Topamax

Topamax Medication Information:

Price Break On Topamax
Generic is available for less money: Generic Topiramate

Topamax medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Topamax 25 mg
Topamax 50 mg
Topamax 100 mg
Topamax 200 mg

Topamax General Information:

Topamax (or Topriamate) is a prescription-based monosaccharide anticonvulsant drug that has two FDA-approved uses. It can be used by adults alone or in concert with other drugs to treat symptoms of epilepsy. It can also be used by adults to treat migraine headaches. Children can also use Topamax to treat symptoms of Lennox-Gastaut syndrome, a debilitating type of epilepsy that causes seizures and severe behavioral problems.

In addition to its FDA-approved uses, Topamax has also been used on an experimental basis to treat other disorders. Physiatrists use Topamax to treat bi-polar disorder, bulimia nervosa and obsessive-compulsive disorder. Other people use it as a weight loss supplement. Topamax has also been used on an experimental basis to treat post-traumatic stress syndrome, cocaine dependency and alcoholism.

How does Topamax work & what does it do?

Topamax's main function is to slow down overactive nerve cells that send excessive pain, sensory or movement signals to the brain. When taken properly over time, Topamax is able to do this because it prevents a nerve cell's AMPA receptors from overfiring. Topamax is able to prevent AMPA receptors from overfiring because it modulates the rate at which the AMPa receptors sends messages to the brain that cause patients to feel pain, see images or move.

When/How is Topamax taken/used/applied?

How is Topamax taken?Topamax is taken orally with or without food. Topamax can be taken orally either by swallowing capsules or by sprinkling the drug onto a small amount of food. If patients decide to take the capsules, they should not break the tablets into pieces. In addition, the drug should be swallowed immediately to allow the drug to break down more quickly in the body.

When is Topamax taken? How much is taken at a time? How much can one consume in a day?Topamax is usually taken in two (or three) doses--once in the morning (perhaps once in the afternoon) and once at night--in equal amounts. The amount of Topamax taken each time depends on the malady that is being treated. For example, patients who take Topamax for migraine headaches usually take between 25-100 mg a day.

On the other hand, adults who take Topamax for epilepsy usually start with a dose between 25-50 mg per day before gradually increasing the dose to somewhere between 100-200 mg per dose. This dosage is adjusted based on factors that include the other types of drugs being taken to treat epilepsy and the severity of the symptoms.

Furthermore, children between the ages of 2-16 are introduced to the drug slowly. At first, children are given a dose that is roughly equal to 1.5 mg per 1 kg of bodyweight. Afterwards, their dose is adjusted until it is roughly 5-9 mg per 1 kg of bodyweight.

What are the common side effects that occur from taking Topamax?

Taking Topamax can lead to several common side effects. Among them are an inability to taste sweet foods, back pain, chest pain, constipation and diarrhoea. Other common side effects include headaches, drowsiness, an increase in the risk of kidney stones, heartburn, nausea, tremors, and increased sweat production.

Other brand names for Topamax:

Topamax has one generic brand name: Topriamate.

Safety Information:

There are many people who should not take Topamax. This group includes people who are allergic to monosaccharides (like those found in artificial sweeteners), people who are allergic to artificial dyes, women who are taking birth control pills, women who are pregnant and people with decreased liver function.

In addition, people who have had a history of kidney stones, a history of extensive caffeine use or a history of trouble maintaing a constant body temperature should consult their doctors before using Topamax. These people are at a greater risk for developing side effects and should therefore ask their doctors if Topamax is right for them.

Dosage:

Topamax comes in tablets and easy-to-open capsules. Here is a list of the known dosages that the capsules and pills come in.

Break open capsules:

  • break open capsule (15 mg).
  • break open capsule (25 mg).

Tablets:

  • 25 mg tablet.
  • 100 mg tablet.
  • 200 mg tablet.

Visual Description:

Break open capsules:
Each break-open capsule features a white and clear gelatine capsule that has white off-centre spheres on their surfaces. The capsule is also marked on both sides. One side clearly states the "top" of the capsule while the other side describes the dosage. Inside the capsule, you will find tiny Topiramate-coated beads with the proper dose of the drug.

Tablets:The 25 mg tablet is white, round and coated with carnauba wax. It is also embossed with the dosage ("25") on one side and "top" on the other.
The 100 mg tablet is yellow, round and coated with carnauba wax. It is also embossed with the dosage ("100") on one side and "top" on the other.
The 200 mg tablet is salmon-pink colored. It is also round, coated with carnauba wax and embossed with the dosage ("200") on one side and "top" on the other.

About Topamax

What Topamax is used for

TOPAMAX has been prescribed to you/your child to control epilepsy.

  • TOPAMAX may also be prescribed to you to prevent your migraine headaches if you are an adult patient (over 18 years of age) with 4 or more attacks per month and are not responding to acute treatment.

What Topamax does

TOPAMAX affects chemicals in the brain that are involved in sending signals to the nerves. TOPAMAX belongs to a group of medicines used to treat epilepsy.

When Topamax should not be used

You/your child should not use TOPAMAX if you are allergic to any of the ingredients in the product. Contact your doctor immediately if you experience an allergic reaction (e.g. skin rash, hives) or any severe or unusual side effects.

TOPAMAX should not be used for:

  • the prevention of other types of headaches that are different from migraine attacks.

  • the acute treatment of migraine headache.

What the medicinal ingredient is:

Topiramate.

What the nonmedicinal ingredients for Topamax are:

Tablets:

Carnauba wax, hypromellose (hydroxypropyl methylcellulose), lactose monohydrate, magnesium stearate, pregelatinized starch, microcrystalline cellulose, polyethylene glycol, polysorbate 80, purified water, sodium starch glycolate, titanium dioxide, and may contain synthetic iron oxide.

Sprinkle Capsules:

Black pharmaceutical ink, cellulose acetate, gelatin, povidone, sorbitan monolaurate, sodium lauryl sulfate, sugar spheres (sucrose and starch) and titanium dioxide.

What dosage forms Topamax comes in

Tablets:

25 mg, 100 mg, 200 mg.

Sprinkle Capsules:

15 mg, 25 mg.


Warnings and Precautions

BEFORE you use TOPAMAX talk to your doctor or pharmacist if:

  • you drive a vehicle, use machines, perform hazardous tasks during your work or do anything else that could be dangerous if you are not alert.

  • you/your child have or have had kidney stones or kidney disease. Your doctor may want you to increase the amount of fluids you/your child drink(s) while taking this medicine.

  • you/your child have or have had liver disease.

  • any medical problems and any allergies you/your child have or have had in the past.

  • you are pregnant, or you are planning to become pregnant.

    If you become pregnant while taking TOPAMAX, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. You can enroll in this registry by calling 1-888-233-2334. The purpose of this registry is to collect information about the safety of antiepileptic medicine during pregnancy. Information on the registry can also be found at the website http://www.aedpregnancyregistry.org/.

  • you are breast-feeding (nursing).

  • you/your child are/is taking medicines that slow down the nervous system (CNS depressants).

  • you/your child are taking oral contraceptives and TOPAMAX Tablets or Sprinkle Capsules, and tell your doctor about any changes in your bleeding patterns (breakthrough bleeding/spotting).

  • you are taking a ketogenic diet (a diet high in fat and low in protein and sugar).

  • you consume alcohol regularly.

  • You/your child have a growth problem.

Other Precautions

TOPAMAX may cause some people to be less alert than normal. Make sure you know how you/your child are/is affected by this medication before you drive, use machines, or do anything else that could be dangerous if you are not alert.

TOPAMAX may reduce the efficacy of oral contraceptives even in the absence of breakthrough bleeding. Therefore, oral contraceptives containing not less than 30 µg of estrogen should be used.

A very small number of people may have thoughts of suicide.

Rarely, blood tests have shown a slight increase in acidity. In many cases, there are no symptoms from this increased acidity but some people may experience symptoms such as rapid breathing, persistent lack of energy and loss of appetite. Some people may experience more serious symptoms such as heart problems, confused thinking or reduced consciousness.

Do not discontinue this medication without talking to your doctor first.


Interactions with Topamax:

Tell your doctor about all medications (prescription and non-prescription) and dietary supplements you/your child are/is using. It is especially important that your doctor know if you/your child are/is taking digoxin, oral contraceptives, glyburide, lithium, risperidone, diltiazem, or any other antiepileptic drugs, such as phenytoin, valproate or carbamazepine.


Proper Use of Topamax

TOPAMAX is usually taken twice a day; however, your doctor may tell you to take it once a day or at a higher or lower dose.

Never stop taking, increase or decrease the amount of TOPAMAX you are taking unless your doctor tells you to.

Swallow the Tablets or the Sprinkle Capsules and take with plenty of water. You/your child can take the Tablets or the Sprinkle Capsules with or without food. Do not break or crush your tablets. You may swallow the Sprinkle Capsules whole with water or administer them by carefully opening the capsule and sprinkling the entire contents on a small amount (teaspoon) of soft food. This drug/food mixture should be swallowed immediately and not chewed. It should not be stored for future use.

Always check that you have enough Tablets or Sprinkle Capsules and do not run out. Do not suddenly stop taking this medicine without first checking with your doctor.

Epilepsy

It is important that you take TOPAMAX exactly as your doctor has instructed. Your doctor will start with a low dose and slowly increase the dose to the lowest amount needed to control your/your child’s epilepsy.

Usual dose

TOPAMAX taken alone: The usual maintenance dose in adults and children (6 years of age and older) is between 100 mg/day and 400 mg/day. TOPAMAX is usually taken twice a day.

TOPAMAX taken in combination with other antiepileptic drugs: The usual adult maintenance dose is 200 mg to 400 mg per day.

In children, dosing is based on weight and the dose is approximately 5 to 9 mg/kg/day.

Migraine

It is important that you follow your doctor’s instructions carefully to help reduce the chances of getting a migraine headache. Your doctor will start treatment with a dose of 25 mg to be taken at night. Your doctor will then increase your dose to the lowest amount needed to prevent migraine headaches.

Usual dose

The usual adult dose is 100 mg per day. TOPAMAX is taken twice a day (50 mg in the morning and 50 mg at night). Your doctor may tell you to use a lower or higher dose.

Remember: This medicine has been prescribed for you/your child. Do not give it to anybody else.

Topamax Facts

Topamax is the first daily medication prescribed to prevent migraine headaches.

The FDA approved Topamax as a treatment for adults with seizures on December 24, 1996.

In clinical trials, Topamax showed potential for weight reduction and is sometimes prescribed "off label" for that purpose.

Topamax is manufactured and marketed by Ortho-McNeil Pharmaceuticals, headquartered in Raritan, New Jersey.

 

Technical Information