Retrovir 100 mg

 
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Best Value On Brand Retrovir 100 mg
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Retrovir 100 mg Prescription Required
100 capsules for $151.11 ($1.51 per capsule)
Retrovir from online pharmacy: South Africa
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About Retrovir

What Retrovir is used for

The name of your medicine is RETROVIR (AZT). RETROVIR (AZT) can only be obtained with a prescription from your doctor. RETROVIR (AZT) is an antiretroviral medication. It is used together with other antiviral medicines to delay the progression of HIV infection.

RETROVIR (AZT) is prescribed to slow down the effects of HIV virus; it is not a cure. RETROVIR (AZT) is also used for the prevention of maternal-fetal HIV transmission.

What Retrovir does:

The human immunodeficiency virus (HIV) is a retrovirus. Infection with HIV damages the immune system and can lead to Acquired Immune Deficiency Syndrome (AIDS) and other related illnesses.

RETROVIR (AZT) is an antiretroviral medication. It is used together with other antiviral medicines to delay the progression of HIV infection. RETROVIR (AZT) does not cure AIDS or kill the HIV virus, but helps to prevent further damage to the immune system by slowing down the production of new viruses.

When Retrovir should not be used:

RETROVIR (AZT) should not be used in patients:

  • who have potentially life-threatening allergic reactions to any component of the formulations (see What the important nonmedicinal ingredients are:).

  • with low blood cell counts anemia or low hemoglobin levels (blood component which carries oxygen in the blood).

What the medicinal ingredient is:

RETROVIR (AZT) contains zidovudine.

What the important nonmedicinal ingredients for Retrovir are

Capsules

Each RETROVIR (AZT) 100 mg Capsule contains 100 mg of zidovudine and the non- medicinal ingredients corn starch, microcrystalline cellulose, sodium starch glycolate and magnesium stearate. The capsule imprinted with edible black ink, is made of gelatine.

Syrup

Each teaspoonful (5 mL) of RETROVIR (AZT) Syrup contains 50 mg of zidovudine and the nonmedicinal ingredients sucrose, glycerine, strawberry flavour, citric acid and candied sugar flavour. Sodium benzoate (0.2%) is added as a preservative and sodium hydroxide may have been added to adjust pH.

Injection

Each mL of RETROVIR (AZT) Injection contains 10 mg of zidovudine in Water for Injection. Hydrochloric acid or sodium hydroxide may have been added to adjust the pH to approximately 5.5. RETROVIR (AZT) for Injection contains no preservatives.

What dosage forms Retrovir comes in

RETROVIR (AZT) is available as zidovudine capsules USP (100 mg/capsule), zidovudine syrup (50 mg/5 mL), and zidovudine for injection (10 mg/mL) (20 mL single use vial).


Warnings and Precautions

BEFORE you use RETROVIR (AZT) talk to your doctor or pharmacist if:

  • you are allergic to any ingredient in this medicine.

  • you have bone marrow problems (low blood cell counts).

  • you have hepatomegaly (enlarged liver), hepatitis (inflamed liver) or other known risk factors for liver disease.

  • you have kidney disease.

  • you are taking other drugs (see Interactions with This Medication:).

  • you are pregnant or breastfeeding.

  • your baby or infant was exposed to Nucleoside Reverse Transcriptase Inhibitors (NRTIs) during pregnancy or labour.

  • you are taking ribavarin as it could cause or worsen anemia (symptoms of tiredness, shortness of breath).

    Your doctor will advise whether you should stop taking RETROVIR (AZT).

Illness associated with HIV infection, including other infections, may still happen. Therefore, it is very important to keep appointments with your doctor and to report any change in your health as it occurs.

RETROVIR (AZT) has been extensively studied in humans for limited periods of time. Studies have shown that treatment will benefit your health. However, the effectiveness and overall safety of RETROVIR (AZT) is unknown beyond the length of time for which it has been studied.

The effectiveness and overall safety RETROVIR (AZT) in women, intravenous drug users, and ethnic minorities are not different than that observed in white males.

Use of Retrovir During Pregnancy and Breast Feeding

For pregnant women who are considering the use of RETROVIR (AZT) during pregnancy for the prevention of HIV-transmission to their infants, it is important to understand that transmission may still occur in some cases (about 8%) despite using RETROVIR (AZT). The long-term safety in treated fetuses, neonates, or infants has not been established.

Babies and infants exposed to Nucleoside Reverse Transcriptase Inhibitors (NRTIs) during pregnancy or labour, show minor temporary increases in blood levels of lactate. The clinical importance of these temporary increases is unknown.

There have been very rare reports of diseases that affect the nervous system such as delayed development and seizures.

These findings do not affect current recommendations to use antiretroviral therapy in pregnant women to prevent transmission of HIV to their babies.

HIV-infected women should not breast-feed in order to prevent transmission of HIV to a child who may not yet be infected.


Interactions with Retrovir

Some drugs may change the usefulness and safety of RETROVIR (AZT). It is therefore very important that you tell your doctor before you decide to take any new drugs, even if these are available without a prescription.

Drugs that may interact with RETROVIR (AZT) include: atovaquone, bone marrow suppressive agents/cytotoxic agents, clarithromycin, fluconazole, ganciclovir, interferon-alpha, lamivudine, methadone, phenytoin, probenecid, stavudine, valproic acid, and others such as trimethoprim-sulfamethoxazole, pyrimethamine, acyclovir and rifampin.

For patients receiving combination therapy with RETROVIR (AZT) and zalcitabine, it is important to understand that the major toxicity of zalcitabine is peripheral neuropathy. Pancreatitis is another serious and potentially life-threatening toxicity that has been reported in less than 1% of patients treated with zalcitabine alone. Symptoms of peripheral neuropathy include tingling, burning, pain, or numbness in the hands or feet. Symptoms of pancreatitis include abdominal pain, nausea and vomiting. These symptoms should be promptly reported to your physician. Since the development of peripheral neuropathy seems to be dose-related to zalcitabine, you should follow your physician’s instructions regarding the prescribed dose. The long-term effects of zalcitabine in combination with RETROVIR (AZT) are presently unknown. If you are a female of child-bearing age, you should use effective contraception while using zalcitabine.

An additional precaution is that some other drugs may change the usefulness and safety of RETROVIR (AZT).


Proper Use of Retrovir

Usual dose

You should be counselled about the use of RETROVIR (AZT).

It is important to take RETROVIR (AZT) exactly as prescribed. Altering the dose without the direct advice of your physician is unwise, as is sharing your medication with others.

Oral Administration

Adults

The recommended total oral daily dose of RETROVIR (AZT) is 600 mg per day in divided doses in combination with other antiretroviral agents. Suggested Dosing Regimens:

  • Capsules: three 100 mg RETROVIR (AZT) capsules every 12 hours; OR two 100 mg RETROVIR (AZT) capsules every 8 hours.

  • Syrup: 6 teaspoonfuls (30 mL) RETROVIR (AZT) syrup every 12 hours; OR 4 teaspoonfuls (20 mL) RETROVIR (AZT) syrup every 8 hours.

Children

The recommended oral dose in children 3 months to 12 years of age is 180 mg/m2 every 6 hours (720 mg/m2 per day). Do not exceed 200 mg for any individual dose.

Injection

Technical Information