Wellbutrin XL

Wellbutrin XL Medication Information:

Price Break On Wellbutrin XL
Generic is available for less money: Generic Bupropion SR

Wellbutrin XL medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Wellbutrin XL 150 mg
Wellbutrin XL 300 mg

What is Wellbutrin XL?

Wellbutrin XL is a drug prescribed to help relieve major depression.

How does Wellbutrin XL work?

Although the exact mechanism is unknown, it is believed that the active ingredient in Wellbutrin XL, buproprion, inhibits the reuptake of norepinephrine and dopamine inside the brain, thus alleviating symptoms of major depression. Major depression is categorized as a disorder where one has symptoms including a very depressed mood for a period of two weeks or more and a lack of interest in normal activities. Other symptoms which can be seen in major depression are changes in sleep and appetite patterns, decreased or abnormal energy levels, intense emotional feelings, and suicidal thoughts and behaviors.

When and how is Wellbutrin XL taken?

Wellbutrin XL is to be taken with or without food. It is only to be taken as prescribed and never in larger or smaller doses. The tablets are never to be crushed, chewed, split, or otherwise broken apart. They are to be swallowed whole, as this is the mechanism for which the medication is time released inside the body. Wellbutrin XL should never be stopped immediately unless directed by a physician or unless an allergic reaction occurs. The medication should be taken either in the morning or the evening, but always at the same time every day and if a dose is missed, it should not be doubled. The patient should wait until time for the next dose.

What are the side effects of Wellbutrin XL?

The most common side effects people may experience while taking Wellbutrin XL are constipation, dizziness, drowsiness, and dry mouth. Also common are flushed face, flatulence, headache, increase in sweating, increase in urination. Other common side effects are loss of appetite, nausea, nervousness, restlessness, ringing in the ears, changes in taste, stomach pain, changes in sleep, and weight changes.

The following is a list of severe side effects and if any of these are experienced while taking Wellbutrin XL, the medication should be stopped immediately and the patient should seek medical attention. These include:

  • severe allergic reactions,
  • chest pain,
  • confusion,
  • dark urine,
  • delusions,
  • fainting,
  • irregular heartbeat,
  • fever,
  • chills,
  • sore throat,
  • hallucinations,
  • hearing problems,
  • menstrual changes,
  • worsening mood changes,
  • seizures,
  • severe headache,
  • muscle pain,
  • shortness of breath,
  • tremor,
  • vision changes,
  • yellowing of the skin or eyes,
  • or attempted suicide.

Other brand names for Wellbutrin XL?

The active ingredient, buproprion, is marketed in several other brand names such as:

  • Aplenzin
  • Budeprion SR
  • Budeprion XL
  • Wellbutrin
  • Wellbutrin SR
  • Zyban
  • Zyban Advantage Pack

Safety Information:

Patients who have taken a monoamine oxidase inhibitor in the past 14 days should not take Wellbutrin XL due to health risks from drug interactions. Also, anyone who presently has an eating disorder such as anorexia nervosa or bulimia, or has had an eating disorder in the past should not take this medication. Anyone with any form of seizure disorder or anyone who has had seizures in the past are asked to avoid taking the medication due to potential seizure risks. Patients currently taking Zyban or another buproprion containing medication should not take Wellbutrin XL in order to avoid a potential drug overdose. Also, patients who have recently stopped consuming alcohol or taking sedatives should not take this medication and should inform their physician.


  • Wellbutrin XL oral tablet in 150mg strength
  • Wellbutrin XL oral tablet in 300mg strength

What is the visual description for Wellbutrin XL?

Wellbutrin XL is produced as a creamy-white which is made to be ingested and time-released in the gastrointestinal tract. One side of this tablet is stamped with edible black ink, while the other side is smooth.

About Wellbutrin XL

What Wellbutrin XL is used for

WELLBUTRIN XL has been prescribed to you by your doctor to:

  • relieve your symptoms of depression (feeling sad, a change in appetite or weight, difficulty concentrating or sleeping, feeling tired, headaches, unexplained aches and pain) OR

  • prevent autumn-winter seasonal depression in patients with a history of seasonal depression

What Wellbutrin XL does

WELLBUTRIN XL is one of a group of drugs called antidepressants. WELLBUTRIN XL is thought to block reuptake of chemicals in the brain called noradrenaline and dopamine, which are linked with depression.

When Wellbutrin XL should not be used

Do not take WELLBUTRIN XL if you

  • know that you are allergic to WELLBUTRIN SR, bupropion, or any of the other ingredients in WELLBUTRIN XL tablets.

  • are taking any other medicines which contain bupropion such as WELLBUTRIN SR or ZYBAN.

  • have been diagnosed with epilepsy or have a history of seizures.

  • have or have had an eating disorder, for example binge eating (bulimia) or anorexia.

  • are usually a heavy drinker who has just stopped or are about to stop drinking.

  • are taking Monoamine oxidase (MAO) inhibitor antidepressants (e.g. phenelzine sulphate, moclobemide).

  • are taking the antipsychotic thioridazine.

  • have liver or kidney problems.

  • are pregnant or trying to become pregnant, or if you think that you might be pregnant.

  • are breast-feeding.

What the medicinal ingredient is

Bupropion hydrochloride.

What the important nonmedicinal ingredients for Wellbutrin XL are

Denatured ethyl alcohol, ethylcellulose, glyceryl behenate, isopropyl alcohol, methylacrylic acid co-polymer dispersion, N-butyl alcohol, polyethylene glycol, polyvinyl alcohol, povidone, propylene glycol, shellac glaze, silicon dioxide, triethyl citrate, titanium dioxide, red and blue FDC dyes (150 mg) iron oxide black (300 mg).

What dosage forms Wellbutrin XL comes in

150 mg and 300 mg once daily tablets.

Warnings and Precautions

WELLBUTRIN XL is a Once Daily medication and should not be confused with other bupropion formulations.

During treatment with these types of medication it is important that you and your doctor have good ongoing communication about how you are feeling.

WELLBUTRIN XL is not for use in children under 18 years of age.

New or Worsened Emotional or Behavioural Problems

Particularly in the first few weeks or when doses are adjusted, a small number of patients taking drugs of this type may feel worse instead of better; for example, they may experience unusual feelings of agitation, hostility or anxiety, or have impulsive or disturbing thoughts such as thoughts of self-harm, or harm to others. Should this happen to you, or to those in your care if you are a caregiver or guardian, consult your doctor immediately. Close observation by a doctor is necessary in this situation.

Important Warning About the Risk of Seizures

The overall incidence of seizure with WELLBUTRIN XL in clinical trials at doses up to 450 mg/day was approximately 0.1%.

BEFORE you use WELLBUTRIN XL tell your doctor or pharmacist if you

  • have ever had any fits or seizures in the past.

  • take other medications that may increase your chance of a seizure, including drugs for depression and some antibiotics.

  • are taking any prescription or over-the-counter medications, or are planning on taking any prescription or over-the-counter medications during your therapy.

  • have, or have had an eating disorder, for example binge eating (bulimia) or anorexia nervosa.

  • have liver problems.

  • have kidney problems.

  • take more than the recommended amount of WELLBUTRIN XL tablets. WELLBUTRIN XL tablets should NOT be used if you are taking the smoking cessation aid ZYBAN or any other medications containing bupropion hydrochloride such as WELLBUTRIN SR.

  • have diabetes which is treated with insulin or other medications.

  • have use over-the-counter diet aids.

  • have had a serious head injury.

  • drink alcohol. It is best not to drink alcohol at all or to drink very little while taking WELLBUTRIN XL. If you drink a lot of alcohol and suddenly stop, you may increase your chance of having a seizure. Be sure to discuss your use of alcohol with your doctor before you begin taking WELLBUTRIN XL.

  • are pregnant, or thinking about becoming pregnant, or are breast-feeding.

Driving Vehicles or Using Machinery

WELLBUTRIN XL may impair your ability to perform tasks requiring judgement or motor and cognitive skills. Until you are reasonably certain that WELLBUTRIN XL does not adversely affect your performance you should refrain from driving an automobile or operating hazardous machinery.

Effects on Pregnancy and Newborns

Post-marketing reports indicate that some newborns whose mother took an SSRI (Selective Serotonin Reuptake Inhibitor) or other newer antidepressant, such as WELLBUTRIN XL, during pregnancy have developed complications at birth requiring prolonged hospitalization, breathing support and tube feeding. Reported symptoms include: feeding and/or breathing difficulties, seizures, tense or overly relaxed muscles, jitteriness and constant crying.

In most cases, the newer antidepressant was taken during the third trimester of pregnancy. These symptoms are consistent with either a direct adverse effect of the antidepressant on the baby, or possibly a discontinuation syndrome caused by sudden withdrawal from the drug. These symptoms normally resolve over time. However, if your baby experiences any of these symptoms, contact your doctor as soon as you can.

If you are pregnant and taking an SSRI, or other newer antidepressant, you should discuss the risks and benefits of the various treatment options with your doctor. It is very important that you do NOT stop taking these medications without first consulting with your doctor.

Interactions with Wellbutrin XL

If you are taking or have recently been taking other medicines for depression called monoamine oxidase inhibitors (MAOIs) tell your doctor before taking WELLBUTRIN XL.

You should tell your doctor if you are taking or have recently taken any medications (prescription, non-prescription or natural herbal) especially:

  • other antidepressants such as citalopram, paroxetine, venlafaxine.

  • the antipsychotic thioridazine.

  • other medications for mental illness such as haloperidol and risperidone.

  • medicines for Parkinson’s disease such as levodopa, amantadine or orphenadrine.

  • medicines used for epilepsy (such as carbamazepine, phenytoin, or phenobarbitone).

  • cyclophosphamide or ifosfamide, drugs mainly used to treat cancer.

  • drugs called beta blockers to treat heart conditions.

  • medicines to regulate heart rhythm.

  • clopidogrel or ticlopidine, drugs used to reduce blood clots.

  • nicotine patches to help you stop smoking.

  • In general, drinking alcoholic beverages should be kept to a minimum or avoided completely while taking WELLBUTRIN XL.

Proper Use of Wellbutrin XL

Usual dose

How to take WELLBUTRIN XL:

  • WELLBUTRIN XL is formulated to be taken as a single tablet, once-daily.

Major Depressive Disorder:

Dosing with WELLBUTRIN XL Tablets should begin at 150 mg/day given as a single daily dose in the morning. The dose of WELLBUTRIN XL may be increased to the 300 mg/day maximum dose after 1 week. The usual adult target dose for WELLBUTRIN XL Tablets is 300 mg/day, given once daily in the morning.

Prevention of Seasonal Depression:

Dosing with WELLBUTRIN XL Tablets should begin at 150 mg/day given as a single daily dose in the morning. The dose of WELLBUTRIN XL may be increased to the 300 mg/day maximum dose after 1 week. The usual adult target dose for WELLBUTRIN XL Tablets is 300 mg/day, given once daily in the morning. For patients taking 300 mg/day during the autumn-winter season, the dose should be reduced to 150 mg/day for 2 weeks prior to discontinuation.

  • Take your WELLBUTRIN XL tablet at the same time each day. If you have any problems with your dosing routine, contact your doctor or pharmacist.

  • Swallow your WELLBUTRIN XL tablet whole, with fluids. Do not divide, chew or crush tablets.

  • Take only the recommended dose prescribed by your doctor. Never increase the dose of WELLBUTRIN XL you or those in your care are taking, unless your doctor tells you to.

  • The effects of your medication may not be noticeable in the first few days of treatment, and significant improvement may take several weeks. If you are concerned that your medicine is not working, discuss this with your doctor.

  • You should talk to your doctor before you stop taking your medication on your own.

Remember: This medicine has been prescribed only for you. Do not give it to anybody else, as they may experience undesirable effects, which may be serious.

Wellbutrin XL Facts

Biovail Corporation was formed in 1989 when Trimel Corporation acquired the pharmaceutical company Ian French and Associates.

In May 2009, GlaxoSmithKline sold the full rights to Wellbutrin XL to the Canadian pharmaceutical group Biovail Corporation.

U.S. sales of Wellbutrin XL in the first quarter of 2009 were over $73.5 million.

Biovail Corporation, the largest publicly traded pharmaceutical company in Canada, distributes Wellbutrin XL in Canada and the U.S.


Technical Information