Altace

Altace Medication Information:

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Generic is available for less money: Generic Ramipril

Altace medication comes in several different strengths; click on the strength you need to view prices from pharmacies competing to earn your business.

Altace 1.2 mg
Altace 2.5 mg
Altace 5 mg
Altace 10 mg

Altace General Information

ALTACE is an ACE (angiotensin-converting enzyme) inhibitor medication that blocks the conversion of angiotensin I into angiotension II. Angiotension II constricts the blood vessels.

How does Altace work?

Altace inhibits the synthesis of angiotension II, a potent vasoconstrictor that acts to narrow the blood vessels, which makes the heart pump harder to circulate blood throughout the body. As the heart works harder to circulate blood through narrow blood vessels, the blood pressure increases resulting in hypertension. This medication works by dilating constricted blood vessels, which results in lowering the blood pressure, thus enabling the heart to be a more efficient pump.

The anti conversion properties of Altace helps in reducing elevated blood pressure readings. It can be used as a stand alone medication or in conjunction with thiazide diruetics in the treatment of high blood pressure. It is also used to treat heart failure in patients who have been stablized in the initial days following a heart attack. Additionally, Altace can be administered as a preventative measure to reduce the risk of heart attack, stroke, and death from cardiovascular disease in individuals at high risk for the development of coronary artery disease, or CAD.

When/How is Altace taken/used/applied?

Altace is taken by mouth with food or without food at the same time each day. An initial dose of 2.5 mg is administered and adjusted according to how the blood pressure responds. The normal dose is 20 mg per day and can be taken as a single dose or divided up into two doses of 10 mg twice per day. For patients with swallowing difficulties, a capsule can be opened and sprinkled into applesauce or water and mixed in. The mixture maintains stability at room temperature for twenty-four hours or forty-eight hours in refrigeration. Diuretics should be discontinued three days prior to beginning this medication.

Side Effects of Altace

Adverse reactions can affect the cardiovascular system with symptoms of tachycardia (rapid heart rate), angina pectoris, heart failure, heart attack, and hypotension. Dermatological reactions include rash, pruritus, photosensitivity, erythema multiforme, and Stevens-Johnson syndrome. Gastrointestinal tract side effects can include gastric irritation, aphthous ulcers (canker sores), dysgeusia (decreased sense of taste), cholestatic jaundice, hepatocellular injury, anorexia, constipation, and pancreatitis. In the genitourinary system, Altace can cause proteinuria (protein in the urine), renal insufficiency, kidney failure, polyuria (large volume of urine), oliguria (small urine volume), and frequent urination. Hematologic reactions can manifest as neutropenia, agranulocytosis, thrombocytopenia (reduced blood platelets), and hemolytic anemia. Other known side effects of Altace are coughing, generalized discomfort, dry mouth, and angioedema.

Other Brand Names for Altace:

Altace also goes by the generic name of ramipril. Also known by the following brand names of Acovil; Altace; Carasel; Cardace; Delix; Hytren; Lostapres; Pramace; Quark; Ramace; Triatec; Tritace; Unipril; Vesdil

Safety Information:

This medication crosses the placenta and can cause harm to the unborn fetus, and should not be taken by women who are pregnant or who plan to be pregnant. Altace can enter breast milk and cause damage to a nursing child. If pregnancy occurs while taking this drug, discontinue usage and notify your health care provider immediately.

Do not drink alcoholic beverages as this may compound the antihypertensive actions of this medication and cause symptoms of reaction to increase. Avoid the use of salt substitutes or potassium supplements during therapy, unless your health care provider has advised you to do so.

Avoid dehydration as this can cause a very low drop in blood pressure, electrolyte imbalance, and renal failure. Dehydration can be caused by vomiting, frequent loose stools, and profuse perspiration. Drink plenty of fluids to prevent these complications.

Do not take this medication if you are allergic to ramipril or other ACE inhibitors, which include benazepril, captopril, fosinopril, enalapril, lisinopril, moexipril, perindopril, quinapril, or trandolapril.

Precautionary measures are advised in the presence of certain health conditions such as diseases of the kidneys, liver, and heart, as well as persons diagnosed with diabetes mellitis. In addition, illnesses related to the connective tissues such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, and rheumatoid arthritis indicate caution when taking this drug.

Dosage

Altace is available as a capsule or tablet in the following dosages:

Capsules:

  • 1.25 mg
  • 2.5 mg
  • 5 mg
  • 10 mg

Tablets:

  • 1.25 mg
  • 2.5 mg
  • 5 mg
  • 10 mg

Visual Description:

All capsules have Altace and the dosage amount imprinted with black lettering.

  • 1.25 mg pale green capsule imprinted with AL1.25
  • 2.5 mg orange capsule imprinted with AL2.5
  • 5 mg red capsule imprinted with AL5
  • 10 mg blue capsule imprinted with AL10

Tablets:

  • 1.25 mg White, oval tablet imprinted with AL1.25
  • 2.5 mg orange, oval tablet imprinted with AL2.5
  • 5 mg red, oval tablet imprinted with AL5
  • 10 mg blue, oval tablet imprinted with AL10

About Altace

What Altace is used for:

For Patients with High Blood Pressure

Your doctor has prescribed ALTACE, a medication that helps to control high blood pressure.

For Patients Following a Recent Heart Attack

Your doctor has prescribed ALTACE to reduce the effort required by your heart to pump blood. This is to compensate for the reduced pumping power that may have resulted from your heart attack. ALTACE has been shown to improve survival and reduce hospitalizations for heart failure in patients that are now clinically stable and recovering from recent heart attacks.

For the Management of Patients at Increased Risk of Cardiovascular Events:

Your doctor has prescribed ALTACE because:

  • You have coronary heart disease (such as chest pains or angina, or have had a heart attack in the past)

  • You had a stroke

  • You have peripheral vascular disease (poor blood circulation)

  • You have diabetes and at least one of the following physical conditions: high blood pressure, elevated total cholesterol levels, low high-density lipoprotein (HDL) levels, cigarette smoking or documented tiny amounts of albumin from your blood detected in your urine (microalbuminuria).

ALTACE may lower the risk of heart attack, stroke, or death from heart disease in some patients who have a heart problem or poor blood circulation. Take your medication as instructed by your Doctor.

Managing Your Lifestyle:

Keeping your blood pressure controlled

It takes more than just medication to reduce blood pressure. Discuss the risk factors, and how they apply to your lifestyle, with your doctor. You may have to modify some of your daily habits to keep your blood pressure down.

Exercise regularly. It will help to keep your weight down, make you feel more energetic and is a good way to deal with stress. If you are not exercising regularly, be sure to discuss a fitness plan with your doctor.

Remember, hypertension is a long-term disease without symptoms. Just because you feel fine does not mean you can stop taking your medication. If you stop, serious complications of the disease may occur. Therefore, you should continue to take ALTACE regularly, as prescribed by your doctor.

The “lifestyle” part of your treatment is as important as your medication. By working as a team with your doctor, you can help reduce the risk of complications to maintain the style of life you are accustomed to.

  • Alcohol: Avoid alcoholic beverages until you have discussed their use with your doctor. Alcohol consumption may alter your blood pressure and/or increase the possibility of dizziness or fainting.

  • Diet: Generally, avoid fatty foods and food that is high in salt or cholesterol.

  • Smoking: Avoid it completely.

What Altace does:

ALTACE opens blood vessels to reduce blood pressure, just like the way opening a hose reduces water pressure. It is not, however, a cure.

When Altace should not be used

If:

  • You have had an allergic reaction to ramipril and/or any components of ALTACE capsules (see What the nonmedicinal ingredients are:) or to any other medication of the same group of medicines called ACE (angiotensin converting enzyme) inhibitors (see Warning and Precautions:).

  • You have a history of a condition called angioedema (dysfiguring type of temporary swelling which can be hazardous) (see Side Effects and What to Do About Them:).

  • You are pregnant or breast-feeding.

  • You have narrowing of the arteries to one or both kidneys (renal artery stenosis).

  • You have hypotension (low blood pressure).

What the medicinal ingredient is

ALTACE contains ramipril.

What the nonmedicinal ingredients for Altace are

Pre-gelatinized maize starch and hard gelatin capsules (which are composed of: titanium dioxide, and/or yellow iron oxide, and/or black iron oxide, and/or FD&C Red No. 3, and/or D&C Red No. 28 and/or FD&C Blue No. 1, and/or FD&C Blue No. 2).

What dosage forms Altace comes in

Capsules 1.25 mg, 2.5 mg, 5 mg, 10 mg and 15 mg.


Warning and Precautions

Serious Warning and Precautions

ALTACE should not be used during pregnancy. If you discover that you are pregnant while taking ALTACE, stop the medication and please contact your physician as soon as possible.

BEFORE you use ALTACE talk to your doctor or pharmacist if:

You are currently taking any other medications, whether on prescription or otherwise (see Interactions with This Medication:)?

You should not be taking salt substitutes, potassium supplements or potassium containing medicine without the advice of your doctor. If you have to undergo any dental or other surgery, inform the dentist or physician in charge that you are taking this medicine.

You suffer from any other condition?

The presence of other medical problems may affect the use of ALTACE. If you have developed heart failure after a heart attack, you may have to limit your physical activities: before you begin exercising, be sure to consult with your doctor. Make sure you tell your doctor if you have any other medical problems, especially if you have diabetes, heart or blood vessel disease.

If you have liver problems or disease, you may have a different response to ALTACE. Your doctor should take blood tests to measure your liver function before you start taking ALTACE and occasionally throughout your treatment.

If you have kidney problems or disease, your doctor should take regular blood tests to measure your kidney function and the levels of potassium in your blood.

Raynaud's phenomenon is a condition resulting from poor circulation in the extremities (i.e., fingers and toes). It may begin or get worse.

Your doctor may order regular blood tests or blood pressure checks, to monitor your health while on ALTACE especially if you take other medications, like diuretics (water pills) (see Interactions with This Medication:).

You are pregnant, breast-feeding or thinking of becoming pregnant?

Taking ALTACE during pregnancy can cause injury and even death to your baby. This medicine should not be used during pregnancy. If you become pregnant while taking ALTACE, stop the medication and report promptly to your doctor as soon as possible. It is possible that ALTACE passes into breast milk. You should not breast-feed while taking ALTACE.

Remember

Use this drug as directed by your doctor. All drugs can have both helpful and harmful effects. Both depend on the person and his or her condition. This leaflet alerts you to some of the times you should call your doctor. Other situations, which cannot be predicted, can arise. Nothing in this leaflet should stop you from calling your doctor or pharmacist with any questions or concerns you have about ALTACE.


Interactions with Altace

Some drugs may have a negative effect on ALTACE or ALTACE may have a negative effect on other drugs. If you are currently taking any other medications, whether on prescription or otherwise, inform your doctor or pharmacist. This is especially important if you are taking diuretics (water pills) or any other medication to reduce blood pressure which may add to the blood pressure lowering effect of ALTACE.

Drugs that may interact with ALTACE include agents that increase potassium in the blood such as potassium supplements, salt substitutes or medicines which contain potassium. These should be used with caution.

Other drugs that may affect the efficacy of ALTACE include: nitrates, ASA (aspirin), heparin, allopurinol, immunosuppressants, corticosteroids, procainamide, cytostatics and other substances that may change the normal results expected to be measured on a routine blood test.


Proper Use of Altace

Usual dose

It is important to take ALTACE at the same time every day as prescribed by your doctor.

High Blood Pressure:

The recommended initial dosage of ALTACE is 2.5 mg once daily. Your doctor will determine the appropriate dosage.

Altace Facts

The original or tentative approval of ALTACE by the FDA occurred on January 28, 1991.

Foreign controlled trials of ALTACE evaluated safety in 1,107 patients.

More than 4,000 patients participated in the U.S. controlled trials of ALTACE.

Distributed by King Pharmaceuticals, ALTACE is manufactured by Arrow Pharm (Malta) Ltd.

 

Technical Information

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