Evista 60 mg

Generic Name: Raloxifene 60 mg
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Evista Facts

In September 2007, the FDA announced approval of the active ingredient in EVISTA for reduction of certain breast cancer risks.

EVISTA is manufactured and marketed by Eli Lilly and Company.

The active ingredient in EVISTA mimics estrogen in some tissues and has anti-estrogen activity in others.

EVISTA is the brand name of a medication containing the active ingredient raloxifene hydrochloride.


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Save money today when you buy Evista 60 mg online from The Drug Company. If you have any questions about ordering, call 1-888-254-3038 toll free and speak with a customer service representative. You can also use the Live Chat feature to ensure you find the medication you are looking for. Either way, you can arrange for home delivery of your prescription order, by phone or entirely online. Your doctor will be able to provide you with the prescription you need for Evista 60 mg.

Evista General Information

Evista is an oral medication that is used to prevent and/or treat osteoporosis in postmenopausal women by reducing or preventing bone loss.

How does Evista work?

Evista is from a group of medications known as selective estrogen receptor modulators and contains the active ingredient raloxifene hydrochloride. The female sex hormone estrogen controls and regulates cholesterol metabolism, breast tissue, and uterine tissue and bone tissue. On the onset of menopause however the levels of estrogen in the blood start to decrease and this affects all of the tissues that are regulated by it. In the case of bone tissue the decreasing levels of estrogen cause an increase in the breakdown of bone matter leading to a loss in bone density. This loss of bone density may lead to the development of osteoporosis, which makes bones weak and therefore more susceptible to breakage. Evista is used to both prevent and treat osteoporosis and it works by mimicking the natural effects of estrogen. It acts on estrogen receptors in the bone which reverses the excessive bone breakdown causing an increase in bone density in turn making bones stronger.

When/How is Evista taken/used/applied?

Evista must be taken according to the amounts prescribed by a doctor and can be taken either with or without food. It is suggested that Evista be taken at the same time every day. The medication usually comes packaged in blister cards which each contain 15 tablets labeled with a different day of the week to be taken. The tablets must be taken on each consecutive day of the week until finished unless otherwise instructed by a doctor. The medication must be stored at room temperature and away from heat and moisture to remain effective.

Side Effects of Evista

Evista like most medicines have common side effects and can affect different people in different ways. The following are the side effects that are known to be caused by this medicine, they are:

  • Nausea and vomiting
  • Abdominal Pain
  • Headache
  • Migraine
  • Pain or swelling in one or both legs
  • Unusual vaginal bleeding
  • Severe back pain
  • Pain or burning on urination
  • Joint pain
  • Hot flashes
  • Dizziness and/or spinning sensation
  • Chest pain and rapid breathing
  • Runny or stuffy nose
  • Problems with vision or speech

This list of side effects may not include new side effects reported by the manufacturer of the drug or recent findings by the FDA.

Other Brand Names for Evista:

Evista is also sold as its generic name raloxifene.

Safety Information:

There are several groups of women that should not use Evista, they are:

  • Women with severely decreased kidney function
  • Women with decreased liver function
  • Women who have vaginal bleeding of an unknown cause
  • Women who are pregnant or breastfeeding
  • Women who show signs of endometrial cancer
  • Women who have the possibility of getting pregnant
  • Women who have blood clots in the lungs (pulmonary embolism), in the eye (renal vein thrombosis) or in the leg (deep vein thrombosis)
  • Evista should also not be taken by anyone who is allergic to any of the ingredients contained in the medicine.

Dosage:

Evista is in a capsule tablet/pill form and is administered in 60 mg strength.

Visual Description:

Evista is a white solid capsule tablet and has "LILLY 4165" imprinted on one side.

About Evista

What Evista is used for

EVISTA is used to treat or to prevent osteoporosis in postmenopausal women.

What is Osteoporosis?

Osteoporosis is a thinning and weakening of the bones making the bones more likely to break. It is common in women after menopause or after removal of the ovaries because of the decrease in estrogens. A variety of risk factors may promote osteoporosis. These include:

  • Caucasian or Asian descent

  • Slender build

  • Early menopause

  • Smoking

  • Drinking alcohol

  • A diet low in calcium

  • Lack of exercise

  • A family history of osteoporosis

The greater the number of risk factors, the greater the probability of developing osteoporosis.

Initially osteoporosis usually does not cause any symptoms, but if left untreated may result in fractures. While most fractures are painful, fractures of the spine may not be noticed until they result in loss of height or a stooped posture. The fractures may occur as the result of normal every day activity or from minor injuries, which would ordinarily not result in broken bone.

How can osteoporosis be prevented or treated?

  • Eat a balanced diet. Vitamin D and calcium are necessary for building strong bones. The requirement for vitamin D increases as you grow older. In the winter, when there is less sunlight, your skin produces less vitamin D. Discuss with your doctor the need to take vitamin D and calcium supplements.

  • Do not smoke.

  • Exercise. Bones need exercise to stay strong and healthy. Consult your doctor about an exercise program suitable to you.

  • While diet, exercise and vitamins are essential to good health, they may not be enough to offset the effects of estrogen decline in some women's bodies after menopause. Consequently, some people may require medications such as EVISTA to prevent or treat osteoporosis.

What Evista does

EVISTA is a Selective Estrogen Receptor Modulator or SERM. EVISTA is not a hormone, but it acts like estrogen in some parts of your body including the bones, but not like estrogen in other parts of the body. In the bones it promotes the building of new bone, either to prevent or treat osteoporosis.

When Evista should not be used

Do not take EVISTA if:

  • you have not passed menopause. EVISTA is for use only by women after menopause.

  • you are pregnant or could become pregnant. EVISTA could harm your unborn child.

  • you are nursing a baby. It is not known if EVISTA passes into breast milk or what effect it might have on the baby.

  • you have or have had blood clots in the veins that required a doctor's treatment. This may include clots in the legs, lungs or eyes. Taking EVISTA may increase the risk of getting these blood clots.

  • you are allergic to raloxifene or any of the other ingredients in EVISTA listed in the “What the important nonmedicinal ingredients are:”.

What the medicinal ingredient is

Raloxifene hydrochloride.

What the important nonmedicinal ingredients for Evista are

Anhydrous lactose, crospovidone, FD&C Blue No. 2 aluminum lake, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, polysorbate 80, povidone, macrogol 400 and titanium dioxide E171.

What dosage forms Evista comes in

Tablet 60 mg.


Warnings and Precautions

Before starting EVISTA and to get the best possible treatment, be sure to tell your doctor if you:

  • are pregnant, breast feeding, still have menstrual bleeds, or have had a menstrual bleed in the last year, as EVISTA is only for postmenopausal women.

  • have had an allergic reaction to any medicine you have taken.

  • are intolerant to lactose because EVISTA contains lactose.

  • have or ever had liver problems.

  • have or ever had blood clots in the veins. If you take warfarin (blood thinner) or other coumarin derivatives, EVISTA may not be suitable for you. EVISTA is contraindicated in women with an active or past history of blood clots in the veins. If you are taking the blood thinners for other reasons your doctor may need to check your prothrombin (blood clotting) time and adjust your medicine when you first begin taking EVISTA.

  • are currently on any other medications, prescription or non prescription.

  • have had a stroke or have a history of other significant risk factors for stroke, such as a “mini-stroke” (TIA/transient ischemic attack), or a type of irregular heartbeat (atrial fibrillation).

Being immobile for a long time can increase the risk of blood clots in the veins. EVISTA may add to this risk. If while taking EVISTA you plan to be immobile, such as staying in bed after surgery, or taking a long plane trip, you should stop taking EVISTA at least 3 days before, to reduce your risk of blood clots in the veins. When you are back on your feet, you may start taking EVISTA again (see Side Effects and What to Do About Them:).


Interactions with Evista

You should always tell your doctor about all drugs you are taking or plan to take before starting to take EVISTA.

The effect of EVISTA is significantly reduced if taken with cholestyramine (products which contain cholestyramine include Questran, Questran Light, Alti-Cholestyramine Light, Novo-Cholamine, Novo-Cholamine Light, PMS-Cholestryramine). Therefore, you should not take cholestyramine while taking EVISTA.

It is not recommended that you combine EVISTA with hormone replacement therapy (ERT or HRT) since no studies have been done to look at the effectiveness or safety of this combination.

During clinical trials, EVISTA was taken with commonly prescribed medications such as acetaminophen, digoxin, nonsteroidal anti-inflammatory drugs (NSAIDs), and oral antibiotics with no observed problems. However, because each patient is different, you should always check with your doctor before taking any other medication.


Proper Use of Evista

Usual dose

Take one EVISTA 60 mg tablet, once-a-day, any time, with or without food. EVISTA comes in a 28-day blister pack that you start as soon as you fill your prescription. Each day of the week is printed above each tablet to make it easy to check if you've taken your pill that day.

You might find it helpful to take your tablet at the same time every day so that it's simply part of your routine. The efficacy of EVISTA is dependent upon your taking it regularly. Therefore, you should keep taking EVISTA until your doctor advises you otherwise.

Overdose

If you take too much EVISTA, immediately contact your doctor or go to your nearest hospital emergency department. Show the doctor your blister pack of tablets. Do this even if there are no signs of discomfort or poisoning.

For management of a suspected drug overdose, contact your regional Poison Control Centre.

Missed dose

If you miss a day of EVISTA take one pill as soon as you remember and resume one tablet once daily. Do not take two doses at the same time.


Side Effects for Evista and What to Do About Them

During clinical trials, some women did have mild side effects however most women did not find these side effects serious enough to stop taking EVISTA. The most common side effects of EVISTA are:

  • hot flashes

  • leg cramps

Another common side effect is flu-like symptoms.

Similar to estrogen replacements, EVISTA may increase the risk of blood clots in the veins. Although this is an uncommon side effect, if you experience any of the following unusual symptoms talk to your doctor immediately:

  • redness, swelling, heat or pain in your calves and legs

  • sudden chest pain or shortness of breath

  • a sudden change in your vision

EVISTA is not associated with adverse effects on the uterus, breast, or mental function. Therefore, any unexplained uterine bleeding, breast enlargement, breast pain, change in mood or deterioration of mental function should be reported to your doctor.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Uncommon Blood clots in the veinsa    
Rare Blood clots in the lungsa    
Stroke fatalityb      
a. See “Side Effects and What to Do About Them:” for symptoms of blood clots in the veins. If you experience any of the listed symptoms talk to your doctor immediately. b. Women who have had a heart attack or are at risk for a heart attack may have an increased risk of dying from stroke when taking EVISTA.

This is not a complete list of side effects. For any unexpected effects while taking EVISTA, contact your doctor or pharmacist.


Technical Information

What Others Are Saying About evista:

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