Rasilez Medication Information:

Rasilez medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Rasilez 150 mg
Rasilez 300 mg
Rasilez Hctz 300mg/12.5mg

About Rasilez

What Rasilez is used for

Rasilez is a medication that helps to control hypertension (high blood pressure).

High blood pressure increases the workload of the heart and arteries. If this condition continues for a long time, damage to the blood vessels of the brain, heart, and kidneys can occur, and may eventually result in a stroke, heart failure or kidney failure. High blood pressure also increases the risk of heart attacks. Reducing your blood pressure decreases your risk of developing these illnesses.

What Rasilez does

Rasilez belongs to a new class of medicines called “direct renin inhibitors”, which help to control high blood pressure. Rasilez works differently than other anti-hypertensive agents. It can be used alone or in combination with selected other agents to get a better reduction of the blood pressure. Renin inhibitors prevent the body from producing angiotensin II, a substance that causes blood vessels to tighten, thus increasing blood pressure. As a result, blood vessels relax and blood pressure is lowered.

When Rasilez should not be used

You should not take Rasilez if:

  • You have ever had an unusual or allergic reaction to aliskiren or to any other component of this product (see below)

  • You are pregnant or plan to become pregnant

  • You are breast-feeding

Rasilez is not recommended for use in patients under 18 years of age.

What the medicinal ingredient is

The medicinal ingredient is aliskiren.

What the important nonmedicinal ingredients for Rasilez are

Rasilez also contains the following nonmedicinal ingredients: microcrystalline cellulose, crospovidone, povidone, magnesium stearate, silica colloidal anhydrous, macrogol, talc, hypromellose, titanium dioxide (E171), red iron oxide (E172), black iron oxide (E172).

What dosage forms Rasilez comes in

Rasilez is available as 150 and 300 mg coated tablets.

Warnings and Precautions

Serious Warnings and Precautions

Rasilez should not be used during pregnancy. If you discover that you are pregnant while taking Rasilez, stop the medication and contact your physician as soon as possible.

BEFORE you use Rasilez talk to your doctor or pharmacist if:

  • You have or have had an impaired kidney function.

  • You have gastro-intestinal problems.

  • You are on a salt restricted diet.

  • You are already taking another medicine to lower blood pressure.

  • You are pregnant, think you may have become pregnant or are planning to become pregnant.

  • You are breast-feeding.

  • You are taking cyclosporine (a medicine used in transplantation to prevent organ rejection or for other conditions, e.g. rheumatoid arthritis or atopic dermatitis).

If any of these apply to you, tell your doctor before you take Rasilez.

Pregnant Women

Do not take Rasilez if you are pregnant. Similar medicines were associated with serious harm to fetuses when they were taken during pregnancy. It is therefore important to tell your doctor immediately if you think you may have become pregnant, or planning to become pregnant.

Breast-feeding Mothers

Although it is not known whether Rasilez can pass into human breast milk, this does happen in animals. Tell your doctor if you are breast-feeding. You should not breast-feed if you are taking Rasilez, as it might be harmful for your infant.

Interactions with Rasilez

Tell your doctor or pharmacist about any medicines you are taking or have recently taken, including prescription medications (the ones your doctor writes for you) and over-the-counter medications (the ones you buy in the drugstore, like cold or allergy medicines), or natural health products (herbal medicines).

Drugs that may interact with Rasilez:

  • Furosemide, a medicine used to increase the amount of urine (diuretic)

  • Irbesartan, a medicine used to also lower the blood pressure

  • Ketoconazole, a medicine used to treat fungal infections

  • Cyclosporine, a medicine used to prevent graft rejection or for other conditions, e.g. rheumatoid arthritis or atopic dermatitis (red, flaky, itchy skin)

  • Potassium-sparing diuretics, potassium-containing medicines, potassium supplements, or salt substitutes containing potassium

Proper Use of Rasilez

Remember that this medicine does not cure your high blood pressure; it only may help to control it. Therefore, if you want to lower your blood pressure and keep it down, you must continue to take Rasilez as directed.

Patients who have high blood pressure often do not notice any signs or symptoms of this condition. Indeed, many may feel quite normal for a long time. So even though you are feeling well, your health may be getting worse. This makes it all the more important for you to continue your treatment program and to keep your appointments with your doctor.

Usual dose

The usual starting dose is one 150 mg tablet once a day. In some cases, your doctor may prescribe a higher dose (e.g. 300 mg tablet) or an additional medicine used to treat high blood pressure. Rasilez may be used over a dosage range of 150 mg to 300 mg once daily. Depending on how you respond to the treatment, your doctor may suggest a higher or lower dose.

How to use Rasilez

Follow your doctor’s instructions carefully. Do not exceed the recommended dose (300 mg once daily).

When and how to take Rasilez

Swallow Rasilez tablets whole with a small amount of water. Do not chew or crush the tablets. You can take Rasilez with or without food, but it should be taken the same way each day and at the same time.

How long to take Rasilez

Follow your doctor’s instructions exactly. Your doctor will tell you for how long you should take Rasilez.


If you have accidentally taken too many tablets, seek medical assistance immediately.

For management of a suspected drug overdose, contact your regional Poison Control Centre.

Missed dose

If you miss a dose of this medicine, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Side Effects for Rasilez and What to Do About Them

Like all medicines, Rasilez may cause unwanted side effects in some people. The following side effects have been reported with patients taking Rasilez:

  • nasopharyngitis (common cold)

  • diarrhea

  • edema (accumulation of fluid in tissues that can cause swelling)

  • constipation

  • headache

  • dizziness

  • fatigue

  • influenza

  • back pain

If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacista
Only if severe In all cases
Uncommon Severe diarrhea    
Swelling of the face, nose, lips or tongue that can lead to discomfort when swallowing or difficulty in breathing    
a. If you think you have these side effects, it is important that you seek medical advice from your doctor immediately.

This is not a complete list of side effects. For any unexpected effects while taking Rasilez, contact your doctor or pharmacist.


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