Avalide Medication Information:

Price Break On Avalide
Generic is available for less money: Generic Irbesartan/HCTZ

Avalide medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Avalide 150mg/12.5mg
Avalide 300mg/12.5mg

Avalide General Information:

Avalide (generic name: irbesartan hydrocholorothiazide) is a combination of an angiotensin II receptor antagonist (irbesartan) which keeps blood vessels from narrowing, and a thiazide diuretic (hydrochlorothiazide) which reduces fluid retention caused by too much salt in the body.

How Does Avalide Work?

Avalide is used in the treatment of hypertension (high blood pressure), and may be especially effective in patients who do not respond to single ingredient high blood pressure medication, or for those patients who are more likely to need multiple drugs in order to control their blood pressure.

When/How is Avalide taken/used/applied?

Avalide is taken orally, once a day or as directed by your doctor. Avalide may be taken with or without food, and can be taken with other similar medications. Increased fluid intake is recommended in order to avoid dehydration, although to avoid frequent nighttime urination you may wish to take Avalide no later than early evening. Patients should continue taking Avalide even if they feel well. If you miss a dose, take it as close to your regularly scheduled time as possible. Do not take 2 doses at once.

Side Effects of Avalide:

Side effects are generally mild, and have been shown to occur in less than 1% of study participants. These side effects may include drowsiness, dizziness or lightheadedness, chest pain, fatigue, flu-like symptoms, swelling, rapid heartbeat, abdominal pain, heartburn, nausea or vomiting, allergic reaction, musculoskeletal pain, dizziness, and abnormal urination. The most common side effects include headache, sinus problems, cough, sore throat, diarrhea, runny nose, urinary tract infection, rash, anxiety/nervousness, and muscle cramps. The percentage of common side effects is similar to those participants taking a placebo. Very rare cases of hives, welts, hepatitis, and hyperkalemia (abnormally high levels of potassium) have been documented. Avalide may cause increased sensitivity to natural and artificial sunlight.

Other Brand Names for Avalide:

None. At this time there are no other brand names for Avalide.

Safety Information:

Do not drive or perform other tasks that require specific attention until you know how your body will react to Avalide. If you are taking antidiabetic drugs (orally or via injection) you may need to adjust your dosage after taking Avalide. Taking Avalide may increase your responsiveness to certain types of anesthesia. Non-steroidal anti-inflammatory drugs (NSAIDS) such as aspirin, ibuprofen and naproxen, may reduce the effectiveness of Avalide. Before using Avalide, tell your doctor if you have any of the following: kidney disease, liver disease, congestive heart failure, altered levels (low or high) of potassium in your bloodstream, asthma, high cholesterol, elevated triglyceride levels, gout, lupus, diabetes, or an allergy to sulfa drugs. Avalide is not recommended for those with reduced kidney or liver function. You should not take Avalide if you are taking lithium, due the diuretic portion of the drug and the increased risk of lithium toxicity. Avalide can cause fetal harm to pregnant women. Nursing mothers should consult with their doctors before taking Avalide.


Avalide comes in multiple dosages, including 150/12.5 mg, 300/12.5 mg, and 300/25 mg.

Visual Description:

150/12.5 mg and 300/12.5 mg Avalide tablets are peach in color, oval with a heart impression on one side, and either 2775 on the opposite side (for the 150/12.5 mg dose) or 2776 (for the 300/12.5 mg dose). The 300/25 mg dose is dark pink in color, with a heart impression on one side and 2788 on the opposite side.

About Avalide

What Avalide is used for

AVALIDE is used to treat hypertension (high blood pressure).

What Avalide does

The irbesartan ingredient of AVALIDE lowers blood pressure by specifically blocking a naturally occurring substance called angiotensin II, which normally narrows your blood vessels. The irbesartan ingredient of AVALIDE allows the blood vessels to relax. The hydrochlorothiazide ingredient of AVALIDE works by making your kidneys pass more water and salt. Together irbesartan and hydrochlorothiazide lower high blood pressure. Although your doctor will be able to tell you that the medicine is working by measuring your blood pressure, you will probably feel no different while you are taking AVALIDE.

If your blood pressure remains too high after an adequate trial period, your doctor may decide to increase the dose of either irbesartan or hydrochlorothiazide.

When Avalide should not be used

Do not take AVALIDE:

  • If you are allergic to any of its ingredients or to sulfonamide (see What the nonmedicinal ingredients are:)

  • If you have difficulty in producing urine

If you are not sure whether you should start taking AVALIDE, contact your doctor or your pharmacist.

  • Pregnancy and Breast-feeding: It is not recommended that you use AVALIDE while you are pregnant or breast-feeding. If you are pregnant or planning to become pregnant while taking AVALIDE, talk to your doctor as soon as possible.


AVALIDE should not be given to children.

What the medicinal ingredients for Avalide are

Each tablet of AVALIDE contains irbesartan and hydrochlorothiazide.

What the nonmedicinal ingredients for Avalide are

AVALIDE 150/12.5 mg tablets contain the following nonmedicinal ingredients: croscarmellose sodium, ferric oxide red and ferric oxide yellow. lactose, magnesium stearate, microcrystalline cellulose, pregelatinized starch, silicon dioxide.

AVALIDE 300/12.5 mg tablets contain the following nonmedicinal ingredients: croscarmellose sodium, ferric oxide red and ferric oxide yellow. lactose, magnesium stearate, microcrystalline cellulose, pregelatinized starch, silicon dioxide.

The 300/25 mg strength contains black iron oxides, carnauba wax, croscarmellose sodium, ferric oxide red, and ferric oxide yellow, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, pregelatinized starch, silicon dioxide, titanium dioxide.

What dosage forms Avalide comes in

AVALIDE tablets are available in three different strengths. Tablets which contain 150 mg of irbesartan and 12.5 mg of hydrochlorothiazide come in the form of peach coloured, oval, biconvex tablets with a heart shape stamped on one side and the digits 2775 on the other side.

The next strength contains 300 mg of irbesartan and 12.5 mg of hydrochlorothiazide. These come in a similar form and colour, with a heart shape stamped on one side and the digits 2776 on the other side.

The highest strength tablets contain 300 mg of irbesartan and 25 mg of hydrochlorothiazide. These tablets come in the form of pink coloured, film-coated, biconvex, oval tablets, with a heart shape stamped on one side and the digits 2788 on the other.

Warnings and Precautions

Serious Warnings and Precautions

AVALIDE should not to be used during pregnancy. If you discover that you are pregnant while taking AVALIDE stop the medication and please contact your physician.

BEFORE you use AVALIDE, talk to your doctor or pharmacist about any medical problems you have or have had, and about any allergies. Tell your doctor if you have recently suffered from excess vomiting or diarrhea.

  • It is particularly important to tell your doctor if you have liver or kidney disease, gout, diabetes, lupus erythematosus, or if you are being treated with other diuretics (water pills). In these cases, your doctor may need to adjust the dose of your medications.

  • Before surgery and general anesthesia (even at the dentist's office), tell the doctor or dentist that you are taking AVALIDE, as there may be a sudden fall in blood pressure associated with general anesthesia.

  • You are pregnant, breast-feeding or thinking of becoming pregnant? Taking AVALIDE during pregnancy can cause injury and even death to your baby. This medication should not be used during pregnancy. If you are planning to become pregnant while taking AVALIDE, contact immediately your doctor.

It is possible that AVALIDE passes into breast milk. You should discuss with your doctor about taking AVALIDE while breast-feeding.

Wait until you know how you respond to your medication before performing tasks that require special attention (for example, driving an automobile or operating dangerous machinery).

Interactions with Avalide

You should have informed your doctor of any medicines you are taking. These include medicines obtained without prescription.

The diuretic agent, hydrochlorothiazide, contained in AVALIDE may interact with other medicines.

Preparations containing lithium should not be taken with AVALIDE without close supervision by your doctor.

Special precautionary measures (e.g., blood tests) may be appropriate if you take potassium supplements, potassium-containing salt substitutes or potassium sparing medicines, other diuretics (water pills), warfarin, digoxin, antidiabetic drugs, alcohol, barbiturates, narcotics, pressor amines, skeletal muscle relaxants, cholestyramine and colestipol resins.

If calcium or a calcium sparing drug (e.g., vitamin D therapy) is prescribed, serum calcium levels should be monitored and calcium dosage adjusted accordingly.

It is important for your doctor to know if you are taking other medicines to reduce your blood pressure, or if you are taking steroids, or anti-inflammatory medicines used in arthritis.

Proper Use of Avalide

Usual dose

Take AVALIDE every day exactly as your doctor has instructed.

It is important to continue taking AVALIDE for as long as your doctor prescribes it in order to maintain control of your blood pressure.

AVALIDE may be taken with or without food, however it should be taken consistently with respect to food intake.


For management of a suspected drug overdose, or in case of an actual overdose, contact your Regional Poison Centre or your doctor immediately, so that medical attention may be given promptly.

Missed dose

Try to take AVALIDE daily as prescribed. However, if you miss a dose, do not take an extra dose. Just resume your normal schedule.

Side Effects for Avalide and What to Do About Them

Along with its intended action, any medication, including AVALIDE, may cause side effects. In most patients, AVALIDE is well tolerated. Side effects may include:

  • Headache

  • Dizziness

  • Fatigue

  • Muscle pain

Side effects such as myalgia (muscle pain), myasthenia (muscle weakness), myositis (muscle inflammation) and rhabdomyolysis (a muscle wasting disease), in rare cases leading to kidney failure, have been reported with the use of angiotensin II receptor blockers, the class of drugs to which a component of AVALIDE belongs. You should contact your physician promptly if you experience muscle pain that you cannot explain, muscle tenderness or weakness, generalised weakness, or when you notice dark/brown urine.

Your physician or pharmacist has a more complete list. Tell your physician or pharmacist promptly about these or any other unusual symptoms.

Serious Side Effects, How Often They Happen and What to Do About Them
Symptom/Effect Talk with your doctor or pharmacist Stop taking drug and call your doctor or pharmacist
Only if severe In all cases
Uncommon low blood pressure associated with dizziness/lightheadedness, (hypotension)    
fainting (syncope)  
muscle pain you cannot explain    
muscle tenderness or weakness    
generalized weakness    
dark/brown urine    

This is not a complete list of side effects. If you have any unexpected effects while taking AVALIDE, contact your doctor or pharmacist.

Avalide Facts

The drug Avalide is manufactured and distributed by Bristol-Myers Squibb.

Six clinical trials of Avalide evaluated safety of the drug.

A total of 1,694 patients with essential hypertension participated in the clinical trials of Avalide.

Avalide obtained original or tentative approval from the FDA on September 30, 1997.


Technical Information

What Others Are Saying About avalide:

Tarah A. Fleetwood on Tuesday April 21, 2009

I've taken several different prescription medications over the years, and I'm glad to have found your website because if there's one thing I like doing, it's saving money. However, I won't do that at the expense of professionalism, which is one thing you've got going for you. I just placed a refill order for Avalide and I thought I'd drop a note to say 'thanks'.