Caduet Medication Information:

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Caduet 5mg/10mg
Caduet 5mg/20mg
Caduet 10mg/10mg
Caduet 10mg/20mg

About Caduet

What Caduet is used for

CADUET is a product that contains two active ingredients: amlodipine and atorvastatin and is to be used when your doctor deems it appropriate to use both medications.

Your doctor has prescribed CADUET to you to control your hypertension (high blood pressure) and/or to prevent angina attacks (chest pains) and to help lower your cholesterol or other fats in the blood (such as triglycerides). Even if you do not have high cholesterol, your doctor may still prescribe CADUET if you have high blood pressure and other risk factors in order to prevent your risk of cardiovascular disease such as heart attacks.

CADUET is just part of the treatment your doctor will plan with you to help keep you healthy. Depending on the condition of your health and your lifestyle, your doctor may recommend:

  • a change in your diet to control your weight, reduce your cholesterol, reduce intake of saturated fats and increase fiber

  • exercise that is right for you

  • quitting smoking or avoiding smoky places

  • giving up alcohol or drinking less

CADUET is not recommended in children.

What Caduet does

The amlodipine portion of CADUET belongs to a class of medications called calcium channel blockers. Calcium channel blockers, like amlodipine, block the transfer of calcium into the cells of the heart and blood vessels. This helps the blood vessels to relax, thereby lowering blood pressure and resulting in less work for the heart.

The atorvastatin portion of CADUET belongs to the class of medicines known as “statins”, more specifically called HMG-CoA reductase inhibitors. HMG-CoA reductase is an enzyme involved in regulating cholesterol levels in your body. Statins are used along with changes to exercise and diet to help control the amount of cholesterol produced by the body. High levels of cholesterol and other fats can cause heart disease by clogging the blood vessels that feed blood and oxygen to the heart.

Atorvastatin can help your body:

  • Decreases LDL (bad) cholesterol, triglyceride levels and other lipids/fats in the blood.

  • Increase HDL (good) cholesterol

  • Decrease the Total Cholesterol HDL-Cholesterol Ratio (TC: HDL-C Ratio). The ratio represents the balance between bad and good cholesterol.

Follow your doctor's instructions carefully.

When Caduet should not be used

Do not take CADUET if you:

  • are allergic to either amlodipine besylate and/or atorvastatin calcium or other medications known as dihydropyridines (for example, felodipine, and nifedipine) or any of the non-medicinal ingredients (see What the important nonmedicinal ingredients are:).

  • have been diagnosed with low blood pressure (less than 90 mmHg systolic).

  • have active liver disease or unexplained increases in liver enzymes.

  • are pregnant or breast-feeding.

What the medicinal ingredients for Caduet are

Amlodipine besylate and atorvastatin calcium.

What the important nonmedicinal ingredients for Caduet are

Other ingredients in CADUET tablets are: calcium carbonate, colloidal silicon dioxide (anhydrous), croscarmellose sodium, hydroxypropyl cellulose, magnesium stearate, microcrystalline cellulose and opadry II white 85F28751 or opadry II blue 85F10919, polysorbate 80, pregelatinized starch, and purified water.

What dosage forms Caduet comes in

CADUET tablets are available in 8 combinations of amlodipine/atorvastatin: 5 mg/10 mg, 5 mg/20 mg, 5 mg/40 mg, 5 mg/80 mg, 10 mg/10 mg, 10 mg/20 mg, 10 mg/40 mg, 10 mg/80 mg. CADUET tablets which contain 5 mg amlodipine will be film-coated white, and those with 10 mg amlodipine will be film-coated blue.

Warnings and Precautions

Serious Warnings and Precautions

Tell your doctor if you have any muscle pain, tenderness, soreness or weakness during treatment with CADUET.

Never change the dose of CADUET unless your doctor tells you to. Before you use CADUET talk to your doctor or pharmacist if you:

  • you have thyroid problems

  • you regularly drink three or more alcoholic drinks daily

  • you are taking any other cholesterol lowering medication such as fibrates (gemfibrozil, fenofibrate), niacin or ezetimibe

  • you are taking any other prescription, non-prescription or over-the-counter products especially those listed under Interactions with This Medication:

  • you have a family history of muscular disorders

  • you had any past problems with the muscles (pain, tenderness), after using an HMG-CoA reductase inhibitor (“statin”) such as atorvastatin (LIPITOR), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravacol), rosuvastatin (Crestor) or simvastatin (Zocor)

  • you have kidney or liver problems

  • you have diabetes (as the dosage of CADUET may need to be adjusted)

  • you have undergone surgery or other tissue injury

  • you do excessive physical exercise

  • you have severe hypotension (low blood pressure)

  • you have taken any of the following medicines before, and you had an allergic reaction:

    amlodipine or other derivatives:

    • nifedipine (e.g. ADALAT XL)

    • felodipine (e.g. PLENDIL, RENEDIL)

    atorvastatin (atorvastatin) or other derivatives:

    • simvastatin (e.g. ZOCOR)

    • lovastatin (e.g. MEVACOR)

    • pravastatin (e.g. PRAVACHOL)

    • fluvastatin (e.g. LESCOL)

    • rosuvastatin (e.g. CRESTOR)


  • Before using this medication, discuss the following with your doctor:

    • if you are breast-feeding your baby, you should not take CADUET. This medicine may be present in your breast milk.

    • Cholesterol compounds are essential elements for the development of a fetus. Cholesterol-lowering drugs can harm the fetus. If you are of child-bearing age, discuss with your doctor the potential hazards to the fetus and the importance of birth control methods.

    • This medicine should not be used by pregnant women. If you become pregnant, discontinue use immediately and discuss with your doctor.

Interactions with Caduet

Drugs that may interact with CADUET include:

  • corticosteroids (cortisone-like medicines)

  • cyclosporine (e.g. SANDIMMUNE, NEORAL)

  • gemfibrozil (LOPID)

  • fenofibrate (e.g. LIPIDIL MICRO)

  • bezafibrate (e.g. BEZALIP)

  • lipid-lowering doses of niacin (nicotinic acid)

  • spironolactone

  • cimetidine

  • erythromycin, clarithromycin or azole antifungal agents (ketoconazole or itraconazole)

  • nefazodone (e.g. SERZONE)

  • indinavir sulfate (e.g. CRIXIVAN), nelfinavir mesylate (e.g. VIRACEPT), ritonavir (e.g. NORVIR), saquinavir mesylate (INVIRASE)

  • digoxin

  • diltiazem

  • efavirenz, rifampin

  • sildenafil (VIAGRA) may lower your blood pressure

  • beta-blockers (medicines used to lower your blood pressure)

  • antacids (frequent use) and CADUET should be taken 2 hours apart

  • grapefruit juice—especially if ingesting upwards of 1.2 litres of grapefruit juice at once

Certain non-prescription drugs may be harmful to you or may interfere with CADUET. Swallow CADUET with water.

Proper Use of Caduet

Usual Dose

The dose range for CADUET is 5/10 to 10/80 mg once daily. The maximum dose of CADUET is 10/80 mg once daily. CADUET is available in a broad dose-range. Your doctor will decide on the best dose for you. Your individual health and tolerance to medications will help your doctor decide how much of each ingredient will be best for you.

Follow your doctor's dosing instructions carefully. Take your CADUET as a single dose once a day. Never change the dose unless your doctor tells you to. It does not matter if you take CADUET with food or without food. Ideally, so you won't forget, you should get in the habit of taking your medicine at the same time every day. Follow the plan that you and your doctor make for diet, exercise, weight control and smoking cessation.

We often cannot see or feel the problems that high cholesterol and high blood pressure cause until a lot of time has passed or until a major event like a heart attack occurs. You and your doctor will be following your cholesterol and blood pressure levels to bring them down and keep them in a safe range. Here are some important tips to consider:

  • Report to all follow-up visits scheduled by your doctor. This is important to follow through with all lab tests requested by your doctor. These tests will help to follow/track your health in general, for example, your kidneys, liver and blood sugar levels.

  • It is important to take all of your medication and to refill your prescription on time so as not to miss any doses.

  • Don't drink too much alcohol while you are taking CADUET. Talk to your doctor about how much is too much for you.

  • If you get sick, have an operation, or need medical treatment while you are taking CADUET, inform your doctor or pharmacist that you are taking CADUET.

  • If you have to take any other medicine—prescription, non-prescription or over-the-counter—while you are taking CADUET, talk to your doctor or pharmacist first.

  • If you have to see a different doctor for any reason, be sure to inform him/her that you are taking CADUET.


In case of an accidental overdose, call your doctor right away or go to the nearest emergency room clinic, or call your nearest poison control center immediately.

Missed dose

If you miss taking your medicine, take it as soon as you can. But if it is almost time for your next dose, skip the missed dose and just take the next dose. Don't take a double dose.

Side Effects for Caduet and What to Do About Them

Along with its intended action, any medication may cause unwanted effects. CADUET is generally well tolerated. However, check with your doctor or pharmacist promptly if any of the following persist or become troublesome:

  • stomach pain or upset, vomiting or throwing up

  • gas, constipation, diarrhea

  • headache

  • skin rash

  • insomnia (difficulty sleeping), drowsiness, fatigue

Very rarely, a few people may suffer from jaundice, from a liver condition called hepatitis.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Common Swelling of the ankles    
Rare Muscle pain that you cannot explain    
Muscle tenderness or weakness    
Generalized weakness, especially if you don’t feel well    
Brownish or discoloured urine    
Increased frequency, severity, duration of angina (chest pains)    
Low blood pressure: (dizziness, or dizziness when rising from sitting or laying down)    
Change in rhythm or pace of heart beats    
Numbness or tingling in hands/fingers    
Shortness of breath    
Abnormal vision    

This is not a complete list of side effects. If you notice anything unusual or any unexpected effects while taking CADUET, contact your doctor or pharmacist.

Caduet Facts

Caduet is formulated to reduce high blood pressure and elevated cholesterol in a pill that combines two medications, NORVASC and LIPITOR.

Caduet is manufactured by Pfizer Ireland Pharmaceuticals in Dublin and distributed by Pfizer Labs, headquartered in New York.

Caduet was first marketed in the U.S. in January 2004.

Caduet reduces the risk of heart attack and stroke in patients who have no history of cardiac disease.


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