Combigan 0.2%/0.5%

Combigan 0.2%/0.5% Image

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Best Value On Brand Combigan 0.2%/0.5%
Price: $13.04 per ml!
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Combigan 0.2%/0.5% Prescription Required
10 mL for $130.41 ($13.04 per ml)
Combigan from online pharmacy: Canada
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Order Combigan 0.2%/0.5% today and have it delivered quickly and discreetly to your home. For many medication products on our website, a prescription is often required. In other cases, no prescription is required for OTC (over the counter) drugs. If you desire to save on drugs, one alternative to your local store is to buy from an online pharmacy like The Drug Company. The Drug Company offers medications from a wide selection of licensed pharmacies, including a Canadian pharmacy. Many people trust prescription medications from Canada, as well as all of the pharmacies in our network.

About Combigan

What Combigan is used for

COMBIGAN is used for:

  • Reducing pressure in the eye (intraocular pressure, or IOP). This high pressure can lead to a disease called glaucoma. If the high pressure is not reduced, it could eventually damage your sight.

What Combigan does

The eye contains a clear, watery liquid. Liquid is constantly being drained out of the eye and new liquid is made to replace this. If the liquid cannot drain out quickly enough, the pressure inside the eye builds up. COMBIGAN is a preserved eye drop solution that reduces the amount of fluid flowing into the eye and increases the amount of fluid flowing out of the eye.

Remember: This medication is prescribed for the particular condition you have. Do not give this medication to other persons or use it for any other condition.

When Combigan should not be used

Do not use COMBIGAN if you:

  • Are allergic to any of its components (See What the important nonmedicinal ingredients are:.)

  • Have asthma or have ever had asthma

  • Have chronic obstructive lung disease

  • Have certain heart diseases or conditions

  • Have diabetes or are subject to low blood sugar levels without apparent cause

  • Are receiving monoamine oxidase (MAO) inhibitor therapy

  • Are breast-feeding or pregnant

What the medicinal ingredients for Combigan are

This product contains two medicinal ingredients. It is a combination of brimonidine tartrate 0.2% and timolol 0.5% as timolol maleate.

What the important nonmedicinal ingredients for Combigan are

Benzalkonium chloride.

Other nonmedicinal ingredients in the product include: sodium phosphate, monobasic monohydrate; sodium phosphate, dibasic heptahydrate; purified water. Hydrochloric acid and/or sodium hydroxide may be added to adjust pH.

What dosage forms Combigan comes in

COMBIGAN is supplied in white, opaque plastic dropper bottles containing: 2.5 mL, 5 mL or 10 mL.

Warnings and Precautions

Severe respiratory reactions and cardiac reactions, including death due to bronchospasm in patients with asthma, and rarely death in association with cardiac failure, have been reported following systemic or ophthalmic administration of timolol.

BEFORE you use COMBIGAN talk to your doctor or pharmacist if:

  • You have or have had kidney or liver problems in the past.

  • You have had thyroid problems in the past.

  • You have had eye problems in the past, such as choroidal detachment.

  • You have had problems or develop problems with blood flow to the brain

  • You have any medical problems now or have had any in the past, especially asthma and other lung problems or heart problems.

  • You have diabetes or are subject to low blood sugar levels without apparent cause.

  • You are pregnant or intend to become pregnant.

  • You are breast-feeding or intend to breast-feed. Timolol has been detected in human breast milk. Discuss with your doctor.

  • You are planning to have major surgery.

  • If you have ocular surgery or develop an intercurrent ocular condition (e.g., trauma or infection). Immediately seek your physician’s advice concerning the continued use of the present multidose container.

  • You have any allergies to this drug, or to similar drugs (ask your doctor) or to COMBIGAN’s ingredients or components of its container.

  • You are taking or intend to take other prescription or non-prescription drugs. This is particularly important if you are taking medicine to lower blood pressure or to treat heart disease.

  • You wear contact lenses. The preservative in COMBIGAN (benzalkonium chloride) may be absorbed by soft (hydrophilic) contact lenses. Lenses should be removed prior to application of COMBIGAN and kept out for 15 minutes after use.

  • You drive or operate heavy equipment. This medication may potentially cause fatigue and/or drowsiness in some patients.

Interactions with Combigan

Drugs that may interact with COMBIGAN include:

Heart or blood pressure medications, such as beta-blockers, calcium channel blockers, catecholamine depleting drugs such as reserpine, epinephrine, tricyclic depressants, quinidine, clonidine, alcohol, and other central nervous system depressants.

Proper Use of Combigan

Usual dose

The usual dose is one drop in the affected eye(s) in the morning and in the evening.

If you are using COMBIGAN with another eyedrop, the drops should be instilled at least 10 minutes apart. Do not allow the tip of the dropper to touch your eye or any of the areas right around your eye. Touching other areas may contaminate the solution, and you may develop a serious eye infection.


Contact a poison control centre as soon as possible. Symptoms of overdose include dizziness, headache, shortness of breath, slow heart beat, difficulty breathing, and cardiac arrest. These symptoms may occur if the overdose is to the eyes, or if the contents of the bottle are accidentally swallowed.

Missed dose

If a dose of this medication has been missed, it should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and go back to the regular dosing schedule. Do not double doses.

Side Effects for Combigan and What to Do About Them

Some common side effects which may occur include dry mouth, burning/stinging eye(s), itchy eye(s), dry eyes, eye pain, swollen/inflamed/bloodshot eyes, blurred vision, and headache. If these persist or cause you concern, consult your doctor.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Uncommon Severe allergic reaction and symptoms, such as swelling of the mouth and throat, difficulty in breathing, hives, severe itching and rash    
Slow heartbeat    
Heart effects such as irregular heartbeat, heart block, and low blood pressure    

This is not a complete list of side effects. For any unexpected effects while taking COMBIGAN, contact your doctor or pharmacist.

Technical Information