Amaryl Medication Information:

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Generic is available for less money: Generic Glimepiride

Amaryl medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Amaryl 1 mg
Amaryl 2 mg
Amaryl 3 mg
Amaryl 4 mg

About Amaryl

What Amaryl is used for

Amaryl is a medication that is used to treat type 2 diabetes. The chemical name for Amaryl is “glimepiride”; it belongs to a class of drugs called sulfonylureas.

To properly control your diabetes, it is essential that you follow the diet, exercise and weight loss program recommended by your doctor. It is also important that you test your blood for sugar according to your doctor's recommendations.

What Amaryl does

Amaryl is indicated as an addition to proper dietary management, exercise and weight reduction to lower the blood glucose in patients with type 2 diabetes whose high blood sugar levels cannot be controlled by diet and exercise alone.

Amaryl may be used in combination with metformin when diet and exercise, and Amaryl or metformin alone do not result in adequate control of blood sugar levels.

Amaryl is also indicated for use in combination with insulin to lower blood glucose in patients with type 2 diabetes whose high blood sugar levels cannot be controlled by diet and exercise in conjunction with an oral hypoglycemic (a drug used to lower blood sugar levels) agent alone.

When Amaryl should not be used

Amaryl should not be used:

  • If you have Type 1 diabetes.

  • If you have known hypersensitivity or allergy to any sulfonylurea or sulfonamides or any other component of the formulation. See “What the important nonmedicinal ingredients are:”.

  • If you have diabetic ketoacidosis (an emergency condition with high blood glucose levels, a lack of insulin and an accumulation of ketones (chemicals) in the blood and urine), with or without coma. This condition should be treated with insulin.

  • If you are pregnant or breast-feeding.

What the medicinal ingredient is

The medicinal ingredient for Amaryl is “glimepiride”.

What the important nonmedicinal ingredients for Amaryl are

Amaryl tablets contain the following nonmedicinal ingredients: lactose, magnesium stearate, microcrystalline cellulose, povidone, and sodium starch glycolate. In addition: Amaryl 1 mg tablets contain Ferric Oxide, Amaryl 2 mg tablets contain Ferric Oxide and FD&C Blue #2 Aluminum Lake, and Amaryl 4 mg tablets contain FD&C Blue #2 Aluminum Lake.

What dosage forms Amaryl comes in

Amaryl is formulated into tablets of 1 mg, 2 mg, and 4 mg strengths for oral administration.

Warnings and Precautions

BEFORE you use Amaryl talk to your doctor or pharmacist if you have kidney, liver, heart or a blood disease called G6PD-deficiency anemia.

  • Do not take this medicine if you have had an allergic reaction to Amaryl or other sulfonylurea drugs or sulfonamides.

  • This medicine has been prescribed for you alone because of your medical condition. This or any other prescription medicine should be used only by the person for whom it was prescribed. It should not be shared.

  • Wear a medical identification (I.D.) bracelet or neck chain at all times. Also, carry and I.D. card in your wallet or purse that says that you have diabetes and a list of your medicines.

Low blood sugar (hypoglycemia)

  • If your blood sugar gets too low, you may feel shaky, weak, drowsy, confused, or very hungry. You may sweat or have blurred vision, a fast heartbeat, trouble concentrating, or a headache that doesn't go away. Signs of severe hypoglycemia can include disorientation, loss of consciousness, and seizures.

  • You may have low blood sugar while you are taking Amaryl, especially if you miss a meal, exercise for a long time, drink alcohol or use another antidiabetic medication or other drugs which can cause low blood sugar when taken with Amaryl (for examples of such drugs please see Interactions with This Medication: below).

    Make sure you know what to do if your blood sugar gets too low (ask your doctor, pharmacist or diabetes educator). Teach your friends, co-workers, or family members what they can do to help you if you have low blood sugar.

Pregnancy and breastfeeding

Amaryl should not be used during pregnancy or if you are breastfeeding. Make sure your doctor knows if you are breastfeeding, pregnant, or think you might be pregnant. Your doctor may want you to use insulin during this time.

Driving and Operating Machinery

Alertness and reactions may be impaired due to low or high blood sugar (hypo- or hyperglycemia), especially when beginning or after changing treatment or when Amaryl is not taken regularly. This may affect your ability to drive or to operate machinery.

Interactions with Amaryl

Drugs and foods to avoid

Ask your doctor or pharmacist before taking any other medicine, including over-the-counter products.

  • Avoid drinking alcohol while you are taking this medicine.

  • There are various drugs that can interact with Amaryl and cause hypoglycemia, which can be severe. Some of these drugs are acetylsalicylic acid such as Aspirin, “sulfa” drugs (e.g. sulphonamides), warfarin, non-steroidal anti-inflammatory drugs (NSAID), some antibiotics (e.g. clarithromycin, tetracycline) and beta-blockers.

  • Some medicines can make it harder for you to control your diabetes. These include diuretics (water pills), corticosteroids (such as prednisone), ACE inhibitors (a drug used to treat high blood pressure (hypertension)), birth control pills, and some kinds of cold and allergy drugs.

  • Make sure your doctor and pharmacist know if you are taking these or any other medicines.

Proper Use of Amaryl

Usual dose

Amaryl is usually taken once daily, with breakfast or the first main meal of the day. Amaryl tablets must be swallowed without chewing. Your doctor will prescribe for you how much to take and how often. It is important that you follow your doctor's instructions carefully.

Missed dose

Take the missed dose as soon as possible, unless it is almost time for your next dose.

Do not take two doses at the same time.

Side Effects for Amaryl and What to Do About Them

Side effects for Amaryl

As with any type of medication, Amaryl is associated with some side effects. It may, however, affect different people in different ways. Just because side effects have occurred in other people does not mean you will get them.

If you have problems with these side effects, talk with your doctor or pharmacist:

  • Mild nausea or vomiting.

  • Dizziness.

  • Low blood sugar (hypoglycemia), see Low blood sugar (hypoglycemia): above.

  • This medicine may make your skin sensitive to sunlight and could cause a rash or sunburn. Use a sunscreen when outdoors. Avoid using sunlamps or tanning beds.

Call your doctor right away if you have any of these side effects:

  • Unexplained fever, chills or sore throat.

  • Unusual bleeding or bruising.

  • Yellowing of skin or eyes, dark-colored urine or light-colored bowel movements.

  • Skin rash or hives.

  • Oedema, swelling of the legs or unexpected weight gain.

This is not a complete list of side effects. For any unexpected effects while taking Amaryl, contact your doctor or pharmacist.


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