Lescol

Lescol Medication Information:

Lescol medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Lescol 20 mg
Lescol 40 mg
Lescol XL 80 mg

About Lescol

What Lescol is used for

LESCOL/LESCOL XL is to be used along with a medically recommended and carefully supervised diet for the long-term treatment of high cholesterol and fatty acids and is not a substitute for such a diet. In addition, depending on your condition, your physician may recommend an appropriate regimen of exercise, weight control and other measures.

LESCOL may be prescribed by your physician if you suffer from coronary heart disease, and have undergone a percutaneous coronary intervention (PCI) (a medical procedure on your heart (or its vessels) that was performed through an incision on your leg or arm), to reduce your risk of developing any major heart problems, such as loss of heart muscle, nonfatal heart attack, or the need to perform other medical procedures on the heart or its vessels.

LESCOL/LESCOL XL is intended for children aged 10 years and older. Your doctor will advise you about the appropriate diet for your child.

What Lescol does

LESCOL/LESCOL XL lower the level of cholesterol, particularly low density lipoprotein (LDL) cholesterol, in the blood. LESCOL/LESCOL XL reduce cholesterol production by the liver and induce some changes of cholesterol transport and the way it is distributed in the blood and tissues.

When Lescol should not be used

Do not take LESCOL/LESCOL XL:

  • if you are hypersensitive (allergic) to fluvastatin or any of the other ingredients of LESCOL/LESCOL XL

  • if you have an active liver disease, or unexplained, persistent elevations in liver function values (transaminases)

  • if you are pregnant or breast-feeding

  • LESCOL and LESCOL XL have not been studied in children under 9 years of age.

What the medicinal ingredient is

Fluvastatin sodium.

What the important nonmedicinal ingredients for Lescol are

LESCOL capsules contain: (alphabetical order) benzyl alcohol, butyl paraben, calcium carbonate, carboxymethyl cellulose sodium, edetate calcium disodium, gelatin, iron oxide red (C.I. # 77491), iron oxide yellow (C.I. # 77492), magnesium stearate, methyl paraben, microcrystalline cellulose, pregelatinized starch, propyl paraben, sodium bicarbonate, sodium laurel sulphate, sodium propionate, talc, titanium dioxide (C.I. # 77891).

LESCOL XL tablets contain: (alphabetical order) hydroxypropyl cellulose, hydroxypropyl methyl cellulose, iron oxide yellow (C.I. # 77492), magnesium stearate, microcrystalline cellulose, polyethylene glycol 8000, potassium bicarbonate, povidone and titanium dioxide (C.I. # 77891).

What dosage forms Lescol comes in

LESCOL Capsules 20 mg and 40 mg.

LESCOL XL Extended Release Tablets 80 mg.


Warnings and Precautions

Pregnancy

LESCOL/LESCOL XL should not be used during pregnancy. Cholesterol is essential for the development of a baby. Cholesterol-lowering drugs can harm the baby. If you become pregnant while using LESCOL/LESCOL XL, stop using the medication immediately and contact your doctor.

BEFORE you use LESCOL/LESCOL XL talk to your doctor or pharmacist if you:

  • have thyroid problems

  • regularly drink three or more alcoholic drinks daily

  • are taking any other cholesterol lowering medication such as fibrates (gemfibrozil, fenofibrate, bezafibrate), niacin or ezetimibe

  • are taking any other medications, including prescription, nonprescription and natural health products as drug interactions are possible, in particular corticosteroids, cyclosporine (NEORAL), fibrates (e.g. gemfibrozil [LOPID]), oral anticoagulants (eg. warfarin [COUMADIN]), phenytoin, oral hypoglycemics, non steroidal anti-inflammatory drugs, erythromycin, lipid lowering doses of niacin (nicotinic acid) nefazodone (SERZONE) and colchicines

  • have a personal or family history of muscular disorders

  • had any past muscle problems (pain, tenderness), after using an HMG-CoA reductase inhibitor (“statin”) such as atorvastatin (LIPITOR), fluvastatin (LESCOL/LESCOL XL), lovastatin (MEVACOR), pravastatin (PRAVACHOL), rosuvastatin (CRESTOR) or simvastatin (ZOCOR) or have developed an allergy or intolerance to any of them

  • have kidney disease

  • have liver problems: liver function tests will normally be done before starting LESCOL/LESCOL XL, at dose increase and at various intervals during treatment to check for undesirable effects.

  • have diabetes

  • have undergone surgery or other tissue injury

  • do excessive physical exercise

  • have low blood pressure

  • have congestive heart failure

  • suffer from seizures

  • If you are older than 70 years your doctor may want to clarify whether you have risk factors for muscular diseases. This may require specific blood tests.

  • In adolescents and children, the safety of LESCOL/LESCOL XL for a prolonged treatment period on their physical, intellectual and sexual maturation has not been established.

Your doctor will monitor your progress with LESCOL/LESCOL XL and may occasionally perform some tests to ensure your health and safety.


Interactions with Lescol

Drugs that may interact with LESCOL/LESCOL XL include:

  • corticosteroids

  • cholestyramine

  • gemfibrozil/fenofibrate/bezafibrate/niacin

  • cimetidine/ranitidine/omeprazole

  • digoxin

  • rifampicin

  • warfarin and other coumarin derivatives

  • phenytoin

  • fluconazole

  • oral hypoglycemic agents (e.g. tolbutamide, chlorpropamide, glyburide)

  • non-steroidal anti-inflammatory drugs (NSAIDs)

  • nefazodone

  • alcohol

  • spironolactone

  • amlodipine

  • cyclosporine

Notify your physician about any illness which may develop during your treatment with LESCOL/LESCOL XL and about any new prescription or nonprescription medication you may take. If you require medical help for other reasons, inform the attending physician that you are taking LESCOL/LESCOL XL.

In adolescents and children, no information on specific drug interactions with LESCOL/LESCOL XL is available.


Proper Use of Lescol

Use only as specifically directed. Do not alter the dosage unless ordered to do so by your physician. Check with your physician before discontinuing medication since this may result in an increase of your fat substances in the blood.

Usual dose, limit to people older than 10 years

  • If your doctor recommends you take only 1 dose of LESCOL per day, take it in the evening or at bedtime or LESCOL XL at any time of the day. If your doctor recommends taking divided doses (2 times per day), take one in the morning and one in the evening.

  • LESCOL/LESCOL XL can be taken with or without food, but continue to take it the same way (either with OR without food) each time. Swallow LESCOL/ LESCOL XL whole with a glass of water.

  • Do not change the dose unless directed by a doctor.

  • Your physician will monitor your clinical condition and your blood tests at regular intervals. It is important to have these check-ups done on schedule. Please keep your appointments accurately.

  • Notify your physician if you are going to have major surgery or have sustained a severe injury.

Overdose

If you take more LESCOL/LESCOL XL than you should, tell your doctor immediately or go to your nearest hospital.

For management of a suspected drug overdose, contact your regional Poison Control Centre.

Missed dose

If you forget to take LESCOL/LESCOL XL, take one dose as soon as you remember.

Do not take a double dose to make up for the one that you missed.


Side Effects for Lescol and What to Do About Them

Along with its intended action, any medication may cause unwanted effects.

Other side effects may occasionally occur which usually do not require stopping treatment. They may come and go during treatment without any particular danger, but you should mention them to your physician, without undue delay, if they become persistent or bothersome. Such adverse experiences include:

  • abdominal pain/indigestion,

  • constipation

  • diarrhea

  • nausea

  • headache

  • influenza

  • infections

  • insomnia and

  • dizziness.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Rare Muscle pain that you cannot explain, muscle tenderness or muscle weakness    
Skin rash, hives, swelling of the face, eyelids and lips    
Very Rare Brownish or discoloured urine    
Generalized weakness, especially if you do not feel well (i.e. fever or fatigue)    
Myositis (muscle inflammation), rhabdomyolysis (a muscle wasting disease)    
Unusual tiredness or fever, yellowing of the skin and eyes, dark coloured urine (hepatitis)    
Severe abdominal pain (inflamed pancreas)    
Skin swelling, rash, hives, dizziness (signs of severe allergic reaction)    
Difficulty in breathing, swelling of the lips, throat, mouth, tongue or face (signs of severe allergic reaction)     • immediately

This is not a complete list of side effects. For any unexpected effects while taking LESCOL/LESCOL XL, contact your doctor or pharmacist.


 

Technical Information