or the drugs used to treat Parkinson's disease. Therefore, your doctor should perform periodic skin examinations.

BEFORE you use PROLOPA talk to your doctor or pharmacist if you:

  • have or have had any other health problems including: convulsions, diabetes, stomach ulcers, depression or other psychological disorders, osteoporosis, clots in your veins, irregular heart rhythm or history of heart attack, glaucoma, skin cancer or suspicious skin cancer

  • drive or operate machinery

  • are pregnant or plan to become pregnant

  • are breast-feeding or wish to breast-feed

  • are allergic to any other medicines, foods, dyes or preservatives

  • are going to have an operation that requires general anesthesia (see Interactions with This Medication:)


Interactions with Prolopa

Drugs that may interact with PROLOPA include:

  • sympathomimetic drugs, such as cough and cold medications containing epinephrine, isoproterenol or amphetamine

  • blood pressure lowering medications

  • other antiparkinsonian medications

  • some medications used to treat mental problems

  • general anesthetics with halothane. If you know you are going to have an operation, that requires this type of anesthesia, you should stop PROLOPA 12-48 hours beforehand.

  • iron tablets or multivitamin tablets containing iron

Protein-rich diets (for example, a lot of meat, poultry or fish) may reduce the beneficial effects of PROLOPA.


Proper Use of Prolopa

Usual dose

Your doctor will decide how many PROLOPA capsules you will need to take each day.

You should always follow your doctor's instructions about how many PROLOPA capsules to take each day and when you should take them.

You should swallow the capsules whole, with water. Do not open capsules or dissolve in liquid.

The amount of PROLOPA your doctor prescribes will depend on your individual symptoms and your response to treatment. When you first start taking PROLOPA the amount you take will be increased gradually. The amount has to be carefully adjusted for each person as your Parkinson's symptoms will not be controlled if you take too little PROLOPA and if you take too much PROLOPA, you may experience unwanted side effects. It may be several weeks before the best dose for you is reached.

Keep taking your medication, as instructed, until your doctor tells you to stop.

Do not stop taking this medication abruptly.

Overdose

If you take more than the scheduled dose, contact your doctor or pharmacist immediately to find out what needs to be done.

Missed dose

If you have missed a dose, take it as soon as you remember. If it is almost time to take your next capsule, do not take the missed capsule, but carry on with your regular schedule.


Side Effects for Prolopa and What to Do About Them

Like all medications PROLOPA capsules can cause some side effects. You may not experience any of them. For most patients these side effects are likely to be minor and temporary. However, some may be serious. Consult your doctor if you experience these or other side effects.

  • The most common serious side effects are abnormal involuntary movements such as twitching or spasms which may or may not resemble your Parkinson's symptoms. It may help if the daily dose is reduced or smaller doses are taken more frequently.

  • At the beginning of treatment, nausea, vomiting or diarrhea can occur.

  • Psychiatric problems are common in people with Parkinson's disease and may occur during treatment with PROLOPA. These may include depression, confusion, anxiety, agitation, hallucinations, nightmares, and other mental changes.

  • Other possible side effects include: changes in heart rhythm, changes in blood pressure, faintness, sleepiness, sweating, rash, itching, dark color in your sweat or urine. Very rarely changes in behaviour, such as compulsive gambling or change in sexual desire, may occur.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Very rare Falling asleep without warning    
Impulse control symptoms, increased libido including hypersexuality, pathological gambling    

This is not a complete list of side effects. For any unexpected effects while taking PROLOPA, contact your doctor or pharmacist.


 

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