Coversyl Plus 4mg/1.25mg

Generic Name: Perindopril/Indapamide 4mg/1.25mg
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About Coversyl Plus

What Coversyl Plus is used for

COVERSYL PLUS LD is a combination of two active ingredients, perindopril and indapamide. Your doctor has prescribed COVERSYL PLUS LD to treat your mild to moderate hypertension. Hypertension is the medical term for high blood pressure.

What Coversyl Plus does

Perindopril belongs to a class of medicines called ACE inhibitors. These work by widening the blood vessels, which makes it easier for your heart to pump blood through them. Indapamide is a diuretic. Diuretics increase the amount of urine produced by the kidneys. However, indapamide is different from other diuretics, as it only causes a slight increase in the amount of urine produced. Each of the active ingredients reduces blood pressure and they work together to control your blood pressure.

Blood pressure is the force pushing against the walls of the arteries as the heart pumps out the blood when it flows through the blood vessels. This pressure helps get your blood all around the body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have high blood pressure when your blood pressure stays higher than is needed, even when you are calm or relaxed.

There are usually no symptoms of high blood pressure. When blood pressure is high, damage can occur to the heart and blood vessels. The only way of knowing that you have high blood pressure is to have your blood pressure checked on a regular basis.

When Coversyl Plus should not be used

Do not take COVERSYL PLUS LD if:

  • you are hypersensitive (allergic) to perindopril or any other ACE inhibitor, or to indapamide or any other sulphonamides or any of the other ingredients of COVERSYL PLUS LD,

  • you have experienced symptoms such as wheezing, swelling of the face or tongue, intense itching or severe skin rashes with previous ACE inhibitor treatment or if you or a member of your family have had these symptoms in any other circumstances (a condition called angioedema),

  • you have trouble urinating.

COVERSYL PLUS LD is not intended for use in children and adolescents (under 18 years old).

What the medicinal ingredient are

The active substances of COVERSYL PLUS LD are perindopril erbumine and indapamide.

What the important nonmedicinal ingredients for Coversyl Plus are

The nonmedicinal ingredients in the tablet are: hydrophobic colloidal silica, lactose monohydrate, magnesium stearate and microcrystalline cellulose.

What dosage forms Coversyl Plus comes in

COVERSYL PLUS LD comes in tablets of 2 mg perindopril erbumine/0.625 mg indapamide.

Warnings and Precautions

Serious Warnings and Precautions

COVERSYL PLUS LD should not be used during pregnancy. If you discover that you are pregnant while taking COVERSYL PLUS LD, stop the medication and please contact your physician as soon as possible.

BEFORE you use COVERSYL PLUS LD talk to your doctor or pharmacist if

  • you have aortic stenosis (narrowing of the main blood vessel leading from the heart) or hypertrophic cardiomyopathy (cardiac muscle disease) or renal artery stenosis (narrowing of the artery supplying the kidney with blood),

  • you have any other heart problems or problems with your kidneys,

  • you have liver problems,

  • you are on haemodialysis,

  • you have a history of angioedema (swelling around your face, throat or tongue),

  • you suffer from a collagen disease such as systemic lupus erythematosus or scleroderma,

  • you have atherosclerosis (hardening of the arteries),

  • you suffer from hyperparathyroidism (dysfunctioning of the parathyroid gland),

  • you suffer from gout,

  • you have diabetes,

  • you are on a salt restricted diet or use salt substitutes which contain potassium,

  • you take lithium or potassium-sparing diuretics (spironolactone, triamterene) as their use with COVERSYL PLUS LD should be avoided (see “Interactions with This Medication:”)

  • you have recently suffered from excessive vomiting or diarrhoea.

If you have to undergo any dental or other surgery, inform the physician or dentist that you are taking COVERSYL PLUS LD.

Lactose is a non-medicinal ingredient in COVERSYL PLUS LD. Do not take COVERSYL PLUS LD if a doctor has told you that you have one of the following rare hereditary diseases:

Galactose intolerance

Lapp lactase deficiency

Glucose-galactose malabsorption.

Pregnancy and breast feeding

Taking COVERSYL PLUS LD during pregnancy can cause injury and even death to your foetus. This medicine should not be used during pregnancy. If you become pregnant or are planning to become pregnant while taking COVERSYL PLUS LD, stop the medication and report to your doctor as soon as possible. It is possible that COVERSYL PLUS LD passes into breast milk. You should not breast-feed while taking COVERSYL PLUS LD.

Interactions with Coversyl Plus

Drugs that may interact with COVERSYL PLUS LD, and that you should not be taking without the advice of your doctor, include

  • lithium (used to treat depression),

  • agents affecting sympathetic activity,

  • agents causing renin release,

  • diuretic therapy,

  • potassium-sparing diuretics (spironolactone, triamterene), potassium salts,

  • other medicines for treating high blood pressure,

  • digoxin (for the treatment of heart problems),

  • medicines to treat diabetes such as insulin or metformin,

  • gentamicin,

  • non-steroidal anti-inflammatory drugs (e.g. ibuprofen) or high dose salicylates (e.g. aspirin),

  • medicines to treat mental disorders such as depression, anxiety, schizophrenia (e.g. tricyclic antidepressants, neuroleptics).

Proper Use of Coversyl Plus

Usual dose (adult dosage)

Always follow your doctor's instructions about how to take COVERSYL PLUS LD. You should check with your doctor or pharmacist if you are not sure.

The recommended dose of COVERSYL PLUS LD to treat hypertension is one tablet taken in the morning. Your doctor may decide to increase the dose to 2 tablets daily or to modify the dosage regimen if you suffer from renal impairment.

Do not stop taking your medicine without the advice of your doctor even if you feel better. If you stop, serious complications of the disease may occur.

COVERSYL PLUS LD is for oral use. Tablets should be swallowed whole with a glass of water, preferably in the morning before a meal.

Your doctor will monitor your progress with COVERSYL PLUS LD and may perform occasional blood tests to ensure your continued health and safety.


If you suspect that you or someone else has taken more than the amount of COVERSYL PLUS LD prescribed by your doctor, contact your doctor or Regional Poison Control centre immediately.

Missed dose

Do not take a double dose to make up for forgotten doses. Just carry on with the next dose at the usual time.

Side Effects for Coversyl Plus and What to Do About Them

Like all medicines, COVERSYL PLUS LD can have side effects.

Most side effects are mild or moderate and usually transient. The most common side effects reported with COVERSYL PLUS LD are: stomach or abdominal pain, loss of appetite, nausea, constipation, cramps, taste disturbance, dry mouth and dry cough. Contact your doctor if these symptoms persist or get worse.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Common Dry mouth    
Dry cough    
Uncommon Feeling of tiredness    
Dizziness and/or fainting    
Mood swings    
Sleep disturbances    
Allergic reactions such as skin rashes    
Low blood pressure alone or upon standing up    
Swelling of the face, lips, throat, mouth or tongue which may cause difficulty breathing, speaking or swallowinga     • (Immediately)
Liver problem- symptoms of abdominal pain, nausea, vomiting, loss of appetite, jaundice (yellowing of eyes and skin, dark urine)    
Unusual heart beat (fast or irregular)    
a. This is known to occur more frequently in black patients.

This is not a complete list of side effects. For any unexpected effects while taking COVERSYL PLUS LD, contact your doctor or pharmacist.

Technical Information