Zanaflex Medication Information:

Price Break On Zanaflex
Generic is available for less money: Generic Tizanidine

Zanaflex medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Zanaflex 2 mg
Zanaflex 4 mg

About Zanaflex

What Zanaflex is used for

Zanaflex (tizanidine hydrochloride) is a drug used to reduce the spasticity which may be caused by medical conditions such as spinal cord injury or multiple sclerosis.

What Zanaflex does

Tizanidine presumably reduces spasticity by decreasing the activity of nerves that cause muscle spasticity. The overall effect is muscle relaxation.

When Zanaflex should not be used

Do not use Zanaflex if you:

  • are allergic to it or to any of the nonmedicinal ingredients (see What the important nonmedicinal ingredients are:). Stop taking the drug and contact your doctor immediately if you experience an allergic reaction or any severe or unusual side effects.

  • are currently taking fluvoxamine or ciprofloxacin.

  • need spasticity to maintain upright posture and balance for your movements.

What the medicinal ingredient is

Tizanidine hydrochloride.

What the important nonmedicinal ingredients for Zanaflex are

Anhydrous lactose.

Other nonmedicinal ingredients include: microcrystalline cellulose, silicon dioxide colloidal, and stearic acid.

What dosage forms Zanaflex comes in

4 mg tablets.

Warnings and Precautions

BEFORE you use Zanaflex, talk to your doctor or pharmacist if any of the following conditions apply to you:

  • history of an unusual or allergic reaction to Zanaflex or to any other substances, such as foods, preservatives or dyes

  • pregnancy or breast-feeding

  • liver disease

  • kidney disease

  • low blood pressure

  • presently receiving treatment with antihypertensives (high blood pressure medicine), oral contraceptives (birth control pills), fluvoxamine, ciprofloxacin, or phenytoin.

Do not drive or operate hazardous machinery if you are unsure how this medication will affect you or if you experience drowsiness, coordination problems, or blurred vision.

It is important to tell your doctor or pharmacist about all medicines that you are taking including other medicines that a doctor has prescribed, medicines that you buy yourself without a prescription, and any herbal remedies that you are taking. While on Zanaflex, do not start taking a new medicine or herbal remedy before checking with your doctor.

Interactions with Zanaflex

Do not use Zanaflex if you are taking fluvoxamine or ciprofloxacin.

Alcohol and other central nervous system depressants (medicines causing drowsiness or decreased alertness such as antihistamines, sedatives, tranquilizers, sleeping medicines, prescription pain medicines, narcotics, anti-epileptics, other muscle relaxants, and anaesthetics) may increase the drowsiness experienced with Zanaflex.

Other drugs that may interact with Zanaflex include: acetaminophen, oral contraceptives, blood pressure lowering drugs, antiarrhythmic heart medications (e.g. amiodarone, mexiletine, propafenone), cimetidine (to reduce stomach acid), fluoroquinolone-type antibiotics (e.g. norfloxacin, moxifloxacin), and ticlopidine (to prevent blood clotting).

Proper Use of Zanaflex

Usual dose

Take Zanaflex as directed by your doctor. Do not take larger or more frequent doses than your doctor has prescribed. During the first weeks of treatment, your doctor may want to adjust your dose to meet your individual needs.

If you need to stop taking Zanaflex, follow your doctor's instruction on how to gradually reduce your dose.

Food can affect the absorption of Zanaflex in your body—so it is important to take it in the same way all the time. For example, if you normally take Zanaflex with a meal, you should take it with food each time. If you normally take Zanaflex on an empty stomach, then you should always take it before you eat.


The majority of the cases of tizanidine overdose reported in post-marketing experience involved sleepiness, very long or deep sleeplike state from which a person can be awakened only briefly by vigorous stimulation (stupor) or cannot be at all (coma), heart beat at an unusually slow rate, fall in blood pressure, and difficulty breathing.

In case of overdose, contact your doctor or nearest hospital emergency department, even though you may not feel sick.

Side Effects for Zanaflex and What to Do About Them

Zanaflex may cause dry mouth, drowsiness, weakness, fatigue, hallucinations, or dizziness in some patients.

Zanaflex may cause a decrease in your blood pressure. In some cases, decreased blood pressure may result in dizziness, lightheadedness, or fainting when a person rises suddenly from a sitting or lying position. Rising slowly may decrease the risk of these problems.

Rare cases of liver damage have been reported in patients receiving Zanaflex. Monitoring of liver function tests (ALT/AST) during treatment with Zanaflex may be required by your doctor.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Common Hallucination    
Hypotension (feeling dizzy, lightheaded, or faint)    
Uncommon Liver disorder (symptoms include nausea, vomiting, loss of appetite combined with itching, yellowing of the skin or eyes, dark urine)   a  
Allergic reactions (red and lumpy skin, rash, hives, swelling, trouble breathing)     a
Breakdown of muscle fibers [symptoms include abnormal urine color (dark, red, or cola colored), muscle tenderness, weakness of the affected muscle(s), generalized weakness or muscle stiffness or aching]    
a. If you think you have these side effects, it is important that you seek medical advice from your doctor straight away.

This is not a complete list of side effects. For any unexpected effects while taking Zanaflex, contact your doctor or pharmacist.


Technical Information