Tarka

Tarka Medication Information:

Tarka medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Tarka 2mg/180mg
Tarka 2mg/240mg
Tarka Forte 240mg/4mg

About Tarka

What Tarka is used for

TARKA is used to treat hypertension (high blood pressure).

Both trandolapril and verapamil should normally be used in those patients in whom treatment with a diuretic or a beta-blocker were found to be ineffective or were associated with unacceptable adverse effects. They can be tried as initial agents in those patients in whom diuretics and/or beta-blockers are contraindicated or in patients with medical conditions in which these drugs frequently cause serious adverse effects.

What Tarka does

TARKA contains two different types of medicines: a calcium channel blocker and an Angiotensin Converting Enzyme (ACE) inhibitor.

Calcium channel blockers change the amount of calcium getting into the muscle cells of your heart and blood vessels. This can change the strength and speed at which your heart beats. It also opens up the blood vessels so that blood can be pumped around your body more easily. This helps to lower your blood pressure.

ACE inhibitors also work by widening blood vessels, so helping to lower your blood pressure.

When Tarka should not be used

TARKA should not be used if:

  • you are allergic to any component of TARKA, including active ingredients and non-active ingredients

  • you are pregnant or breast feeding or

  • you have certain serious heart conditions.

Ask your doctor for advice.

What the medicinal ingredient is

TARKA contains the ACE inhibitor trandolapril and the calcium channel blocker verapamil hydrochloride. The tablet consists of two layers, one layer containing trandolapril, and the other layer containing verapamil hydrochloride in a sustained-release matrix.

What the important nonmedicinal ingredients for Tarka are:

Corn starch, dioctyl sodium sulfosuccinate, hydroxypropyl cellulose, hydroxypropyl methylcellulose, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, povidone, purified water, silicon dioxide, sodium alginate, sodium stearyl fumarate, synthetic iron oxides, talc, titanium dioxide.

What dosage forms Tarka comes in

TARKA is available as sustained-release tablets in the following strength combinations of trandolapril/verapamil hydrochloride: 2/240 mg; 4/240 mg.


Warnings and Precautions

Serious Warnings and Precautions

When used in pregnancy, ACE inhibitors, such as trandolapril in TARKA, can cause injury and even death to the developing fetus. When pregnancy is detected, TARKA should be discontinued as soon as possible.

BEFORE you use TARKA talk to your doctor or pharmacist if:

  • you are pregnant or planning to become pregnant, or you are breast-feeding.

  • you have any heart disease

  • you have kidney disease

  • you are taking beta-blockers;

  • you have neuromuscular disease (i.e. myasthenia gravis or Duchenne muscular dystrophy)

  • you have hepatic failure or elevated liver enzymes;

  • you have allergies to this drug or any of its ingredients.


Interactions with Tarka

Drugs that may interact with TARKA include:

  • Beta-blockers (e.g., propranolol);

  • Any other treatment for hypertension (high blood pressure) or an arrhythmia (abnormal heart beat) (e.g., hydrochlorothiazide, procainamide);

  • Digoxin, cimetidine, lithium, rifampin or theophylline;

  • Carbamazepine and phenobarbital;

  • Any of the group of medicines known as major tranquilizers, or an antidepressant of the tricyclic group (e.g. lorazepam, imipramine);

  • Diuretics (water tablets), potassium supplements or any of the group of medicines known as non-steroidal anti-inflammatory drugs (e.g., hydrochlorothiazide, potassium chloride, naproxen);

  • Anti-cancer medication (e.g., cisplatin)

  • Any medication that can affect your immune system (e.g. corticosteroids or cyclosporine);

  • Any neuromuscular blocking agent (e.g., atracurium)

  • Some anti-cholesterol products (e.g., simvastatin, lovastatin).


Proper Use of Tarka

Usual dose

Dosage must be individualized. The fixed combination is not for initial therapy. The dose of TARKA should be determined by titration of the individual components. TARKA should be taken once-a-day at the same time every day.

The usual adult dose for verapamil monotherapy is 180 to 240 mg/day.

The usual maintenance dose for trandolapril monotherapy is 1 to 2 mg once daily, as the recommended initial dose is 1 mg once daily.

Take TARKA with food to help it work better. TARKA sustained-release tablets should not be divided, crushed or chewed.

Overdose

If you or someone you know accidentally takes more than stated dose, contact your doctor immediately or go to the nearest hospital with the tablets. Tell your doctor or hospital how much was taken. Treat even small overdoses seriously.

Missed dose

If you forget to take one tablet, take another as soon as you remember, unless it is almost time for your next dose. If it is, do not take the missed tablet at all.

Never double-up on a missed dose.


Side Effects for Tarka and What to Do About Them

Along with its needed effects, a medicine may cause some unwanted effects. These are referred to as “side effects”. Although not all of these side effects may occur, if they do occur they may need medical attention.

The most common side effects with TARKA are dry cough, constipation and mild dizziness. Other less common side effects may include headaches, feeling sick (nausea), dry mouth, hair loss, nasal congestion, flushing of the face or neck, aches or pains in the joints of muscles, tiredness, swollen ankles, mild skin rash or itching, tingling or pickling of the skin, difficulty in sleeping, impotence, blurred vision, taste disturbance, anaemia or low numbers of white blood cells.

Check with your physician or pharmacist if you experience any unexpected effects, or are concerned by the above side effects.

Symptoms of Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Uncommon Chest pain, faint pulse, irregular heartbeats  
Fever and chills  
Swelling of the face, mouth, tongue, trouble with swallowing or breathing  
Dizziness, lightheadedness, fainting  

Check with your pharmacist or doctor immediately, if you experience any of the above symptoms of the serious side effects.


 

Technical Information