Emend 80mg & 125mg

 
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About Emend

What Emend is used for

EMEND, in combination with 5-HT3 antagonists and dexamethasone, is indicated for the prevention of nausea and vomiting associated with your cancer chemotherapy treatment.

What Emend does

EMEND is a member of a new class of medicines called neurokinin 1 (NK1) receptor antagonists. EMEND works by blocking neurokinin, a substance in the brain that causes nausea and vomiting.

When Emend should not be used

Do not take EMEND if you are allergic to any of its ingredients.

Do not take EMEND with pimozide, terfenadine, astemizole, or cisapride. Taking EMEND with these medications could result in serious or life-threatening problems.

What the medicinal ingredient is

Aprepitant

What the important nonmedicinal ingredients for Emend are

Gelatin, hydroxypropyl cellulose, microcrystalline cellulose, sodium lauryl sulfate, sucrose and titanium dioxide. The 125 mg capsule shell also contains red ferric oxide and yellow ferric oxide.

What dosage forms Emend comes in

Each capsule contains 80 mg or 125 mg of aprepitant.


Warnings and Precautions

Serious Warnings and Precautions

Drug interactions with:

  • Medicines that are likely to be broken down mainly by the liver

  • Warfarin

  • Hormonal contraception (birth control medicines)

BEFORE you use EMEND talk to your physician or pharmacist if:

  • you have any past or present medical problems

  • you have liver problems

  • you have any allergies

  • you drive a car or operate machinery

  • you are pregnant or plan to become pregnant

  • you are breast-feeding or plan to breast-feed

Use in children

EMEND should not be given to children under 18 years of age.

Use in the elderly

No dosage adjustment is necessary.


Interactions with Emend

Tell your physician about all medicines that you are taking or plan to take, even those you can get without a prescription or herbal products.

Your physician may check that your medicines are working properly together if you are taking other medicines such as:

  • anti-anxiety drugs (such as alprazolam, midazolam)

  • birth control medicines (which may not work as well)

  • ketoconazole (an antifungal)

  • rifampin (an antibiotic)

  • paroxetine (a medicine used to treat a certain type of depression)

  • diltiazem (a medicine used to treat high blood pressure)

  • dexamethasone, methylprednisolone (steroid medicines used for a variety of conditions)

  • warfarin (a blood thinner)

  • tolbutamide (a medicine used to treat diabetes)

  • phenytoin (a medicine used to treat seizures)


Proper Use of Emend

Usual dose

Take EMEND exactly as your physician has prescribed. The recommended dose of EMEND is one 125 mg capsule by mouth 1 hour before you start your chemotherapy treatment and one 80 mg capsule each morning for the 2 days following your chemotherapy treatment.

EMEND may be taken with or without food.

Overdose

If you take more than the prescribed dosage, contact your physician immediately.

Missed dose

Try to take EMEND as prescribed. However, if you miss a dose, contact your physician for further instructions.


Side Effects for Emend and What to Do About Them

Any medicine may have unintended or undesirable effects, so-called side effects.

Like all prescription drugs, EMEND may cause side effects. The most common side effects included diarrhea, stomach pain, upset stomach, dizziness, hiccups, fatigue, constipation, headache, and loss of appetite.

Other side effects may also occur rarely, which include: anxiousness, fever with increased risk of infection, dry mouth, conjunctivitis (eye discharge and itching), excessive sweating, flushing, painful burning urination, itching, muscle cramp or pain, and taste disturbance.

The following side effects have been reported in general use with EMEND: Allergic reactions, which may be serious, and may include hives, rash and itching and cause difficulty in breathing or swallowing. If you have an allergic reaction, stop taking EMEND and call your physician right away.

Ask your physician or pharmacist for more information. Both have a more complete list of side effects. Tell your physician or pharmacist promptly about these or any other unusual symptoms.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Uncommon Allergic reactions/ Angioedema (swelling of the face, eyes, lips, tongue, throat, difficulty in breathing or swallowing)    
Stevens-Johnson syndrome (severe skin reactions, blistering)    
Urticaria (severe rash, itching, swelling of the hands and feet)    

This is not a complete list of side effects. For any unexpected effects while taking EMEND, contact your physician or pharmacist.


Technical Information