Dostinex 0.5 mg

Generic Name: Cabergoline 0.5 mg
Dostinex 0.5 mg Image

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Dostinex Facts

Dostinex contains the active ingredient cabergoline, which suppresses prolactin production in the pituitary gland.

The active ingredient in Dostinex was discovered by the Italian drug company Farmitalia-Carlo Erba in 1981.

The scientists who invented the active ingredient in Dostinex were experimenting with derivatives of the toxic plant fungus ergot.

The active ingredient in Dostinex was not approved by the FDA until 2002, when the manufacturer Pharmacia was acquired by Pfizer.


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About Dostinex

What Dostinex is used for

DOSTINEX is used:

  • in the treatment of hyperprolactinaemia (abnormally-high levels of prolactin in the blood);

  • in the prevention of the production of breast milk in women after child birth, if it is medically advisable not to breast-feed.

What Dostinex does

DOSTINEX works by acting on a gland called the pituitary which is located at the base of the brain. By stimulating this gland, it prevents the production of the hormone prolactin.

When Dostinex should not be used

Do not take DOSTINEX if you:

  • are allergic to cabergoline or ergot-like drugs or any of the ingredients in DOSTINEX;

  • have uncontrolled high blood pressure;

  • have heart valve problems (cardiac valvulopathy);

  • have or have had lung or heart problems related to fibrotic tissues (tissues are hardened due to scarring.)

What the medicinal ingredient is

Cabergoline.

What the important nonmedicinal ingredients for Dostinex are

Leucine and lactose.

What dosage forms Dostinex comes in

DOSTINEX 0.5 mg tablets are scored, flat, white, and capsule-shaped. Each tablet contains 0.5 mg cabergoline.


Warnings and Precautions

BEFORE you use DOSTINEX talk to your doctor or pharmacist if you:

  • are pregnant or plan to get pregnant;

  • are breast feeding or plan to breast feed;

  • have kidney problems,

  • have liver problems,

  • have cardiovascular problems (high or low blood pressure);

  • have Raynaud’s syndromes (resulting from poor blood circulation in the extremities such as fingers and toes which may turn blue and feel cold);

  • have ulcer or bleeding in the stomach or intestines;

  • have had pregnancy complications with high blood pressure (preeclampsia or eclampsia);

  • have a history of mental illness.

Reversible pathological gambling and increased sex drive (libido, hypersexuality) have been reported in patients who are treated with dopamine agonists including DOSTINEX.

Aggression has been reported in patients who are treated with dopamine agonists including DOSTINEX.

DOSTINEX may cause sleepiness. Do not drive, operate machinery, or engage in any activities that requires alertness while taking DOSTINEX.

Safety and effectiveness of DOSTINEX in children have not been established.


Interactions with Dostinex

Tell your doctor or pharmacist about your other medicines, including the one you buy without prescription and natural health products. Drugs interact with DOSTINEX include:

  • medicines to treat high blood pressure;

  • medicines contain ergot alkaloids (e.g., to treat migraine headache);

  • macrolide antibiotic (e.g., erythromycin);

  • dopamine antagonists such as medicines to treat mental illness and prevent nausea (e.g., phenothiazines, butyrophenones, metoclopramide).

While taking DOSTINEX

Tell your doctor and pharmacist that you are taking DOSTINEX if you are about to start taking any new medicines.


Proper Use of Dostinex

Usual dose

Adults

Follow your doctor’s instructions carefully about how much DOSTINEX to take and when to take it.

To treat hyperprolactinaemia: initial dose is 0.5 mg per week as single dose or two divided doses. The dose may be increased monthly. Recommended dose ranges from 0.25 mg to 2 mg per week.

To prevent the production of milk, the recommended dose is two tablets taken once, on the first day after delivery of the child.

DOSTINEX should be swallowed, preferably with food.

Overdose

Do not take more tablets than your doctor has told you to. If you take too many tablets by accident, call your doctor or pharmacist immediately or your regional poison control centre.

Missed dose

If you should forget to take your tablet at the usual time, take it as soon as you remember up to 1 day before your next scheduled dose. Do not double dose.


Side Effects for Dostinex and What to Do About Them

Like many medicines, DOSTINEX may cause side effects.

Tell your doctor or pharmacist right away if you suffer from any of the following side effects while taking this medication:

  • dizziness

  • headache

  • nausea or vomiting

  • constipation

  • abdominal pain, or heartburn, or pain in the stomach

  • weakness or tiredness

  • breast pain

  • hot flashes

  • depression

  • shortness of breath

  • swelling

The most common side effects are nausea, headache, dizziness/vertigo, decreases in blood pressure without any symptoms and abdominal pain. Less commonly reported side effects are palpitations, pain in the upper middle of the abdomen, somnolence, nose bleeding, and temporary blindness in one half of the visual field of one or both eyes.

Check with your doctor or pharmacist right away if you have any problems while taking DOSTINEX, even if you do not think the problems are connected with the medicine or are not listed in this leaflet.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Low blood pressure    
Fainting    

This is not a complete list of side effects. For any unexpected effects while taking DOSTINEX, contact your doctor or pharmacist.


Technical Information