Comtan 200 mg

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Best Value On Brand Comtan 200 mg
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Comtan 200 mg Prescription Required
100 tabs for $171.02 ($1.71 per tab)
Comtan from online pharmacy: South Africa
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Drugs in other countries are sometimes sold using different trade names which will appear on the packaging. This product is sold in other countries as:

  • Comtess

Save money today when you buy Comtan 200 mg online from The Drug Company. If you have any questions about ordering, call 1-888-254-3038 toll free and speak with a customer service representative. You can also use the Live Chat feature to ensure you find the medication you are looking for. Either way, you can arrange for home delivery of your prescription order, by phone or entirely online. Your doctor will be able to provide you with the prescription you need for Comtan 200 mg.

What is COMTAN used for?

COMTAN, also known as entacapone, is used together with levodopa/carbidopa or levodopa/benserazide to treat people with Parkinson's disease in whom the effect of each levodopa dose becomes shorter and who subsequently experience fluctuations in the symptoms of Parkinson's disease (end-of-dose “wearing-off”).

In Parkinson's disease the amount of dopamine is decreased in certain areas of the brain and oral levodopa is given to compensate for this decrease. Levodopa is converted to dopamine in the brain, but part of the dose of levodopa is broken down by enzyme to an inactive compound before it reaches the brain. COMTAN inhibits this enzymatic degradation of levodopa, and therefore increases the amount of levodopa reaching the brain. When taken together with levodopa, COMTAN prolongs the efficacy of levodopa therapy in alleviating the symptoms of Parkinson's disease. COMTAN is used in patients in whom the effect of each levodopa dose becomes shorter (“wearing-off”) and who subsequently experience fluctuations in the symptoms of Parkinson's disease. COMTAN has no antiparkinsonian activity without levodopa.

What should I know before taking COMTAN?

Some people feel sleepy, drowsy, or, rarely, may suddenly fall asleep without warning (i.e. without feeling sleepy or drowsy) when taking COMTAN in combination with levodopa and other drugs used to treat Parkinson's disease. Take special care when you drive or operate a machine. If you experience excessive drowsiness or a sudden sleep onset episode, refrain from driving and operating machines, and contact your physician.

Studies of people with Parkinson's disease show that they may be at an increased risk of developing melanoma, a form of skin cancer, when compared to people without Parkinson's disease. It is not known if this problem is associated with Parkinson's disease or the drugs used to treat Parkinson's disease. Therefore, your doctor should perform periodic skin examinations.

Using COMTAN safely

You should not take COMTAN if you:

  • Have a history of allergic reactions to entacapone or any other components of the COMTAN tablet (see What does COMTAN contain?).

  • Are taking certain antidepressants (both MAO-A and MAO-B inhibitors simultaneously, or non-selective MAO-inhibitors). If you are taking antidepressants and need further information, please ask your doctor or your pharmacist whether your antidepressive medication can be taken together with COMTAN.

  • Have a history of Neuroleptic Malignant Syndrome (NMS) (rare reaction to antipsychotic medicines) and/or non-traumatic rhabdomyolysis (rare form of muscle disorder).

  • Have pheochromocytoma (a tumor of the adrenal gland), because it may increase the risk of severe hypertensive reactions.

  • Have liver disease.

  • Are pregnant (see below).

  • Are breast-feeding (see below).

  • Are under 18 years of age.

If you think you may be allergic, ask your doctor for advice.

If any of these apply to you, tell your doctor before taking COMTAN.

What does your doctor need to know about you?

To be sure that you can use COMTAN safely, your doctor must know if you:

  • have any other illnesses

  • have ever had abnormal liver function tests

  • have any allergies to medicines, food, dyes, or preservatives

  • are taking or have recently taken any medications, including those not prescribed by a doctor. It may be necessary to change the dose, take other precautions, or perhaps stop one of the medicines. This applies to both prescription and non-prescription medicines, especially rimiterol, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa, apomorphine, and paroxetine.

  • are taking any iron supplements. Similarly to levodopa, COMTAN may impair the absorption of iron from the gastrointestinal tract. Therefore, COMTAN and iron-containing medicinal products should be taken at least 2 to 3 hours apart.

COMTAN tablets contain a sugar called sucrose. Therefore, if you have been told by your doctor that you have an inherited intolerance to sucrose or fructose, you should not take COMTAN.

Are you pregnant or breast-feeding?

COMTAN is not recommended if you are pregnant. There is no experience in using COMTAN in pregnant women. It is therefore important to tell your doctor immediately if you think you may have become pregnant, or are planning to become pregnant.

COMTAN is not recommended if you are breast-feeding, because it is not known whether COMTAN is excreted into breast milk. Tell your doctor if you are breast-feeding, so that other treatment options can be tried.

How to take COMTAN?

Follow your doctor’s instruction carefully. Do not exceed the recommended dosage.

If you have any concerns about the schedule for taking your medication, talk to your doctor or pharmacist to help you sort it out.

COMTAN should always be used in combination with levodopa preparations, either levodopa/carbidopa or levodopa/benserazide. You may also use other antiparkinsonian drugs simultaneously as advised by your doctor.

The usual dose of COMTAN is one 200 mg tablet with each levodopa dose. The maximum recommended dose is 200 mg 8 times a day, i.e., 1600 mg of entacapone.

Your doctor will tell you exactly how many tablets of COMTAN to take.

Depending on how you respond to the treatment, your doctor may suggest a higher or lower dose.

COMTAN can be taken with or without food. Do not break or crush the tablets.

What to expect when you start taking COMTAN?

Soon after beginning and during treatment with COMTAN, you may experience an increase in uncontrolled movements (dyskinesia), nausea and abdominal pain. These effects may also be more common with higher doses (1400 to 1600 mg/day) than with lower doses. This is because COMTAN increases the availability of levodopa and enhances both its effectiveness and side effects. Therefore, if, for example, you notice a disturbing increase in involuntary movements (dyskinesias) after starting treatment with COMTAN, you should contact your doctor for possible adjustment of your levodopa dosage to decrease the severity and frequency of these effects.

Driving and using machines

COMTAN taken together with levodopa may lower your blood pressure, which may make you feel light-headed or dizzy. You should not drive a car or operate machinery until you are reasonably certain that COMTAN does not affect your ability to carry out these activities.

See also What should I know before taking COMTAN?

What happens if a dose is missed?

To obtain the maximum benefit from your antiparkinsonian therapy always take all medicines, including COMTAN, exactly as prescribed by your doctor. However, if you have forgotten to take the COMTAN tablet with your levodopa dose, you should continue the treatment by taking the next COMTAN tablet with your next levodopa dose. If you have missed several doses, please inform your doctor immediately and follow the advice given to you.

Do not change the dose of COMTAN unless instructed by your doctor.

What to do in case of overdose?

If you have accidentally taken too many tablets, contact your regional Poison Control Centre and talk to your doctor right away. You may require medical attention.

Effects when treatment with COMTAN is stopped

Do not stop taking COMTAN unless your doctor tells you to. In such case, your doctor may need to re-adjust the dosage of your other antiparkinsonian medication. Abrupt discontinuation of both COMTAN and other antiparkinsonian medication may result in unwanted side effects, such as severe muscular stiffness, high fever and altered consciousness.

Side effects for Comtan of COMTAN

Like all medicines, COMTAN may cause unwanted reactions, so-called side effects. The most frequent side effects reported with COMTAN are involuntary movements (dyskinesias), nausea, dizziness, diarrhea, abdominal pain, constipation and dryness of the mouth. These adverse events are most likely to occur when you begin treatment with COMTAN and are usually mild to moderate and rarely necessitate discontinuation of the treatment. COMTAN can also cause hallucinations, severe diarrhea, confusion, somnolence, sweating, and discoloration of urine, sweat, saliva, hair, beard, skin and nails. Very rarely changes in behavior, such as compulsive gambling or change in sexual desire, including excessive sexual activity, may occur in patients treated with drugs for Parkinson's disease.

Tell your doctor right away if you develop any of the following symptoms while taking COMTAN:

  • Rash (that might be severe),

  • Hallucinations,

  • Severe diarrhea, with or without weight loss,

  • Muscle pain, prolonged muscle contraction, muscle weakness,

  • Prolonged stiffness,

  • Fever,

  • Yellowish skin, hair, nail or eye color,

  • Feeling unwell,

  • Increasing loss of appetite, weakness, exhaustion and weight loss in a short time period,

  • Confusion,

  • Excessive daytime sleepiness, sudden sleep onset episodes,

  • Severe muscular stiffness, high fever and altered consciousness.

Together with levodopa, COMTAN may lower your blood pressure and cause postural (orthostatic) hypotension (a decrease in your blood pressure when standing up rapidly after sitting or lying down), with or without symptoms such as dizziness, nausea, syncope (fainting) and sweating. Hypotension may occur more frequently during the start of treatment with COMTAN. Therefore, you should avoid standing rapidly after sitting or lying down, especially after prolonged periods. You should also be careful if you are taking other medicinal products that may decrease blood pressure.

The color of your urine may be turned reddish-brown by COMTAN. However, this is harmless and no action is required.

Severe diarrhea while taking COMTAN can cause significant loss of weight for some individuals. In some cases diarrhea and weight loss have been caused by inflammation of the colon that occurred during treatment with COMTAN. Therefore, it is important to tell your doctor if you have diarrhea so that the cause of your symptoms can be determined. Your weight should also be closely monitored. Your treatment may need to be adjusted to avoid diarrhea and excessive weight loss.

If you experience increasing loss of appetite, weakness, exhaustion and weight loss in a relatively short period of time after starting treatment with entacapone, contact your doctor. He/she may decide to do a general medical evaluation, including blood tests to check liver function.

Abnormal results of blood tests, such as decrease in red blood cells, have been observed in people taking COMTAN.

COMTAN may also cause other adverse events. If you have any questions or concerns about these effects you should talk to your doctor or pharmacist.

What does COMTAN look like?

COMTAN (entacapone) 200 mg is a brownish-orange, unscored, oval-shaped film-coated tablet embossed with “COMTAN”' on one side.

What does COMTAN contain?

COMTAN tablets contain 200 mg of entacapone. In addition to entacapone, the COMTAN tablet contains the following nonmedicinal ingredients: Core: croscarmellose sodium, hydrogenated vegetable oil, magnesium stearate, mannitol, microcrystalline cellulose. Coating: glycerol 85%, hydroxypropylmethyl cellulose, polysorbate 80, red iron oxide, sucrose, titanium dioxide, yellow iron oxide.

Expiry Date

Do not take COMTAN past the expiry date shown on the bottle.

Technical Information