Cafergot

Cafergot Medication Information:

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Cafergot 1 mg
Cafergot Suppositories 2 mg

About Cafergot

What Cafergot is used for

CAFERGOT tablets are intended to relieve your migraine headache and other associated symptoms of a migraine attack.

  • Use CAFERGOT tablets only to treat an actual migraine attack.

  • CAFERGOT tablets should not be used continuously to prevent or reduce the number of attacks you experience.

  • CAFERGOT should not be used to relieve pain other than that associated with migraine headache.

What Cafergot does

Migraine headache is believed to be caused by a widening of the blood vessels in the head. CAFERGOT narrows the vessels and relieves the pain and other symptoms of migraine attacks.

Caffeine may increase the absorption of ergotamine from the gastrointestinal tract and may help to relieve migraine.

When Cafergot should not be used

Do not take CAFERGOT if you:

  • Are allergic to the active ingredients ergotamine, caffeine, to other ergot alkaloids, or to any other ingredient in the CAFERGOT tablets (see What the nonmedicinal ingredients are:).

  • Are being treated for an infection with so-called macrolide antibiotics for example: erythromycin, troleandomycin, clarithromycin.

  • Are being treated for HIV/AIDS with medicines like ritonavir, nelfinavir, indinavir or delavirdine.

  • Are being treated for fungal infection with medicines like ketoconazole, itraconazole or voriconazole.

  • Are being treated with other agents which constrict blood vessels and are used to treat migraine such as 5-HT1 receptor-agonists including triptans or as preparation containing ergot alkaloids such as dihydroergotamine.

  • Have conditions which predispose you to an excessive contraction of blood vessels (vasospastic reactions) such as: heart disease (particularly angina pectoris), vascular disease, inadequately controlled hypertension (high blood pressure), septic conditions (a serious complication of an infection) and shock.

  • Have a severe liver disease.

  • Have a severe kidney disease.

  • Are pregnant, think you may be, are trying to become pregnant, or are using inadequate contraception (see Pregnant women:).

  • If you are breast-feeding (see Breast-feeding mothers:).

CAFERGOT should not be used for the treatment of other types of headaches that are different from migraine attacks.

What the medicinal ingredients for Cafergot are

Ergotamine tartrate and caffeine.

What the nonmedicinal ingredients for Cafergot are

Each tablet also contains the following inactive ingredients: cellulose microcrystalline, iron oxide pigment yellow, magnesium stearate, maize starch, talc and tartaric acid.

What dosage forms Cafergot comes in

CAFERGOT is available in tablets containing 1 mg ergotamine tartrate USP and 100 mg caffeine USP.


Warnings and Precautions

Serious Warnings and Precautions

Some medicines used to treat infection and HIV/AIDS may cause an increase in the amount of CAFERGOT in the blood, increasing the risk of serious side effects. You should not take CAFERGOT if you are treated with any of these medicines (see When it should not be used:).

Take special care with CAFERGOT if you:

  • Have pleural fibrosis (thickening of the serous membranes that covers the lungs and lines the chest cavity).

  • Have retroperitoneal fibrosis (thickening of the serous membranes that covers the gut system and lines the abdominal wall).

  • Have mild to moderate impairment of liver function.

  • Are taking selective serotonin reuptake inhibitors (SSRIs) such as Prozac (fluoxetine), Paxil (paroxetine), and Zoloft (sertraline), or serotonin norepinephrine reuptake inhibitors (SNRIs) such as Effexor XR (venlafaxine), two types of drugs for depression or other disorders.

If any of these apply to you, tell your doctor before you take CAFERGOT.

CAFERGOT and children

There is no experience with the use of CAFERGOT in children below 6 years of age.

Pregnant women

If you are pregnant or think you may be, tell your doctor. CAFERGOT must not be given to pregnant women.

Women who might get pregnant are advised to use effective contraception during treatment with CAFERGOT.

Breast-feeding mothers

If you are breast-feeding, tell your doctor. Do not breast-feed during the treatment with CAFERGOT. The active ingredient of CAFERGOT may pass into breast milk and may affect your baby.

Driving and using machines

Do not drive or use machines if you experience side effects such as dizziness or vertigo.


Interactions with Cafergot

Tell you doctor or pharmacist if you are taking or have recently taken any other medicines. Remember also those not prescribed by a doctor.

Some medicines may increase the risk of serious side effects if taken concurrently with CAFERGOT.

Do not take CAFERGOT if you:

  • Are being treated with any of the following medicines: erythromycin, troleandomycin, clarithromycin, ritonavir, nelfinavir, indinavir, delavirdine, ketoconazole, itraconazole or voriconazole.

  • If you are being treated with other agents which constrict blood vessels and are used to treat migraine such as 5-HT1 receptor-agonists for example triptans or as preparation containing ergot alkaloids such as dihydroergotamine.

In addition, nicotine (e.g., smoking), β-blockers (such as propranolol, a medicine used to prevent migraine and also to treat high blood pressure), estrogen-based contraceptives and grapefruit juice may cause interactions.


Proper Use of Cafergot

Follow your doctor’s instructions carefully. Do not exceed the recommended dosage.

Usual dose

Your doctor will tell you exactly how to take CAFERGOT.

Adults

CAFERGOT should only be used to treat acute migraine attacks and it must not be used to prevent them.

At the first sign of a migraine attack, swallow with some water 2 tablets of CAFERGOT. This dose is usually enough to stop an attack. If the migraine attack does not go away, you can take 1 additional tablet every half hour at to a maximum of 6 tablets in one day.

Depending on how you respond to the treatment, your doctor may suggest a higher or lower dose for the next attack.

Do not take more than 6 tablets in one day.

Do not take more than 10 tablets in one week.

Do not use at the same time other ergot alkaloids or 5-HT1 receptor agonists for treating your migraine (see When it should not be used:).

If your migraine does not improve in spite of the recommended use of CAFERGOT, contact your doctor or the emergency department of your local hospital.

Children (from 6 to 12 years)

The initial dose is 1 CAFERGOT tablet; additional doses of 1 tablet may be given twice only, if required, in the course of an attack. Keep a record of how many tablets your child has taken each day and during the week.

The maximum dose in one day for children for 6 to 12 years is 3 tablets.

The maximum dose in one week for children for 6 to 12 years is 5 tablets.

How long to take CAFERGOT?

Do not use CAFERGOT more often than instructed since otherwise you may have increased risk of serious side effects such as ergotism (severe constriction of blood vessels), fibrotic changes (thickening of the chest and abdominal linings) (see Side Effects and What to Do About Them:).

Overdose

If you accidentally take too much CAFERGOT, talk immediately to a doctor or pharmacist or go to the nearest hospital emergency department and bring your prescription, remaining tablets, or container with you.


 

Technical Information