Lovenox

Lovenox Medication Information:

Price Break On Lovenox
Generic is available for less money: Generic Clexane injection

Lovenox medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Lovenox 30mg/0.3ml
Lovenox 40mg/0.4ml
Lovenox 60mg/0.6ml
Lovenox 80mg/0.8ml
Lovenox 100 mg/mL

About Lovenox

What Lovenox is used for

LOVENOX is used:

  • to prevent the formation of deep vein thromboses (blood clots), which can occur as a complication of orthopedic surgery such as hip or knee surgery or of intra-abdominal (inside the body cavity below diaphragm which contains stomach, intestines, liver, and other organs) surgeries;

  • to prevent the formation of deep vein thrombosis in medical patients who are at risk of thromboembolic (blockage of blood vessel by a blood clot) complications due to severely restricted mobility during acute illnesses (cardiac insufficiency [reduced ability of heart to pump blood], respiratory failure or severe chest infections);

  • to treat the deep vein thrombosis with or without pulmonary embolism (blockage of blood vessel in the lungs);

  • to treat the unstable angina and non-Q-wave myocardial infarction (death of a part of the heart muscle that does not involve full thickness of the heart wall), concurrently with acetylsalicylic acid (ASA).

  • to treat the acute ST-segment Elevation Myocardial Infarction (STEMI), a particular form of heart attack. This indication includes patients to be managed medically or those with subsequent Percutaneous Coronary Intervention (PCI), a procedure that opens up a coronary artery (blood vessel that brings blood and oxygen to the heart muscle) and restores blood flow.

What Lovenox does

LOVENOX is an anti-thrombotic drug. This means that Lovenox helps to prevent blood clots from forming in patients who have either undergone surgery or are suffering from a medical condition that limits their mobility. It can also treat existing blood clots in deep veins or in unstable coronary artery disease (Unstable Angina or non Q-wave Myocardial Infarction).

When Lovenox should not be used

LOVENOX should not be used when you have any of the following:

  • a known allergy to LOVENOX or any of its constituents, including benzyl alcohol (when using multidose multiple vials);

  • a known allergy to any other low molecular weight heparins and/or heparin;

  • thrombocytopenia (a severe decrease in the number of platelets in the blood);

  • bacterial endocarditis (bacterial infection inside of the heart);

  • active bleeding;

  • a major clotting disorder;

  • gastric or duodenal ulcer (defect of the internal walls of the stomach or small intestine);

  • cerebrovascular accident (except if there are systemic emboli);

  • severe uncontrolled hypertension (high blood pressure);

  • eye problems due to diabetes or hemorrhage (bleeding);

  • a tendency to bleeding regardless of the reason;

  • injury or surgery on the brain, spinal cord, eyes and ears;

  • kidney problems;

  • liver problems;

  • spinal/epidural anaesthesia is contraindicated where repeated treatment doses of LOVENOX (1 mg/kg every 12 hours or 1.5 mg/kg once daily) are required, due to an increased risk of bleeding;

  • other conditions or diseases involving an increased risk of hemorrhage.

What the medicinal ingredient is

LOVENOX contains enoxaparin sodium, a low molecular-weight heparin.

What the important nonmedicinal ingredients for Lovenox are

The pre-filled syringe contains water for injection.

The multiple dose vial contains benzyl alcohol as a preservative and water for injection.

What dosage forms Lovenox comes in

LOVENOX 100 mg/mL is available in pre-filled syringes offered with a system that shields the needle after injection and in multiple dose vials:

  • Single dose 30 mg/0.3 mL pre-filled syringes with protective shield

  • Single dose 40 mg/0.4 mL pre-filled syringes with protective shield

  • Single dose 60 mg/0.6 mL pre-filled syringes with protective shield

  • Single dose 80 mg/0.8 mL pre-filled syringes with protective shield

  • Single dose 100 mg/1.0 mL pre-filled syringes with protective shield

  • Multiple dose vials 300 mg/3 mL.

Also available:

LOVENOX HP 150 mg/mL pre-filled syringes offered with a system that shields the needle after injection and in multiple dose vials:

  • Single dose 120 mg/0.8 mL pre-filled syringes with protective shield

  • Single dose 150 mg/1.0 mL pre-filled syringes with protective shield


Warnings and Precautions

WHAT YOU SHOULD TELL YOUR DOCTOR BEFORE TREATMENT WITH LOVENOX: It is important that you provide your doctor with an accurate history of any serious illnesses you may have had in the past or any current medical conditions, as these may influence the action of LOVENOX.

Therefore, tell your doctor if you have had or currently have any of the following conditions:

  • prosthetic (artificial) heart valve,

  • stroke (cerebrovascular accident),

  • a known allergy to LOVENOX or any of its constituents, or to other low molecular weight heparins and/or heparin,

  • thrombocytopenia (a severe decrease in the number of platelets in the blood),

  • bacterial endocarditis (bacterial infection inside of the heart),

  • a major clotting disorder,

  • gastric or duodenal ulcer (defect of the internal walls of the stomach or small intestine),

  • hypertension (high blood pressure),

  • a tendency to bleeding regardless of the reason,

  • injury or surgery involving the central nervous system, eyes or ears,

  • kidney problems,

  • liver problems,

  • eye problems due to diabetes or hemorrhage (bleeding).

You should also inform your doctor at once if you are pregnant or if you are breast-feeding, so he can evaluate the possible risks to you and the infant.

Certain medications may intensify the anticoagulant effect (increase the anti-clotting effect) of LOVENOX. Therefore, it is important for you to advise your doctor of all drugs that you are presently taking.

It is necessary that you follow the instructions of your doctor or nurse carefully. Only give yourself the injections prescribed and do so the entire time period specified by your doctor.

Do not take any drugs other than those prescribed by your doctor while you are taking LOVENOX.

If you need to consult with another doctor or see your dentist, be absolutely sure to tell them that you are being treated with LOVENOX.


Interactions with Lovenox

LOVENOX should be used with caution in conjunction with other drugs that affect blood clotting (i.e. acetylsalicylic acid (ASA), salicylates, dextran, vitamin K antagonists).


Proper Use of Lovenox

Usual Dose

LOVENOX is a prescription drug and must be used as directed. Usually it is administered as a subcutaneous injection, which means the injection is made just under the surface of the skin. For some conditions, LOVENOX may be administered as an intravenous (IV) injection.

Hip or Knee Replacement Surgery: While you are in the hospital, your doctor or a nurse will give your first injection within 24 hours after your operation, so as to prevent blood clots from forming. After that, your doctor or a nurse will give you 2 subcutaneous injections every day (one injection every 12 hours) while you are in hospital.

In case of hip replacement surgery, after completing the treatment with 2 subcutaneous injections per day, your doctor may ask you to take 1 subcutaneous injection every day for the following days at home or in hospital for an additional 3 weeks.

Abdominal or Colorectal Surgery: While you are in the hospital, your doctor or a nurse will give your first injection 2 hours prior to surgery. After that, your doctor or a nurse will give you 1 subcutaneous injection once a day while you are in hospital.

Medical Patients: While you are in the hospital, your doctor or a nurse will give you 1 subcutaneous injection once a day. The usual duration of administration is 6 to 11 days.

Treatment of Deep Vein Thrombosis, with or without Embolism: while you are in the hospital, your doctor or a nurse will give you 1 subcutaneous injection once or twice daily for about 10 days.

Treatment of Unstable Angina or Non-Q-Wave Myocardial Infarction: while you are in the hospital, your doctor or a nurse will give you 2 subcutaneous injections every day (one injection every 12 hours) along with oral ASA (100 to 325 mg once daily) for a minimum of 2 days.

Treatment of acute ST-segment Elevation Myocardial Infarction (STEMI): while you are in the hospital, your doctor or a nurse will give you a single intravenous (IV) injection followed by 2 subcutaneous injections every day (one injection every 12 hours) along with oral ASA (75 to 325 mg once daily) for a minimum of 8 days, unless contraindicated.

It is possible that after you go home, you may need to continue your injections of LOVENOX for a few days.

Instructions for self-injection of LOVENOX

(See package insert for illustrations.)

Your doctor may want you to continue your LOVENOX injections at home for a few days. If so, he or a nurse will show you how to administer your LOVENOX injections before you are released from hospital. It is essential that you follow these instructions exactly. If you have questions, be sure you ask your doctor or nurse to provide the explanations you require.

Proper subcutaneous (under the skin) injection of LOVENOX is essential to prevent pain and bruising at the injection site.

When at home, there is nothing for you to prepare. The syringe is prefilled with the exact amount of drug required. Do not press on the plunger prior to injection.

LOVENOX solution should be inspected visually for clarity, particulate matter, precipitation, discolouration, and leakage prior to administration. Do not use if solution shows haziness, particulate matter, discolouration or leakage.

The recommended site for injection is into the fat of the lower abdomen. This should be at least 5 centimeters away from your belly button and out towards your sides.

Prior to injection, wash your hands and cleanse (do not rub) the selected site for injection with an alcohol swab. Select a different site of lower abdomen for each injection.

Remove the needle cover by pulling it straight off the syringe. If adjusting the dose is required, the dose adjustment must be done prior to injecting LOVENOX.

NOTE: To avoid the loss of drug when using the 30 and 40 mg pre-filled syringes, do not expel the air bubble from the syringe before the injection.

Lie down on your back and gather a fold of skin with your thumb and forefinger.

Then holding the needle at a right angle to the skin folded between your thumb and forefinger, insert the needle as far as it will go. Hold the skin fold throughout the injection process. Once the needle has been inserted, the syringe should not be moved. Push the plunger to inject LOVENOX. Be sure the syringe is empty and the plunger is pushed all the way down before removing the syringe.

Remove the needle at a right angle, by pulling it straight out. A protective sleeve will automatically cover the needle.

NOTE: the safety system allowing release of the protective sleeve can only be activated when the syringe has been emptied by pressing the plunger all the way down.

You can now let go of the skin fold and apply light pressure to the skin at the injection site for several seconds with an alcohol swab. This action will help lessen any oozing of LOVENOX or bleeding. Do not rub the injection site.

You should then safely dispose of the syringe and needle with its protective sleeve, so they remain out of reach of children.

Overdose

Accidental overdosage may result in hemorrhaging, which cannot be treated at home. Therefore, if you suspect that you have used too much LOVENOX, call your doctor immediately even if you do not yet observe any unusual symptoms. Your doctor can then make arrangements to bring you to hospital for observation and/or treatment.

For management of a suspected drug overdose, contact your regional Poison Control Centre.

Missed dose

If you miss a dose of this medication by a few hours, take it as soon as you remember. However if you are close to the time of the next dose, skip the missed dose and proceed with the regular dosing schedule. Do not double doses. If you are unsure about how to proceed contact your doctor or your pharmacist.


Side Effects for Lovenox and What to Do About Them

Administration of LOVENOX may result in bleeding which can have serious or life-threatening consequences. Hemorrhagic strokes (bleeding inside of the brain) and serious intra-abdominal bleeding (bleeding into the body cavity below diaphragm which contains stomach, intestines, liver, and other organs) have been reported. LOVENOX is generally well tolerated when used according to directions of use.

During your hospital stay or when using LOVENOX at home, it is important that you notify your doctor immediately if you notice any of the following symptoms which may be a sign of an underlying complication:

  • Bleeding or oozing from the surgical wound;

  • Any other bleeding episodes, for example, at the site of the injection, nosebleeds, blood in the urine or if you cough or throw up blood, or have bloody stools;

  • Bleeding gums while brushing teeth;

  • Spontaneous bruising (a bruise not caused by a blow or any apparent reason);

  • Purplish or reddish discolouration or pain around the injection site;

  • Skin discolouration as caused by ruptured blood vessels;

  • Pain or swelling in any part of your leg, foot or hip;

  • Dizziness; Headache;

  • Rapid or unusual heart beat;

  • Chest pain or shortness of breath;

  • Vomiting;

  • Confusion;

  • Abdominal pain.

This is not a complete list of side effects. For any unexpected effects while taking LOVENOX, contact your doctor or pharmacist.


About Lovenox

 

Technical Information