Zometa 4mg/5mL

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Best Value On Brand Zometa 4mg/5mL
Price: $716.14 per vial!
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1 vials for $716.14 ($716.14 per vial)
Zometa from online pharmacy: South Africa
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Drugs in other countries are sometimes sold using different trade names which will appear on the packaging. This product is sold in other countries as:

  • ZOMERA Injection

Order Zometa 4mg/5mL today and have it delivered quickly and discreetly to your home. For many medication products on our website, a prescription is often required. In other cases, no prescription is required for OTC (over the counter) drugs. If you desire to save on drugs, one alternative to your local store is to buy from an online pharmacy like The Drug Company. The Drug Company offers medications from a wide selection of licensed pharmacies, including a Canadian pharmacy. Many people trust prescription medications from Canada, as well as all of the pharmacies in our network.

About Zometa

What Zometa is used for

ZOMETA is used:

  1. to reduce the abnormal amount of calcium in the blood for example, in the presence of a tumor. This is because tumors can accelerate normal bone change in such a way that the release of calcium from bone is increased. This condition is known as tumor-induced hypercalcemia.

  2. to prevent or delay skeletal complications for example, fractures of the bone and bone pain requiring surgery or radiotherapy, due to bone metastases (cancer that has spread from the tumor to the bone) due to different types of tumors.

What Zometa does

ZOMETA is a member of a group of substances called bisphosphonates. These strongly bind to the bone and slow down the rate of bone change. In addition, ZOMETA may prevent bone destruction and uncontrolled bone growth associated with the tumor spreading to the bone.

When Zometa should not be used

You should not be given ZOMETA if you are pregnant or breast-feeding or if you have previously had an allergic reaction to zoledronic acid, other bisphosphonates (the group of substances to which ZOMETA belongs) or to any other ingredient contained in the formulation (see What the important nonmedicinal ingredients are:).

What the medicinal ingredient is

Zoledronic acid.

What the important nonmedicinal ingredients for Zometa are

Mannitol and sodium citrate.

What dosage forms Zometa comes in

ZOMETA is available as a concentrate in vials. Each vial of ZOMETA concentrate delivers 4 mg of zoledronic acid. It is available in cartons containing 1 vial.

Warnings and Precautions

If you are being treated with ZOMETA, you should not need be treated with another intravenous form of zoledronic acid (ie ACLASTA) or other bisphosphonates (e.g. alendronate, risedronate, clodronate, etidronate and pamidronate) at the same time.

Your doctor may request a dental examination prior to and while on treatment with ZOMETA. This may be required since some patients have experienced side effects following dental procedures (such as tooth extraction) while on ZOMETA; as well since patients with dental infections or periodontal disease (disease affecting surrounding tissues of a tooth) may be at increased risk of problems with their jaw bones following dental procedures (such as tooth extraction) while on treatment with ZOMETA.

BEFORE you use ZOMETA talk to your doctor or pharmacist if

  • if you have a kidney problem. Worsening of kidney function, including kidney failure (very rarely with fatal outcome), has been reported with the use of ZOMETA.

  • if you have a liver problem.

  • if you are or think you may be pregnant. ZOMETA should not be given during pregnancy.

  • if you are breast-feeding. ZOMETA should not be given if you are breast-feeding.

  • if you have asthma and are also allergic to acetylsalicylic acid (ASA).

  • if you had or have a heart problem. Cases of irregular heart beat (atrial fibrillation) have been observed with the use of ZOMETA.

  • if you have any dental problems or any dental procedures planned in the future.

After starting treatment with ZOMETA:

It is important that your doctor checks your progress at regular intervals. He or she may want to take repeated blood tests, especially after starting your treatment with ZOMETA. He or she may also suggest regular dental examinations. Regularly scheduled dental examinations are recommended.

If possible, you should not undergo tooth extraction or other dental procedures (excluding regular dental cleaning) while you are receiving treatment with ZOMETA. Please consult your doctor if a dental procedure (excluding regular dental cleaning) is required while you are receiving treatment with ZOMETA.

Driving and using machines

ZOMETA is unlikely to affect your ability to drive a car or to use machinery. However, some people have experienced sleepiness or dizziness. If this happens, you should not drive or operate any tools or machinery until you feel normal again.

Use in Children

So far children have not been treated with ZOMETA. Until further experience is gained, ZOMETA can only be recommended for use in adult patients.

Interactions with Zometa

Tell your doctor about any other medicines you are taking or have recently been taking, including any you have bought without a prescription. It is particularly important that your doctor knows if you are also taking aminoglycosides (a type of medicine used to treat severe infections), since the combination of these with bisphosphonates may cause the calcium level in the blood to become too low. Examples of aminoglycosides include gentamycin sulfate, tobramycin sulfate and streptomycin sulfate. It is also important to inform your doctor if you are taking any drugs that can have an effect on the kidney, since combining these drugs with ZOMETA may cause kidney function to deteriorate. Some examples of these drugs include acetylsalicylic acid (ASA), nonsteroidal anti-inflammatories (e.g. ibuprofen, diclofenac, celecoxib), diuretics, and Angiotensin-Converting Enzyme (ACE) inhibitors (e.g. enalapril, ramipril, fosinopril).

Proper Use of Zometa

Usual dose

ZOMETA is given by an infusion into a vein which should last no less than 15 minutes. The dose is usually 4 mg. If you have a kidney problem, your doctor may give you a lower dose depending on the severity of your kidney problem.

If you are being treated for multiple myeloma or bone metastases of solid tumors, you will be given one infusion of ZOMETA every three to four weeks. If you require antineoplastic therapy (therapy that blocks the growth of cancer cells), ZOMETA should be administered either prior to or after this treatment. You will also be asked to take an oral calcium supplement of 500 mg and a multivitamin containing at least 400 IU of Vitamin D daily. If you have a prior history of hypercalcemia or develop hypercalcemia during treatment with calcium and Vitamin D, you may be advised to discontinue taking calcium and Vitamin D supplements by your doctor.

Your doctor will decide how many infusions you need and how often you should receive them.

If you are being treated for Tumor-Induced Hypercalcemia (TIH), you will normally only be given one infusion of ZOMETA.


If you suspect that you have received doses higher than those recommended, talk to your doctor, pharmacist or nurse.

Side Effects for Zometa and What to Do About Them

Like all medicines, ZOMETA may have, in addition to its beneficial effects, some unwanted effects. These are usually mild and will probably disappear after a short time. The most common side effect is short-lasting fever. Other common side effects include gastrointestinal problems such as nausea, vomiting and thirst as well as loss of appetite.

Occasionally, patients experience a flu-like condition including fever, fatigue, weakness, and chills. In some patients, these symptoms may also be accompanied by bone, joint and/or muscle ache. In most cases, no specific treatment is required and the symptoms subside after a couple of hours or days. Skin reactions (redness and swelling) at the infusion site may occur. Cases of low blood pressure have also occasionally been reported; in very rare cases, this resulted in fainting.

Rare cases of rash, itching, chest pain, slow heart beat and confusion have been observed.

Very rare cases of severe bone, joint, and/or muscle pain, occasionally incapacitating, as well as sleepiness, irregular heart beat, difficulty breathing with wheezing or coughing, have been reported.

Blood tests indicating worsening of kidney function (higher levels of creatinine), including severe kidney failure have been reported with ZOMETA; such changes are also known to occur with other drugs of the bisphosphonate class. Your doctor will carry out blood tests to monitor your kidney function prior to each dose of ZOMETA. If these tests indicate worsening of kidney function, your doctor will withhold further treatment with ZOMETA until these tests have returned to normal.

The level of calcium, phosphate and/or magnesium in the blood may become too low, but your doctor will monitor this and take necessary measures.

Other bisphosphonates can cause breathing difficulties in patients with asthma who are allergic to aspirin. This has not been reported with ZOMETA, in studies done to date.

Eye pain, redness, photophobia (sensitivity to light), excessive tearing or decreased vision should be reported to your physician as they may indicate more serious eye complications which have been associated with ZOMETA.

Some patients have reported problems with their jaw bones while receiving cancer treatments that include ZOMETA. Dental hygiene is an important element of your overall cancer care and is important in possibly decreasing the chances of this type of problem occurring. Removable dentures should fit properly and should be removed at night. Please consult with your doctor if you experience pain in your mouth, teeth or jaw, or if your gums or mouth heals poorly. Any non-healing of a dental extraction site or chronic dental infection should be reported and assessed. In addition, if possible you should not undergo tooth extraction or other dental procedures (excluding regular dental cleaning) while on therapy with ZOMETA. Please consult your doctor if a dental procedure (excluding regular dental cleaning) is required while you are receiving treatment with ZOMETA.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Your medication should be withheld or stopped. Talk with your doctor.
Only if severe In all cases
Common Worsening of kidney function (higher levels of creatinine)    
Eye disorders (eye redness, excessive tearing)    
Uncommon Kidney failure (changes in urine color or absence of urine production, changes in kidney function laboratory tests, lower back pain, fatigue, nausea, loss of appetite)    
Eye disorders (eye pain, light sensitivity, or decreased vision)    
Allergic reaction to ZOMETA (swelling of the face, eyes or tongue, difficulty breathing, hives, rash, sudden onset of low blood pressure)    
Osteonecrosis of the jaw (numbness or feeling of heaviness in the jaw, poor healing of the gums especially after dental work, loose teeth, exposed bone in mouth, pain in the mouth, teeth or jaw, swelling or gum infections, bad breath)a     b
Very rare Severe bone, joint and/or muscle pain    
Difficulty breathing with wheezing or coughing    
Irregular heart beat (atrial fibrillation)    
a. While this is a serious side effect, it is not possible to determine if these events are related to ZOMETA or other bisphosphonates, to concomitant drugs or other therapies (e.g. chemotherapy, head and neck radiotherapy, corticosteroid or to other risk factors (e.g. anemia, infection, pre-existing oral disease). b. There are no data available to suggest whether discontinuation of bisphosphonate treatment reduces the risk of osteonecrosis of the jaw.

This is not a complete list of side effects. If you have any unexpected effects after receiving ZOMETA, contact your doctor or pharmacist.

Technical Information