Bonefos 400 mg

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Best Value On Brand Bonefos 400 mg
Price: $3.44 per capsule!
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Bonefos 400 mg Prescription Required
120 capsules for $412.49 ($3.44 per capsule)
Bonefos from online pharmacy: Canada
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Bonefos 400 mg is available from our online pharmacy for less money than you'd spend locally. If you like the convenience of ordering from your home, you can order your prescription online, or speak with one of our customer service representatives on the phone. Call us, The Drug Company, toll free at 1-888-254-3038. Prior to taking Bonefos 400 mg, please consult with your doctor or health professional to see if this medication is right for you. Many customers have saved even more money by speaking with their doctor about a generic substitute.

About Bonefos

What Bonefos is used for

BONEFOS is used:

  • for the management of hypercalcemia due to malignancy (high blood calcium in adult patients who have cancer), and

  • as an adjunct in the management of osteolytic bone metastases (bone destruction when cancer cells have spread to the bone)

What Bonefos does

BONEFOS belongs to a group of medicines called bisphosphonates. BONEFOS binds tightly to bone and blocks the function of cells which re-absorb bone. This strengthens the bones, and thus helps to relieve bone pain and prevent future problems with your bones (such as fractures). It also prevents the release of too much calcium into the blood (hypercalcemia).

When Bonefos should not be used

You should not take BONEFOS if any of the following conditions apply to you.

  • You have severe kidney disease.

  • You have severe stomach or bowel problems.

  • You are pregnant or breast-feeding.

  • You are being treated with another bisphosphonate.

  • You have an allergy to bisphosphonates, clodronate disodium, or to any ingredient in the formulation or component of the container of BONEFOS.

What the medicinal ingredient is

Clodronate disodium.

What the important nonmedicinal ingredients for Bonefos are


calcium stearate, colloidal anhydrous silica, gelatin, iron oxide (red and yellow), lactose, talc, titanium dioxide.

Solution for injection

sodium hydroxide, water for injection.

What dosage forms Bonefos comes in


Each yellow BONEFOS capsule contains 400 mg of clodronate disodium. BONEFOS capsules are provided in plastic bottles containing 120 capsules.

Solution for Injection

BONEFOS solution for injection is available in 5 mL glass ampoules containing anhydrous clodronate disodium 60 mg/mL. The solution must be diluted prior to infusion.

Warnings and Precautions

BEFORE starting treatment with BONEFOS talk to your doctor if:

  • you suffer from kidney problems, as your dose may need to be reduced.

  • you have stomach or bowel problems.

  • you are pregnant or planning to become pregnant. BONEFOS should not be given during pregnancy.

  • you are breast-feeding. Mothers being treated with BONEFOS should not breast-feed their children.

  • you have ever had an allergic reaction to BONEFOS (or similar medicines called bisphosphonates) or any other ingredients of the drug or components of the container.

  • you are presently taking another bisphosphonate.

  • you have any dental problems or any dental procedures planned in the future.

Osteonecrosis (pronounced OSS-tee-oh-ne-KRO-sis) of the jaw, a rare condition that involves the loss or breakdown of the jaw bone, has been reported in patients with cancer receiving bisphosphonates. It is not known what role, if any, these medications played in its development. The majority of the cases were associated with dental procedures. Other possible factors that may increase the risk of osteonecrosis of the jaw include:

  • chemotherapy;

  • radiation therapy;

  • steroid therapy (e.g., cortisone);

  • underlying cancer;

  • anemia (low red blood cell count);

  • infection; and

  • poor dental health or poor oral hygiene.

If any of these risk factors applies to you, you should have a dental exam prior to starting treatment with BONEFOS. Be sure to tell your dentist about your cancer diagnosis and treatments.

The effect of BONEFOS on the ability to drive or use machines is not known.

Since there is no clinical experience in children, BONEFOS is only recommended for use in adult patients.

Interactions with Bonefos

Before you start treatment with BONEFOS, be sure to tell your doctor about any other prescription or over-the-counter medicines that you are using or intend to use.

Medicines that may interact with BONEFOS include:

  • non-steroidal anti-inflammatory drugs (NSAIDs), especially diclofenac;

  • other bisphosphonates;

  • other calcium-reducing agents, including corticosteroids, phosphate, calcitonin, mithramycin or loop diuretics (e.g., furosemide);

  • aminoglycoside antibiotics;

  • estramustine phosphate;

  • antacids; and

  • dietary supplements containing calcium, iron, magnesium or aluminum.

BONEFOS capsules should be taken on an empty stomach, with a glass of plain water, at least 2 hours before or after food, because food may decrease the amount of BONEFOS absorbed by the body.

Proper Use of Bonefos

Usual dose

Your doctor will determine the appropriate dose for you. Follow the dosing instructions exactly and ask your doctor or pharmacist if you are not sure.

BONEFOS for Injection

  • 300 mg/day is given as a slow infusion into a vein.

BONEFOS Capsules

  • Hypercalcemia due to malignancy: 1600 mg to 2400 mg (four to six capsules) daily. Maximum daily dose is 3200 mg (eight capsules). The daily dose can be taken once, or in two divided doses.

  • Osteolytic bone metastasis due to malignancy: starting dose of 1600 mg (four capsules) daily. Maximum daily dose is 3200 mg (eight capsules).

BONEFOS capsules are to be taken on an empty stomach, with a glass of plain water, at least two hours before or after food.

BONEFOS capsules should be swallowed whole.

You will need to drink enough fluid or be hydrated during treatment with BONEFOS.


If you think you have taken or given more BONEFOS than you should, contact your doctor or a poison control centre immediately.

Missed dose

If a dose of this medication has been missed, it should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Do not double doses.

Technical Information